Sclerosing odontogenic carcinoma with local recurrence and lymph node metastasis

Fukui, Rei; Yamamoto, Akira; Tsunoda, Mariko; Matsumoto, Kunihito; Namaki, Shunsuke; Asano, Masaharu

doi:10.1016/j.pathol.2023.01.011

Cited by 2 publications

(8 citation statements)

References 9 publications

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“…SOC is typically recognized as a locally aggressive yet slow-growing tumor, generally characterized by an indolent clinical course. Apart from the case reported by Fukui et al [ 5 ], no lymph node or distant organ metastasis instances have been documented in SOC cases. While the bilateral pulmonary masses detected by 18FDG-PET/CT strongly indicated metastatic lesions of SOC, the masses were not histologically examined.…”

Section: Discussionmentioning

confidence: 71%

“…Owing to its rarity and indolent nature, some authors have questioned the legitimacy of SOC as a malignancy [ 1 ]. A recent report of recurrence and lymph node metastasis [ 5 ] illustrated the true malignant nature of SOC. In addition, the complex histological findings of SOC, which occasionally share histological characteristics with CCOC [ 5 , 9 ], make the diagnosis challenging.…”

Section: Discussionmentioning

confidence: 99%

“…A recent report of recurrence and lymph node metastasis [ 5 ] illustrated the true malignant nature of SOC. In addition, the complex histological findings of SOC, which occasionally share histological characteristics with CCOC [ 5 , 9 ], make the diagnosis challenging. The current case may be the first report of SOC with a fatal clinical course and perineural and vascular invasion.…”

Section: Discussionmentioning

confidence: 99%

“…They doubted the legitimacy of SOC as a malignancy. Fukui et al reported a case of SOC with solitary lymph node metastasis, suggesting its metastatic potential [ 5 ]. To clarify the biological nature of SOC, it will be necessary to accumulate more cases.…”

Section: Introductionmentioning

confidence: 99%

“…Sclerosing odontogenic carcinoma (SOC) is an extremely rare odontogenic malignancy. Only 22 cases were reported in the English-language medical literature from 2008 to 2023 [1][2][3][4][5][6]. SOC is characterized by thin cords or strands of bland odontogenic epithelium infiltrating the prominent fibrous stroma [7].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sclerosing Odontogenic Carcinoma With a Prominent Clear Cell Component Mimicking Odontogenic Clear Cell Carcinoma: An Extremely Rare Case With a Fatal Clinical Outcome

Shen,

Shimada,

Roy

et al. 2024

Cureus

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Sclerosing odontogenic carcinoma (SOC) is an exceedingly rare odontogenic carcinoma known for its locally aggressive yet indolent behavior. There have been no reports of metastasis to distant organs, except a single case involving lymph node metastasis. This report details the case of a 49-year-old female who presented with a well-demarcated radiolucent lesion in the mandible, accompanied by root resorption and tooth displacement. Microscopically, the lesion exhibited a distinctive composition, with two distinct components: cords of epithelium embedded within an abundant collagenous stroma and solid nests of clear polygonal cells surrounded by hyalinized stroma. Notably, the tumor exhibited direct invasion into the submental muscles, accompanied by perineural and vascular invasion, as well as cortical bone loss. Additionally, the clear cells contained diastase-sensitive periodic acid-Schiff-positive granules. Immunohistochemically, the tumor cells displayed positivity for cytokeratin 19 and p63 while testing negative for myoepithelial markers. The Ki-67 index was measured at 23%. Importantly, neither EWSR1 nor MAML2 rearrangements were detected through fluorescence in situ hybridization (FISH) analysis. Over several years, this patient experienced three instances of local recurrence; notably, four years after the initial surgery, fludeoxyglucose F18-positron emission tomography (18FDG-PET)/CT scans confirmed the presence of pulmonary metastasis. This case presents an unusual histological variation of SOC, marked by vascular invasion, and is notably the first documented case of a fatal outcome in this context.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Sclerosing Odontogenic Carcinoma With a Prominent Clear Cell Component Mimicking Odontogenic Clear Cell Carcinoma: An Extremely Rare Case With a Fatal Clinical Outcome

Shen,

Shimada,

Roy

et al. 2024

Cureus

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A case of sclerosing odontogenic carcinoma of the mandible with a review of the literature

Kinoshita,

Tomioka,

Oikawa

et al. 2023

J Oral Sci

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Sclerosing odontogenic carcinoma (SOC) is a very rare malignant odontogenic tumor characterized by sclerotic stroma and singlefile cord-like tumor cell structures. A 38-year-old man presented with extraoral swelling and right mental region paralysis. Panoramic radiography revealed an ill-defined radiolucent lesion extending from the right mandibular ramus to the right lower canine. Magnetic resonance imaging showed tumor invasion into the right inferior alveolar nerve and masseter muscle. Hemimandibulectomy, bilateral neck dissection, and mandibular reconstruction were performed using a rectus abdominis musculocutaneous flap and a titanium plate. Histopathology and immunohistochemistry confirmed SOC diagnosis. No recurrence occurred in the 1-year follow-up. In this paper, a case of SOC with a high Ki-67 labeling index was reported. Since SOC is prone to nerve invasion, treatment is resection with an appropriate surgical margin.

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Sclerosing odontogenic carcinoma with local recurrence and lymph node metastasis

Cited by 2 publications

References 9 publications

Sclerosing Odontogenic Carcinoma With a Prominent Clear Cell Component Mimicking Odontogenic Clear Cell Carcinoma: An Extremely Rare Case With a Fatal Clinical Outcome

Sclerosing Odontogenic Carcinoma With a Prominent Clear Cell Component Mimicking Odontogenic Clear Cell Carcinoma: An Extremely Rare Case With a Fatal Clinical Outcome

A case of sclerosing odontogenic carcinoma of the mandible with a review of the literature

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