Sclerosing peritonitis, a rare complication after intestinal transplant. Report of one case successfully treated with adjustment of immunosuppression

Abstract

Sclerosing peritonitis is a complication described in different clinical situations, such as patients that underwent prolonged peritoneal dialysis or renal transplantation with previous history of peritoneal dialysis. The origin of this entity is unclear so far and it is believed that several mechanisms may contribute to its development. The hallmark of sclerosing peritonitis is the continuous accumulation of fibrocollagenous deposits in the intestinal wall and mesenteries causing progressive adhesion of the intestinal loops and mesenteric retraction resulting in intestinal obstruction. Also, it has been described as a rare complication after intestinal transplant that might lead to graft failure. In this report, we describe a case of sclerosing peritonitis after intestinal transplantation that was successfully treated with modifications in the immunosuppressive regime allowing restitution of gastrointestinal transit and intestinal autonomy.

Sclerosing peritonitis post liver transplantation: a rare condition where surgery is an important treatment option

“…There has only been one previous case report where SP was diagnosed many years following OLT, which was similar to our overall experience. Of note, de novo SP has similarly been described occurring months to years following small bowel transplantation . The three patients in this series, two of whom had SP confirmed at laparotomy, were all diagnosed well over a year post OLT.…”