(−)-Sclerosporin, an Antifungal Metabolite of<i>Diplocarpon mali</i>

Sawai, Ko; Okuno, Toshikatsu; Yoshikawa, Eriko

doi:10.1080/00021369.1985.10867117

Cited by 2 publications

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“…A new natural pyrrole-containing compound that was reported elsewhere by synthesis, namely, 1-(3,4,5-trimethyl-1 H -pyrrol-2-yl)ethan-1-one ( 193 ), and the sesquiterpene (−)-sclerosporin ( 194 ) were isolated from a Dactylaria sp. (strain G372) that was collected from submerged wood in a stream on the campus of the University of North Carolina at Greensboro, NC, in 2012.…”

Section: Part Ii: Chemical Diversity Of Freshwater Fungimentioning

confidence: 99%

Freshwater Fungi as a Source of Chemical Diversity: A Review

et al. 2021

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As their name indicates, freshwater fungi occur on submerged substrates in fresh water habitats. This review brings together the chemical diversity and biological activity of 199 of the 280 known freshwater fungal metabolites published from 1992 to 2020, representing at least seven structural classes, including polyketides, phenylpropanoids, terpenoids, meroterpenoids, alkaloids, polypeptides, and monosaccharides. In addition to describing what they are, where they are found, and what they do, we also discuss strategies for the collection, isolation, and identification of fungi from freshwater habitats, with the goal of enhancing chemists' knowledge of several mycological principles. We anticipate that this review will provide a springboard for future natural products studies from this fascinating but underexplored group of Ascomycota.

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Section: Part Ii: Chemical Diversity Of Freshwater Fungimentioning

confidence: 99%

Freshwater Fungi as a Source of Chemical Diversity: A Review

et al. 2021

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“…Sclerosporin was first isolated from Sclerotinia fructicula as an inducer of asexual arthrospore formation , and from Diplocarpon mali , the Marssonina apple blotch disease agent. , Sclerosporin has been reported in less than eight publications so far, half of them focused on the isolation of the compound and analogues from various fungal strains, ,, while the others are dedicated to chemical synthesis. − The sclerosporin family contains oxido-reduction derivatives of the original compound: sclerosporal was isolated from Sclerotinia fructicula , polygosumic acid was isolated from Polygonum viscosum , and four hydroxylated derivatives were isolated from Cadophora malorum .…”

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confidence: 99%

Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum

et al. 2019

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Colletotrichum higginsianum is the causal agent of crucifer anthracnose disease, responsible for important economic losses in Brassica crops. A mutant lacking the CclA subunit of the COMPASS complex was expected to undergo chromatin decondensation and the activation of cryptic secondary metabolite biosynthetic gene clusters. Liquid-state fermentation of the ΔcclA mutant coupled with in situ solidphase extraction led to the production of three families of compounds, namely, colletorin and colletochlorin derivatives with two new representatives, colletorin D (1) and colletorin D acid (2), the diterpenoid α-pyrone higginsianin family with two new analogues, higginsianin C (3) and 13-epi-higginsianin C (4), and sclerosporide (5) coupling a sclerosporin moiety with dimethoxy inositol.

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(−)-Sclerosporin, an Antifungal Metabolite ofDiplocarpon mali

Cited by 2 publications

References 1 publication

Freshwater Fungi as a Source of Chemical Diversity: A Review

Freshwater Fungi as a Source of Chemical Diversity: A Review

Deleting a Chromatin Remodeling Gene Increases the Diversity of Secondary Metabolites Produced by Colletotrichum higginsianum

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