Sclerosing microcystic adenocarcinoma of the tongue: a report of 2 further cases and review of the literature

Sclerosing Microcystic Adenocarcinoma: Report of a Rare Case and Review of Literature

“…The majority patients are females (8 of 10 cases) with a wide range of age (41-73 years). From the limited case reports and series of this rare entity, patients appear to have relatively indolent clinical courses without lymph node or distant metastasis (Table 1) [3][4][5][6]. Our patient underwent radiotherapy due to a focally positive margin without recurrence for 10 months.…”

“…Mills et al recently reported five such cases and named them "sclerosing microcystic adenocarcinoma" as a distinct entity [3]. Since then, two additional cases of sclerosing microcystic adenocarcinoma of head neck mucosa have been reported [6].…”

Sequencing of Sclerosing Microcystic Adenocarcinoma Identifies Mutational Burden and Somatic Variants Associated With Tumorigenesis

“…To our knowledge, this is the first study to profile SMA at the molecular level (1,6). Previous studies have attempted molecular characterization of MAC; SMA has often been described as a variant of MAC owing to its histological resemblance to sweat glands and infiltrative pattern and tendency toward perineural invasion but with a more favorable prognosis (1)(2)(3)8). Mutations have been identified in CDKN4/6 and also in TP53 and JAK1 genes in approximately 20% of patients with MAC (9, 10).…”

Microcystic Adenocarcinoma: An Initially Overlooked First Proposal of the Term

“…To the Editors, Our attention has been drawn to the recent report by Zhang et al [1], describing a single additional case of sclerosing microcystic adenocarcinoma, bringing to nine the number of examples documented in the English language literature [2][3][4][5]. Although the term "microcystic adenocarcinoma" was originally attributed to Mills et al [4] in 2016 [1,5], it is pertinent to make a few comments here on the first proposal of this entity in 2008 by Rosebush et al [6] that escaped the attention of the vast majority of pathologists.…”

“…Following a report by Johnston and Toker [7] in 1982, a number of definite or possible cases of salivary microcystic adenocarcinoma with sclerosing features were documented under a variety of names [1][2][3][4][5][6][8][9][10]. Without much supportive rationale, sclerosing microcystic adenocarcinoma is now only the designation that has survived this terminological conundrum [1,5]. Readers interested in the previously discarded terms are referred to two review articles [5,9].…”