Sclerosing stromal tumor of the ovary in a premenarchal female

Fefferman, Nancy R.; Pinkney, Lynne; Rivera, Rafael; Popiolek, Dorota; Ph, Levine; Cosme, Jaqueline

doi:10.1007/s00247-002-0694-7

Cited by 18 publications

(19 citation statements)

References 7 publications

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“…Rare cases have been described in adolescent girls, as early as 10 years of age [2]. To our knowledge, the 7-month-old patient on whom we report represents the youngest instance of an OSST to be documented in the literature.…”

Section: Discussionmentioning

confidence: 65%

Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

et al. 2008

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This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia-like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.

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Section: Discussionmentioning

confidence: 65%

Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

et al. 2008

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“…Sclerosing stromal tumor (SST) is a benign stromal tumor of the ovary. Imaging findings and histopathological results in SST are well described in the literature [1][2][3][4]. However, there are no reports regarding elastography findings in SST.…”

Section: Introductionmentioning

confidence: 90%

Sclerosing stromal tumor of the ovary: ultrasound elastography and MRI findings on preoperative diagnosis

2011

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Sclerosing stromal tumor (SST) is a benign stromal tumor of the ovary. Preoperative diagnosis of this benign tumor mainly depends on imaging findings. Dynamic computed tomography (CT) and magnetic resonance imaging (MRI) show typical contrast enhancement of SST with peripheral enhancement in the early phase and centripetal progression in the delayed phases. We present the imaging findings of ultrasonography, ultrasound elastography, and dynamic MRI in the diagnosis of SST. Abdominal ultrasound elastography is a novel technique that depicts the stromal structure of SSTs by comparing the elasticity of the tumor and the myometrium using quantitative strain values.

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“…Since its first description in 1973 by Chalvardjian and Scully1), fewer than 100 cases have been reported2). The tumor occurs predominantly during the second and third decades of life with a mean age of 28 years3). Most of the reported cases have described women 14 years of age or older that have undergone menarche, except for three cases involving premenarchal girls2-4).…”

Section: Introductionmentioning

confidence: 99%

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

et al. 2011

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A sclerosing stromal tumor of the ovary is an extremely rare benign tumor; it usually is found during the second and third decades of life. Patients present with pelvic pain or a palpable abdominal mass. Hormonal effects such as masculinization are uncommon. Here, an 11-year old premenarchal girl presented with deepening of the voice. In addition, clitoromegaly and hirsutism with a male suprapubic hair pattern were observed. The laboratory findings showed that the testosterone level was elevated to 3.67 ng/mL, andostenedione to above 10 ng/mL, dehydroepiandrosterone-sulfate to 346 µg/dL and 17-hydroxy progesterone (17-OHP) to 11.28 ng/mL. The chromosome evaluation revealed a 46,XX female karyotype. An adrenocorticotropic hormone stimulation test was performed. The 17-OHP to cortisol ratio in 30 minutes was 0.045, which suggested a heterozygote for the 21-hydroxylase deficiency. However, the CYP21A2 gene encoding steroid 21-hydroxylase showed normal. The pelvic ultrasound showed a heterogeneous mass consisting of predominantly solid tissue in the pelvic cavity. The pelvic magnetic resonance imaging revealed an 8.9×6.2×6.6 cm mass of the left ovary. A left oophrectomy was performed and microscopic examination confirmed a sclerosing stromal tumor. Immunohistochemical studies showed that the tumor was positive for smooth muscle actin and vimentin, but negative for S-100 protein and cytokeratin. Following surgery, the hormone levels returned to the normal range and the hirsutism resolved.

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Sclerosing stromal tumor of the ovary in a premenarchal female

Cited by 18 publications

References 7 publications

Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

Study of an Ovarian Sclerosing Stromal Tumor Presenting as Vaginal Bleeding in a 7-Month-Old

Sclerosing stromal tumor of the ovary: ultrasound elastography and MRI findings on preoperative diagnosis

A sclerosing stromal tumor of the ovary with masculinization in a premenarchal girl

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