Sclerosing Stromal Tumour of the Ovary Case Report With Endocrine Studies

Quinn, Michael; Øster, Anne; Fortune, Denys W.; Hudson, Bryan

doi:10.1111/j.1471-0528.1981.tb01032.x

Cited by 32 publications

(8 citation statements)

References 14 publications

(9 reference statements)

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“…Chalvardjian and Scully1) originally considered ovarian SSTs to be nonfunctioning tumors. However, some investigators have reported endocrine changes associated with secretion of estrogen and progesterone10) as wells as induction of precocious puberty11). Other symptoms include: pelvic pain, a palpable pelvic mass, metrorrhagia and menstrual irregularities including postmenopausal bleeding in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

et al. 2011

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A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain or a palpable abdominal mass. Hormonal effects such as masculinization are uncommon. Here, an 11-year old premenarchal girl presented with deepening of the voice. In addition, clitoromegaly and hirsutism with a male suprapubic hair pattern were observed. The laboratory findings showed that the testosterone level was elevated to 3.67 ng/mL, andostenedione to above 10 ng/mL, dehydroepiandrosterone-sulfate to 346 µg/dL and 17-hydroxy progesterone (17-OHP) to 11.28 ng/mL. The chromosome evaluation revealed a 46,XX female karyotype. An adrenocorticotropic hormone stimulation test was performed. The 17-OHP to cortisol ratio in 30 minutes was 0.045, which suggested a heterozygote for the 21-hydroxylase deficiency. However, the CYP21A2 gene encoding steroid 21-hydroxylase showed normal. The pelvic ultrasound showed a heterogeneous mass consisting of predominantly solid tissue in the pelvic cavity. The pelvic magnetic resonance imaging revealed an 8.9×6.2×6.6 cm mass of the left ovary. A left oophrectomy was performed and microscopic examination confirmed a sclerosing stromal tumor. Immunohistochemical studies showed that the tumor was positive for smooth muscle actin and vimentin, but negative for S-100 protein and cytokeratin. Following surgery, the hormone levels returned to the normal range and the hirsutism resolved.

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Section: Discussionmentioning

confidence: 99%

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

et al. 2011

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“…In our series, the patients presented with abdominal pain and/or menometrorrhagia. Most of the tumors are hormonally inactive, but some investigators have described endocrine alterations caused by secretion of estrogen, progesterone, or testosterone9, 10 as well as induction of precocious puberty 11. One of our cases had ascites and elevated CA‐125 levels, which is an uncommon feature of this neoplasm.…”

Section: Discussionmentioning

confidence: 99%

Fine needle aspiration cytology in sclerosing stromal tumor of the ovary: A series of three cases

Banik

Gupta

Dey

et al. 2011

Diagnostic Cytopathology

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Sclerosing stromal tumor (SST) of the ovary is a distinct subtype of sex cord-stromal tumor, which is derived from the ovarian stroma and, in turn, from the sex cords of the embryonic gonads. It is a benign tumor, predominantly, unilateral in nature and mostly involves the right side of the ovary. Histopathological features are characteristic and are well described in the literature; however to the best of our knowledge fine needle aspiration cytology (FNAC) has not been described previously. We present FNAC findings in a series of three cases of SST and discuss the cytomorphological features. We have described Call-Exner like bodies in one of our cases and hence, suggest that these may not be an exclusive feature of granulosa cell tumor.

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“…Therefore, plasma estrogen, progesterone, androgen, and tumor markers are not specific for the diagnosis of SSTO. An SSTO complicating pregnancy is rare; only a few cases have been reported to date, of which only one case involved an ectopic pregnancy [16]. In that case, an emergency laparotomy revealed a ruptured left ampullary pregnancy and a solid ovarian tumor approximately 3 cm in diameter on the right side; pathological findings confirmed the diagnosis of SSTO [16].…”

Section: Discussionmentioning

confidence: 80%

“…An SSTO complicating pregnancy is rare; only a few cases have been reported to date, of which only one case involved an ectopic pregnancy [16]. In that case, an emergency laparotomy revealed a ruptured left ampullary pregnancy and a solid ovarian tumor approximately 3 cm in diameter on the right side; pathological findings confirmed the diagnosis of SSTO [16]. An SSTO complicating a tubal pregnancy on the same side is also very rare; to date, case 2 in this study is the only reported example.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Management of Sclerosing Stromal Tumors of the Ovary Combined with Ectopic Pregnancy

Liu

Liu²,

Sun³

et al. 2015

Gynecol Obstet Invest

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Like other stromal-derived gynecological tumors, a sclerosing stromal tumor of the ovary (SSTO) is a rare benign tumor that is difficult to distinguish from a malignant ovarian tumor in clinical practice. An SSTO is routinely treated with laparotomy. Here, we present two extremely rare cases of SSTO with contralateral and ipsilateral tubal pregnancies, in which laparoscopic surgery was performed to remove the tumors. After surgery, one patient (case 1) became pregnant twice within 29 months, and the other patient (case 2) did not become pregnant within 6 months postoperatively. These two cases suggest that laparoscopic management is not only useful in treating SSTO and complicating diseases, but it may also help to reduce unnecessary surgical injury to the ovary.

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Sclerosing Stromal Tumour of the Ovary Case Report With Endocrine Studies

Abstract: Summary The findings in a patient who was found to have a sclerosing stromal tumour of the ovary associated with a tubal pregnancy are described. Measurement of hormones in blood before and after removal of the tumour suggested the tumour was andro‐gen‐secreting.

Cited by 32 publications

References 14 publications

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

Fine needle aspiration cytology in sclerosing stromal tumor of the ovary: A series of three cases

Laparoscopic Management of Sclerosing Stromal Tumors of the Ovary Combined with Ectopic Pregnancy

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