Sclerosing Stromal Tumor of the Ovary: A Case Report

Kuşçu, Esra; Öktem, M.; Karahan, Hilal B.; Bilezikçi, Banu; Demirhan, Beyhan

doi:10.1136/ijgc-00009577-200303001-00252

Cited by 4 publications

(4 citation statements)

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“…Only two cases of SST with virilization have been reported in premenarchal girls, with the age at presentation of 9 years[ 15 ] and 11 years[ 16 ]. Following removal of the tumor, the patient’s hormone levels can quickly recover to the normal range[ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Sclerosing stromal tumor of the ovary with masculinization, Meig’s syndrome and CA125 elevation in an adolescent girl: A case report

Chen¹,

Chen²,

Tang³

et al. 2020

WJCC

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BACKGROUND Sclerosing stromal tumor (SST) is an extremely rare sex cord stromal tumor of the ovary. It was first reported and named in 1973. These tumors typically present with pelvic/abdominal pain and tenderness, a mass, and/or abnormal menses, but rarely present with masculinity in children and adolescents. Only 2 cases of these tumors have been reported in premenarchal girls, who demonstrated hormonal activity, with a history of the development of a virilizing female due to hyperandrogenism. Here, we report a case of a giant SST with obvious masculinity combined with Meig’s syndrome and CA125 elevation. CASE SUMMARY A 17-year-old female presented with a 7-year history of the development of masculinity and a 2-year history of amenorrhea. She had hirsutism, acne, obvious laryngeal prominence, and voice deepening. Physical examination showed a male suprapubic hair pattern and a 4.0 cm × 1.5 cm enlarged clitoris. Laboratory tests showed that the testosterone level was > 15.00 ng/mL (normal range: 0.14-0.76 ng/mL), and androstenedione level was > 10.00 ng/mL (normal range: 0.3-3.3 ng/mL). A computed tomography scan of the abdomen and pelvis was carried out and showed a large, solid and cystic, partly calcified pelvic mass in the right ovary measuring 27.1 cm × 20.0 cm × 11.0 cm, 15 cm above the umbilicus (to the level of the upper part of L1). Intraoperative findings at laparotomy revealed a large tumor arising from the right ovary. Approximately, 500 mL of pale-yellow clear liquid was found in the pelvic cavity. A right salpingo-oophorectomy was performed. Microscopic examination and immunohistochemical staining of the surgical specimen showed an SST of the ovary. CONCLUSION This report is remarkable as our patient was not only diagnosed with an SST of the ovary, which is extremely rare in this age group, but was the largest and most obvious reported patient with this tumor who presented with virilization. Therefore, gynecologists should be aware of this potential complication in adolescent girls with a mass in the ovary.

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Section: Discussionmentioning

confidence: 99%

Sclerosing stromal tumor of the ovary with masculinization, Meig’s syndrome and CA125 elevation in an adolescent girl: A case report

Chen¹,

Chen²,

Tang³

et al. 2020

WJCC

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“…Lebensjahr auf und sind in der Regel hormonell inaktiv. Es gibt jedoch Einzelfallberichte von androgenbildenden sklerosierenden Stromatumoren [22]. In der Literatur finden sich 3 Fallberichte von virilisierenden sklerosierenden Stromatumoren des Ovars, die in der Schwangerschaft auftraten [23].…”

Section: E Granulosazelltumoren Bilden In Der Regel öStrogeneunclassified

Androgenproduzierende Tumoren

Hoellen

Noack

Ribbat

et al. 2011

Gynäkologische Endokrinologie

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“…Adneksiyal kitle ile ilişkili nonspesifik semptomlar ve menstrüel düzensizlikler en sık görülen yakınmalardır. Genelde tek taraflı ve solid gelişim gösterirler (3)(4)(5). Sklerozan stromal tümör benign bir neoplazi olup postoperatif patolojik incelemede tanı alır.…”

Section: Introductionunclassified

Sclerosing stromal tumor of the ovary in a postmenopausal woman: case report

Hasçiçek¹,

Sarı²,

Kabukçuoğlu³

2017

Sisli Etfal

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Postmenopozal kadın hastada overde sklerozan stromal tümör: Olgu sunumu Amaç: Overin sklerozan stromal tümörü, over tümörleri içinde oldukça nadir, benign karakterli en sık 2.-3. dekatta görülen bir tümördür. 54 yaşında karında şişlik şikayetiyle ile başvuran, unilateral overin sklerozan tümörü tanısı alan olguya ait klinik, histopatolojik ve immunohistokimyasal bulgular literatür eşliğinde sunulmuştur. Olgu: Histopatolojik olarak fokal skleroz alanları içeren ödemli stromanın oluşturduğu psödolobüler görünüm, heterojen hücre populasyonu ve belirgin vaskülarizasyon ile karakterize lezyon izlendi. Sonuç: Overin sklerozan stromal tümörü, en sık 2.-3. dekatta görülür ancak postmenopozal hastalarda da rastlanılabileceği akılda tutulmalıdır.

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Sclerosing Stromal Tumor of the Ovary: A Case Report

Cited by 4 publications

References 0 publications

Sclerosing stromal tumor of the ovary with masculinization, Meig’s syndrome and CA125 elevation in an adolescent girl: A case report

Sclerosing stromal tumor of the ovary with masculinization, Meig’s syndrome and CA125 elevation in an adolescent girl: A case report

Androgenproduzierende Tumoren

Sclerosing stromal tumor of the ovary in a postmenopausal woman: case report

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