Sclerostin and IL-1Ra in Rheumatoid Iraqi Patients after Biological Therapy

Abdalwahab, S.; Kadhim, Haider Sabah; Alqasim, Alauldeen Mudhafar Zubair; Gorial, Faiq I.

doi:10.20546/ijcmas.2016.509.082

Cited by 2 publications

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“…Afterwards, β-catenin is a an intracellular signal transducer that activate target genes which promote osteoblast differentiation (18,19). Sclerostin (SOST) is a glycoprotein and a product of the SOST gene located on chromosome 17q12-q21 (20,21). It is not only secreted from osteocytes, but also by other cells such as chondrocytes, cementocytes as well as from the kidney and liver (17,20).…”

Section: Introductionmentioning

confidence: 99%

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The role of sclerostin in rheumatoid arthritis in a Syrian population: a potential indicator of disease activity in newly-diagnosed patients

Hussein

Kakaje

Aboukhais

2022

Preprint

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Background: Rheumatoid arthritis (RA) is an autoimmune disease that can cause irreversible joint deformities and bone erosions. Criteria to diagnose RA includs many laboratory tests with variable sensitivity and specificity. Sclerostin, a Wnt inhibitor, could be associated with the reduced bone formation in RA. This study aims to measure sclerostin level and its association with RA and its activity.Materials and methods: This study contained fifty-eight RA cases and thirty controls who were age and sex matched. All laboratory tests were conducted on both groups, including sclerostin which was measured by enzyme-linked immunosorbent assay (ELISA). The disease activity was assessed using disease activity scores (DAS28).Results: Our results showed that sclerostin levels were significantly higher in RA patients compared to control (p<0.001) but were significantly lower than RA patients with joint deformities (0.026). Sclerostin levels also correlated with CRP (r=0.328, p=0.012), Anti-CCP (r=0.418, p=0.001), tender joint count (r=0.293, p=0.025), and DAS28 (r=0.26, p=0.047). There was not a significant association with other variables such as ESR, and rheumatoid factor. By using receiver operating characteristic (ROC) curve, the best cut-off value of sclerostin was 249.69 pg/ml which showed (AUC 0.910, sensitivity 87.9%; specificity 93.3%) and [Odd Ratio (OR) Value & P-value: 102, P< 0.0001].Conclusion: Sclerostin can be used in addition to other parameters to diagnose RA as it was associated with RA with good sensitivity and specificity. It was also associated in early joint destruction and tenderness.

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Section: Introductionmentioning

confidence: 99%

“…Another inhibitor of that pathway is TNF-alpha, which also increases during in ammation and therefore RA. TNF-alpha stimulates osteoclasts and leads to an increase of the expression of DKK-1, another inhibitor of the Wnt pathway, and plays an important role in the stimulation of sclerostin production (14,21,26).…”

Section: Introductionmentioning

confidence: 99%

The role of sclerostin in rheumatoid arthritis in a Syrian population: a potential indicator of disease activity in newly-diagnosed patients

Hussein

Kakaje

Aboukhais

2022

Preprint

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The Diagnostic Significance of Serum Sclerostin in Early Detection of Rheumatoid Arthritis in Syrian Patients

Hussein,

Aboukhamis

2023

TORJ

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Background: Rheumatoid arthritis (RA) is associated with joint deformities and local bone erosions. Sclerostin is an inhibitor of the Wnt pathway and drives to reduce bone formation. Aims: Our study aimed to compare the diagnostic significance of sclerostin with anti-CCP (anti-cyclic citrullinated peptide; normal level<20 IU/ml, and rheumatoid factor (RF; normal level<16 IU/ml) for the early diagnosis of rheumatoid arthritis in Syrian patients. Methods: This study contained fifty-eight RA patients and thirty healthy individuals who were equally age- and sex-matched. Serum sclerostin and serum anti-CCP (IgG) levels were evaluated by using the enzyme-linked immunosorbent assay (ELISA). RA activity was assessed based on disease activity scores (DAS28). Results: Our results indicated that serum levels of sclerostin levels were higher in the RA group than in the healthy group (p<0.001). There was a positive correlation between serum sclerostin and DAS28-ESR (r=0.413, p=0.001). By ROC curve, the most optimal cut-off value of sclerostin was 249.69 pg/ml (AUC was 0.910 with 95% confidence interval (CI) values (0.852-0.969), sensitivity of 87.9%, and specificity of 93.3%) [Odds Ratio (OR) and P-value: 102, P< 0.0001]. In RA patients, the sensitivity and specificity of anti-CCP were 74.1% and 90%, and 70.6% and 86.6% of RF, respectively. Conclusion: Increased serum sclerostin may aid as a new prognostic biomarker for evaluating the activity of RA. Sclerostin showed higher sensitivity and specificity than anti-CCP and RF-IgM antibodies. Therefore, sclerostin is a sensitive and specific biomarker for early diagnosis of rheumatoid arthritis.

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Sclerostin and IL-1Ra in Rheumatoid Iraqi Patients after Biological Therapy

Cited by 2 publications

References 0 publications

The role of sclerostin in rheumatoid arthritis in a Syrian population: a potential indicator of disease activity in newly-diagnosed patients

The role of sclerostin in rheumatoid arthritis in a Syrian population: a potential indicator of disease activity in newly-diagnosed patients

The Diagnostic Significance of Serum Sclerostin in Early Detection of Rheumatoid Arthritis in Syrian Patients

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