Sclerosing angiomatoid nodular transformation of spleen in a 3-year-old child

Zhang, Shouhua; Yang, Wenping; Xu, Hongyan; Wu, Zhuqiang

doi:10.1007/s13312-015-0776-x

Cited by 16 publications

(11 citation statements)

References 8 publications

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“…In previous literatures, SANT mainly occurs in middle-aged population with a slightly female inclination and the mean age at onset was 50 years, which is also supported in our case [5]. However, occurrence of SANT shows a young age trends in recent report [6,7]. Youngest SANT patient was a 7-month-old infant with splenomegaly [8].…”

Section: Discussionsupporting

confidence: 86%

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Yang

Zhang

Peng

et al. 2020

Preprint

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BACKGROUND: Sclerosing angiomatoid nodular transformation of the spleen is one kind of exceedingly rare benign lesions originated from spleen. The incidence and pathogen remain unclear partially due to its rarity and short history. Consequently, preoperative diagnosis become extremely perplex. Splenectomy is a predominated therapy approach as well as diagnosis method for sclerosing angiomatoid nodular transformation of the spleen. We reported a case underwent computed tomography scan, magnetic resonance imaging and ultrasonic scan preoperatively. Examinations conclusion highly suspected sclerosing angiomatoid nodular transformation of the spleen and was confirmed by pathology after laparoscopic splenectomy. We herein reviewed some literatures on imaging characters of to reveal the possibility of preoperative diagnosis when clinicians encounter and investigated whether laparoscopic splenectomy is an appropriate treatment.CASE PRESENTATION: A 50-year-old female was found with a low dense mass in the spleen by abdominal computed tomography incidentally without any positive symptom. Further enhanced computed tomography scan revealed the lesion with asynchronous enhancement and magnetic resonance imaging showed radio-like rift missing from central. Ultrasonic scan imaging presented hypoechoic gap in the center, pretty similar to magnetic resonance imaging. These radiology imaging features deduced to Sclerosing angiomatoid nodular transformation of the spleen. Laparoscopic splenectomy was performed successfully by our team and histopathological findings convinced the preoperative diagnosis. Gross inspection was coincident to the performance of magnetic resonance imaging.CONCLUSION: By comprehending imaging character profoundly, sclerosing angiomatoid nodular transformation of the spleen can be a differential diagnosis preoperatively when encounter lesion of spleen. We believe that laparoscopic splenectomy is a reliable and effective therapy option for such rare benign lesion of spleen without risk of recurrence.

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Section: Discussionsupporting

confidence: 86%

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Yang

Zhang

Peng

et al. 2020

Preprint

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“…Moreover, the phenotype of blood vessels in splenic hamartoma differs from SANT. The vascular spaces of SANT comprise various nature vessels (capillary, sinusoids, and veins) with a specific phenotype; on the opposite, vascular tumors show vessels with a monotonous phenotype, with variable features of malignancy, ranging from hemangioma [ 14 ] and lymphangioma to hemangioendothelioma and angiosarcoma. Although rare, SANT is a diagnostic entity to be taken into account among splenic nodular lesions, with well-established diagnostic features.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

Cipolla

Florena

Ferrara

et al. 2018

Case Reports in Surgery

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Introduction Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular lesion with unknown etiopathogenesis and with definite features of imaging, histopathology, and immunohistochemistry. It was first described by Martel et al. in 2004, and to date, only 151 cases have been reported. Case Description We report a case of SANT of the spleen detected in a 66-year-old Caucasian, without comorbidities, presented to our department with epigastric pain. We, also, presented a review of the literature. Conclusions SANT is a benign incidentally vascular condition in the majority of cases. The wide age and gender distribution in our review is in accordance with that in previous studies in English literature. In our opinion, splenectomy is the choice treatment because it is at the same time diagnostic and therapeutic in a definitive way.

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“…With improvement in the understanding of splenic function, more and more surgeons are currently opting for partial splenectomy in selected patients. 8 LPS, with intraoperative frozen section examination to exclude malignancy, was performed successfully in 13 patients in our sample. No patient had recurrence during follow-up, showing that partial splenectomy with adequate margin is sufficient and effective treatment for SANT of spleen.…”

Section: Discussionmentioning

confidence: 99%

Treatment options for sclerosing angiomatoid nodular transformation of spleen

Jin

Regmi

et al. 2020

HPB

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Background: To summarise the clinical features of Sclerosing angiomatoid nodular transformation (SANT) of the spleen and to compare the efficacy of three different surgical treatments.Methods: We performed a retrospective analysis of patients with SANT of spleen treated at our center from 2009 to 2018. We compared the efficacy and safety of three different types of surgical procedures.ANOVA and the chi-square test were used for statistical analysis.Results: A total of 37 patients were included. Most (35/37; 94.6%) were asymptomatic. A number presented as obscure boundary lesions such that malignancy could not be excluded. Open splenectomy was performed for 12 patients, laparoscopic splenectomy for 12 patients and laparoscopic partial splenectomy for 13 patients. Operation time (P = 0.355), blood loss (P = 0.135), length of hospital stay after operation (P = 0.271) and postoperative complications (P = 0.502) were comparable between the three groups. Duration of drainage tube placement was significantly longer in laparoscopic partial splenectomy patients (P = 0.006). Peak platelet count after operation was significantly lower in laparoscopic partial splenectomy patients (P < 0.001). Conclusion:Laparoscopic partial splenectomy appears to be a technically feasible and therapeutically effective approach for SANT.

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Sclerosing angiomatoid nodular transformation of spleen in a 3-year-old child

Abstract: Sclerosing angiomatoid nodular transformation can occur in early childhood.

Cited by 16 publications

References 8 publications

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Sclerosing Angiomatoid Nodular Transformation of the Spleen, a Rare Cause for Laparoscopic Splenectomy: a Case Report and Literature Review

Sclerosing Angiomatoid Nodular Transformation: Laparoscopic Splenectomy as Therapeutic and Diagnostic Approach at the Same Time

Treatment options for sclerosing angiomatoid nodular transformation of spleen

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