Sclerosing Orbital Pseudotumor

Cervellini, P.; Volpin, Lorenzo; Curri, D; Pedrotti, M.; Benedetti, A

doi:10.1159/000309677

Cited by 19 publications

(7 citation statements)

References 8 publications

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“…The presence of sclerosing disease was indicated when dense fibrous connective tissue with hardening of the normal tissue is the predominant component of the specimen. Sclerosis suggested the histopathological end stage of IOI19 20 or a unique disease entity 21. In either case, sclerosing disease often indicated the presence of a more aggressive disease process with a poorer therapeutic outcome, compared with the non-sclerosing forms of the disease.…”

Section: Discussionmentioning

confidence: 99%

Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease

2015

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Section: Discussionmentioning

confidence: 99%

Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease

2015

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“…Based on a search of the American literature, 15–20 this is a rare presentation and should help alert clinicians to be mindful of ISOI with an abnormal sinusitis presentation. To date, there is still little known as to what causes this disease to affect patients or what causes it to become inactive.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Sclerosing Inflammation Presenting as Sinusitis

Barham

Dishop

Prager

2012

Allergy�Rhinol (Providence)

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Idiopathic sclerosing orbital inflammation is a rare finding that is poorly delineated, immune mediated, and causes severe symptoms and disability. It has been described affecting the orbit in addition to other sites within the head and neck, but has rarely been described presenting as sinusitis. A case report and literature review were performed. A 14-year-old girl with right-sided face and eye pain and pressure for >1 month presented 3 days after endoscopic sinus surgery for presumed acute sinusitis. She subsequently developed ipsilateral vision loss and hypesthesia of the infraorbital nerve. MRI revealed a mildly enhancing soft tissue intensity lesion extending from the right maxillary sinus into the pterygopalatine fossa and orbital apex through the inferior orbital fissure. Biopsy specimens of the lesion were consistent with a sclerosing inflammatory lesion. High-dose steroids led to rapid improvement in vision and pain; however, the patient was unable to tolerate steroid weaning because of recurrence of eye pain and headache. Repeat imaging showed progression of the lesion. Rheumatology was consulted and the patient's steroid therapy was altered and her medications were expanded to include azathioprine. The patient's symptoms improved and subsequent imaging showed a reduction in the size and extent of the lesion. Idiopathic sclerosing inflammation is characterized by primary, chronic, and immunologically mediated fibrosis. Patients typically have a poor response to corticosteroid treatment or radiotherapy. Immunosuppressive therapy in addition to corticosteroids is the recommended treatment.

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“…No entanto, a histopatologia clássica envolve infiltrado de linfócitos esparsos, células plasmáticas e histiócitos, com preservação da arquitetura do tecido afetado (15) . Alguns autores consideram a forma esclerosante como estágio terminal de um continuum histopatológico do pseudotumor orbitário, caracterizado por componente maior de linfócitos no estágio inicial, passando para uma fase de fibrose progressiva, em um estágio mais crônico (16) . Outros, entretanto, acreditam se tratar de doenças distintas (17) .…”

Section: Discussionunclassified

Pseudotumor orbitário em paciente com doença de Still do adulto: associação incomum

Scalcon¹,

Cunha²,

Rossi³

et al. 2008

Rev. Bras. Reumatol.

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A doença de Still do adulto é uma desordem inflamatória rara, caracterizada por picos febris diários, rash evanescente, artrite e envolvimento de múltiplos órgãos. Manifestações oculares têm sido descritas associadas às manifestações clínicas clássicas da doença. Será descrito um caso de pseudotumor orbitário, condição clínica incomum, em uma paciente com diagnóstico de doença de Still do adulto.

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Sclerosing Orbital Pseudotumor

Cited by 19 publications

References 8 publications

Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease

Implications of enlarged infraorbital nerve in idiopathic orbital inflammatory disease

Idiopathic Sclerosing Inflammation Presenting as Sinusitis

Pseudotumor orbitário em paciente com doença de Still do adulto: associação incomum

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