Scleritis and Episcleritis following Coronavirus Disease (COVID-19) Vaccination

Sanjay, Srinivasan; Handa, Ashit; Kawali, Ankush; Shetty, Rohit; Mishra, Sai Bhakti; Mahendradas, Padmamalini

doi:10.1080/09273948.2023.2182324

Cited by 4 publications

(7 citation statements)

References 41 publications

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“…Feizi et al 25 reported 2 cases of anterior scleritis after the resolution of the systemic symptoms of COVID-19 disease, whereas Adenwala et al 26 highlighted a case with nodular episcleritis as the first manifestation of COVID-19. Sanjay et al 27 reported a series of patients who developed episcleritis and scleritis after COVID-19 infection and vaccination. Immune complex deposition in vessels leading to vasculitis of small vessels at the level of the sclera is the proposed mechanism for scleritis in this scenario.…”

Section: Ocular Surface Manifestations Of Coronavirus Disease 2019mentioning

confidence: 99%

“…Immune complex deposition in vessels leading to vasculitis of small vessels at the level of the sclera is the proposed mechanism for scleritis in this scenario. Dysregulation of the immune system has also been proposed as a mechanism of scleritis after COVID-19 disease 27 …”

Section: Ocular Surface Manifestations Of Coronavirus Disease 2019mentioning

confidence: 99%

“…Eighteen cases of scleritis and episcleritis were reported in the literature. Of these, Sanjay et al 27 described 8 cases of scleritis and 7 cases of episcleritis after vaccinations of AZD1222 and BBV152, 9 of which were recurrences. The average onset time was 16 days (ranged = 4–30).…”

Section: Ocular Surface Adverse Reactions To Coronavirus Disease 2019...mentioning

confidence: 99%

“…Clinical presentation usually occurs as anterior scleritis and either diffuse or nodular episcleritis (n = 12). Most described cases were mild and successfully resolved within 1 month after standard conventional treatment 27 …”

Section: Ocular Surface Adverse Reactions To Coronavirus Disease 2019...mentioning

confidence: 99%

“…Dysregulation of the immune system has also been proposed as a mechanism of scleritis after COVID-19 disease. 27…”

Section: Scleritismentioning

confidence: 99%

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Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

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The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 was one of the most devastating public health issues in recent decades. The ophthalmology community is as concerned about the COVID-19 pandemic as the global public health community is, as COVID-19 was recognized to affect multiple organs in the human body, including the eyes, early in the course of the outbreak. Ophthalmic manifestations of COVID-19 are highly variable and could range from mild ocular surface abnormalities to potentially sight and life-threatening orbital and neuro-ophthalmic diseases. Furthermore, ophthalmic manifestations may also be the presenting or the only findings in COVID-19 infections. Meanwhile, global vaccination campaigns to attain herd immunity in different populations are the major strategy to mitigate the pandemic. As novel vaccinations against COVID-19 emerged, so were reports on adverse ophthalmic reactions potentially related to such. As the world enters a post-pandemic state where COVID-19 continues to exist and evolve as an endemic globally, the ophthalmology community ought to be aware of and keep abreast of the latest knowledge of ophthalmic associations with COVID-19 and its vaccinations. This review is a summary of the latest literature on the ophthalmic manifestations of COVID-19 and the adverse ophthalmic reactions related to its vaccinations.

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Section: Ocular Surface Manifestations Of Coronavirus Disease 2019mentioning

confidence: 99%

Section: Ocular Surface Manifestations Of Coronavirus Disease 2019mentioning

confidence: 99%

Section: Ocular Surface Adverse Reactions To Coronavirus Disease 2019...mentioning

confidence: 99%

Section: Ocular Surface Adverse Reactions To Coronavirus Disease 2019...mentioning

confidence: 99%

“…Dysregulation of the immune system has also been proposed as a mechanism of scleritis after COVID-19 disease. 27…”

Section: Scleritismentioning

confidence: 99%

See 3 more Smart Citations

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Lin,

Sen,

Gupta

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Management of Scleritis in Older Adults

Butler,

Tomkins-Netzer,

Reiser

et al. 2024

Drugs Aging

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Scleritis, an inflammatory disease of the eye affecting scleral tissue, presents unique challenges in the older adult population. Unlike their younger counterparts, older individuals manifest a distinct spectrum of the disease with different underlying etiologies, co-morbidities, altered immune function, and an increased risk of systemic side effects from medication choices. Addressing these complexities necessitates a comprehensive and multidisciplinary approach. Treatment of choice will depend on any underlying cause but generally involves non-steroidal anti-inflammatory drugs, systemic or local corticosteroids, and potentially disease-modifying anti-rheumatic drugs. Utilization of these therapeutic agents in older adults warrants careful consideration because of their potential side-effect profiles. This article critically examines the specific concerns for the use of these drugs in older patients and reviews the existing literature on their use in this specific cohort.

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Azd-1222/bbv-152

2023

Reactions Weekly

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Scleritis and Episcleritis following Coronavirus Disease (COVID-19) Vaccination

Cited by 4 publications

References 41 publications

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Update on coronavirus disease 2019: Ophthalmic Manifestations and Adverse Reactions to Vaccination

Management of Scleritis in Older Adults

Azd-1222/bbv-152

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