Sclerosing Odontogenic Carcinoma with Local Recurrence: Case Report and Review of Literature

Todorovic, Emilija; Berthelet, Eric; O’Connor, Robert; Durham, J.S.; Tran, Eric; Martin, M.; Hayes, Malcolm; Ng, Tony

doi:10.1007/s12105-018-0975-6

Cited by 25 publications

(23 citation statements)

References 17 publications

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“…CK19 is a low molecular weight cytokeratin and often highlights epithelial cells near the surface epithelium or squamous differentiation. 23 This marker, however, was unexpectedly negative in the case reported by Todorovic et al 7 More clarifications of cytokeratin subtype staining would be beneficial to identify the expression of cytokeratin pertaining to its histogenesis. Predictive biomarkers such as Ki-67 that are widely used to gauge the proliferative index of a tumor appeared to be a non-significant finding for SOC.…”

Section: Discussionmentioning

confidence: 93%

“…This may be related to the low-grade characteristics of epithelial and stromal components, including their low mitotic activity. 7 Saxena et al 25 also postulated that the dense stroma surrounding the epithelial component of the tumor may have a role in preventing metastasis. The role of adjuvant treatment cannot be justified at the moment.…”

Section: Discussionmentioning

confidence: 99%

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Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

Lim

Tan

Tilakaratne

et al. 2022

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

Lim

Tan

Tilakaratne

et al. 2022

Brazilian Journal of Otorhinolaryngology

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“…Depression on the palatal gingiva attributed to bone perforation and collapse was seen in one case of SOC 12 and some cases of COdF, 13 whilst neurological signs were absent occasionally in SOC 6, 14 and usually in COdF 13 . Presentation as a destructive osteolytic lesion is common in SOC 15 and large COdFs of the maxilla 13, 16 …”

Section: Discussionmentioning

confidence: 99%

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

et al. 2022

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Aim To present a maxillary tumour showing features of sclerosing odontogenic carcinoma (SOC), i.e. bland cytology, partly sclerotic stroma and neural involvement, and contemplate whether its diagnostic feature, neural involvement, could represent epithelial neurotropism in a central odontogenic fibroma (COdF). Materials and methods A 58‐year‐old male presented with a depression on the palatal side of the alveolar ridge, extending from the right canine to the right first molar tooth. A CBCT of the maxilla revealed a multilocular radiolucency, with ill‐defined borders, causing destruction of the buccal and palatal cortical bone. Results Complete removal of the tumour was performed under general anaesthesia. Healing was uneventful and there was no evidence of recurrence in the 36 months clinical and radiographical follow up. The final diagnosis was an odontogenic tumour with bland cytology, sclerosis and neural involvement, consistent with SOC. Conclusions The tumour presented herein showed clinical, radiographical and microscopical features consistent with SOC and COdF, with neural involvement favouring a diagnosis of SOC. Epithelial neurotropism in a COdF could account for the similarities between those lesions and the rather quiescent, for an infiltrative intraosseous carcinoma, clinical behaviour of SOC.

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“…Clinically, SOC is an expansile mass that sometimes results in nerve symptoms. It is associated with osteolysis, variable cortical destruction, sclerotic changes, ground-glass appearance of the involved bone, a wholly or partially ill-defined border, and tooth resorption evident on panoramic x-ray [ 19 , 20 ]. In the current case, the border of the lesion was clear, there were no sclerotic changes or clinical symptoms.…”

Section: Discussionmentioning

confidence: 99%

Amyloid Variant of Central Odontogenic Fibroma in the Mandible: A Case Report and Literature Review

2020

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Patient: Male, 35-year-old Final Diagnosis: Central odontogenic fibroma Symptoms: Asymptomatic Medication:— Clinical Procedure: Enucleation • surgery removal Specialty: Dentistry Objective: Rare disease Background: Odontogenic fibroma is a rare mesenchymal odontogenic tumor. It can be classified as central odontogenic fibroma (COF) or peripheral odontogenic fibroma (POF) based on clinical features. There are several variants of COF, including amyloid, ossifying, and giant cell. It grows slowly and exhibits painless cortical expansion of the jawbone. Radiographically, COF appears as a radiolucent unilocular or multilocular lesion with well-defined borders. COF may be associated with unerupted or displaced teeth and root resorption. Case Report: A 35-year-old man was referred to our hospital for submandibular swelling. Panoramic radiography and contrast-enhanced computed tomography revealed a unilocular area of bone resorption with a well-defined border and equal enhancement from the canine to first molar on the right side of the mandible. Root resorption of the first premolar and root separation of the first and second premolars were also evident. The lesion was asymptomatic. Histopathological examination of a biopsy of the lesion was suggestive of OF. Enucleation of the tumor, curettage of the bone around the tumor, and extraction of the premolar were then performed. Histopathological examination of the tumor showed fibrous connective tissue with inactive-looking odontogenic epithelial islands and strands, amyloid deposit, intercalation of Langerhans cells into the tumor epithelium, and no calcification. The final diagnosis of amyloid variant of COF was made. The postoperative course is going well. Conclusions: Herein we describe and discuss the clinical, radiological, and pathological features of the amyloid variant of COF. This report will enhance understanding of this extremely rare variant.

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Sclerosing Odontogenic Carcinoma with Local Recurrence: Case Report and Review of Literature

Cited by 25 publications

References 17 publications

Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

Amyloid Variant of Central Odontogenic Fibroma in the Mandible: A Case Report and Literature Review

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