Sclerosing Lipogranuloma Resulting from Exogenous Lipids

NEWCOMER, D.

doi:10.1001/archderm.1956.01550040055008

Cited by 63 publications

(17 citation statements)

References 12 publications

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“…Histologically, cystic spaces of various sizes are seen throughout dense fibrous tissue with a chronic granulomatous inflammatory reaction. These aggregates of empty vacuoles seen on hematoxylin-eosin staining represent lakes of the injected foreign, oily substance [9]. This overall reaction forms as human tissue lacks the appropriate enzymes to degrade the injected substance, thereby inciting a foreign-body reaction [3].…”

Section: Discussionmentioning

confidence: 99%

Penile paraffinoma: the delayed presentation

2007

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The injection of foreign substances into the penis for the purpose of augmentation may result in erectile dysfunction, voiding difficulties, and severe deformity. We report a case of penile paraffinoma in a 71-year-old man that developed nearly 40 years after undergoing a series of penile injections with an unknown substance. Penile paraffinoma can therefore present a diagnostic dilemma given its protracted latency period, after which time the initial injections have faded into distant memory.

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Section: Discussionmentioning

confidence: 99%

Penile paraffinoma: the delayed presentation

2007

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“…The first use of mineral oil injection for cosmetic purpose was described by Gersuny in 1899 and involved the scrotal injection of paraffin oil in a young male [1]. Throughout the latter half of the 20th century, various case reports emerged, describing the complications related to local inflammatory reactions from the subcutaneous injection of paraffin oil at various body sites (penis, breast, cheek, eyelids and nose) [2][3][4][5]. Acute pneumonitis from mineral oil embolism has been sporadically reported after the intentional or accidental injection of mineral oil or as a complication of lymphangiography [6].…”

Section: Discussionmentioning

confidence: 99%

A 26-year-old transsexual male with acute respiratory distress and haemoptysis

Blewett

Girod

2005

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A 26-year-old male pre-operative transsexual presented to the emergency dept of the University of Texas Southwestern Medical Center (TX, USA) with complaints of acute dyspnoea and frank haemoptysis. The patient did not use intravenous or illicit drugs, alcohol or tobacco, but had a history of unprotected homosexual intercourse. On physical examination, the patient was in severe respiratory distress, with a respiratory rate of 38 breaths per minute and accessory muscle use. The physical examination revealed subcutaneous emphysema, diffuse bilateral crackles, and mediastinal crepitus consistent with a Hamman's crunch. The patient had decreased facial and body hair, moderate breast augmentation and male genitalia. Arterial blood gases on room air revealed a pH 7.43, carbon dioxide tension (PCO 2 ) 4.66 kPa (35 mmHg), arterial oxygen tension (Pa,O 2 ) 4.39 kPa (33 mmHg) and 65% saturation. The patient was placed on a high-flow oxygen mask (non-rebreather mask), and subsequent arterial blood gases showed a pH 7.43, PCO 2 5.05 kPa (38 mmHg), Pa,O 2 7.98 kPa (60 mmHg) and 89% saturation.Laboratory data revealed a haematocrit of 27% (0.27), a normal white blood cell count and an unremarkable coagulation profile. Serum chemistries revealed an elevated lactic dehydrogenase of 252 U·L -1 (normal range 100-190 U·L -1 ). A urinary toxicology screen was negative for cocaine or opiates. The patient was empirically treated for Pneumocystis carinii pneumonia (PCP) and severe community-acquired pneumonia, with intravenous methylprednisolone, trimethoprim/sulphamethoxazole and ticarcillin/clavulanate.Blood, sputum and urine bacterial cultures were negative. Sputum samples were negative for P. carinii by direct fluorescent antibody and stains for acid-fast bacilli (AFB). An HIV antibody test was negative. The CD4 count was 103 cells·mm -3 (normal range 416-1,751 cells·mm -3 ) and HIV viral load was <400 copies·mL -1 (limit of detection <400 copies·mL -1 ). Serial bronchoalveolar lavage (BAL) revealed increasingly bloody returns consistent with diffuse alveolar haemorrhage. The first aliquot contained 465,000 red blood cells·µL -1 and 800 nucleated cells·µL -1 (67% neutrophils, 25% monocytes, 3% lymphocytes, 2% mesothelial cells, 3% eosinophils), while aliquot number four contained 510,000 red blood cells·µL -1 and 300 nucleated cells·µL -1 (77% neutrophils, 15% monocytes, 2% lymphocytes, 3% mesothelial cells, 2% eosinophils). BAL stains were negative for PCP, AFB, and fungal and bacterial pathogens. Serum anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibodies were negative.A computed tomography (CT) scan was performed on the patient and is shown in figure 1. The patient's original BAL fluid was further examined with Sudan stain and an example of this is shown in figure 2.

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“…The practice has continued in some parts of the world as evidenced by reports from some Asian and Eastern European countries 3 . The term ‘paraffinoma’ has been suggested by Newcomer and Graham for cases in which vegetable or mineral oils have induced sclerosing lipogranuloma 4 . Only paraffinoma case reports are usually published in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…3 The term 'paraffinoma' has been suggested by Newcomer and Graham for cases in which vegetable or mineral oils have induced sclerosing lipogranuloma. 4 Only paraffinoma case reports are usually published in the literature. There are only few studies discussing the sexual, emotional and psychological status of men who augmented their penis with mineral oil injection.…”

Section: Introductionmentioning

confidence: 99%