Abstract:Scleredema of Buschke (SB) is a rare disorder of connective tissue characterized by diffuse non-pitting induration of the skin, mainly on the cervical, deltoid and dorsal regions. It is a cutaneous mucinosis of unknown etiology and is associated with bacterial or viral infections, hematological disorders and diabetes mellitus. Histopathological examination shows thickened dermis with wide collagen bundles separated by gaps that correspond to mucopolysaccharide deposits, visualized using special staining. Sever… Show more
“…Treatment of skin changes caused by collagen degradation in the SAB is complicated except the type-1 in which scleroderma is reversed spontaneously within years (2). Skin hardening and tightening is progressive in type-2 and type-3 SAB: There are many modalities tried in treatment SAB such as phototherapy, cortico steroids, methotrexate with some success (3)(4)(5). Pentoxifylline is a phosphodiesterase four inhibitor molecule which has antifibrotic action through inhibition of collagen synthesis.…”
This is an Open Access Article distributed under the terms of Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any area, original work is properly cited.
“…Treatment of skin changes caused by collagen degradation in the SAB is complicated except the type-1 in which scleroderma is reversed spontaneously within years (2). Skin hardening and tightening is progressive in type-2 and type-3 SAB: There are many modalities tried in treatment SAB such as phototherapy, cortico steroids, methotrexate with some success (3)(4)(5). Pentoxifylline is a phosphodiesterase four inhibitor molecule which has antifibrotic action through inhibition of collagen synthesis.…”
This is an Open Access Article distributed under the terms of Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any area, original work is properly cited.
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