Scleredema adultorum associated with type 2 diabetes mellitus: a report of three cases

Lewerenz, V.; Ruzícka, T.

doi:10.1111/j.1468-3083.2006.01959.x

Cited by 22 publications

(12 citation statements)

References 8 publications

(9 reference statements)

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“…The histology is characterized by enlarged collagen bundles separated by spaces of mucin deposits which results in a thickening of the dermis. The epidermis remains unaffected 76,78 . Treatment is often difficult.…”

Section: Various Skin Signsmentioning

confidence: 99%

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Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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Diabetes mellitus is the most common endocrine disorder with continuously increasing prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both an enormous financial burden and a reduced quality of life of the affected patients. Long-standing diabetes may impair skin homeostasis resulting in skin manifestations in at least one third of all diabetics. The skin involvement may be the first presenting sign of diabetes, thus the respective skin signs should lead to diabetes focused diagnostic. Besides, the skin signs may be considered as a marker for the course of the disease or for the success of therapeutic interventions.

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Section: Various Skin Signsmentioning

confidence: 99%

“…The epidermis remains unaffected. 76,78 Treatment is often difficult. Physiotherapy, high-dose penicillin and phototherapy (bath-PUVA, UVA1) can be beneficial in scleredema adultorum.…”

Section: Scleredema Adultorum Of Buschkementioning

confidence: 99%

Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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“…Die Erkrankung kann zu starken Bewegungsbeeinträchti-gungen führen und sich im Verlauf über Gesicht, Arme und -seltener -über die Beine unter Aussparung der Hände und der Füße ausbreiten [1]. Sollte der ganze Rumpf betroffen sein, kann oft eine restriktive Lungenerkrankung komplizierend auftreten [1,5]. Beteiligungen von weiteren Organen und Geweben wie Zunge, Herz, Skelett-und Augenmuskulatur, Ösophagus, Leber, Perikard, Pleura und Speicheldrüsen wurden beschrieben [6].…”

Section: Diskussionunclassified

“…Darüber hinaus finden sich in der Literatur 2 Berichte über erfolgreiche Behandlungen mit dem selektiven Östrogenrezeptor-modulator Tamoxifen [1] sowie Berichte über eine wirksame PUVA-Therapie. Im Jahr 2004 erschien der erste Bericht über eine erfolgreiche Therapie mit Low-dose-UV-A1 (340-400 nm) sowie später auch mit High-dose-UV-A1 bei Patienten mit Scleroedema adultorum [3,5]. In weiteren Publikationen wurden eine signifikante Reduktion der Dicke der Dermis sowie eine deutliche Verbesserung der Gelenkbeweglichkeit unter UV-A1-Therapie beschrieben [4].…”

Section: Diskussionunclassified

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Scleroedema diabeticorum

et al. 2011

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Scleredema adultorum is characterized by induration of the skin on the neck, shoulders and upper back caused by increased accumulation of collagen and aminoglycans in the dermis. The induration may progress and lead to pronounced restriction of mobility. Scleredema diabeticorum is one type of scleredema adultorum associated with diabetes mellitus. Multiple therapies have been tried, but most of them have not proven to be consistently effective. We report two cases of scleredema diabeticorum treated successfully with UVA-1- as well as physiotherapy and topical corticosteroids; this approach led to improvement in skin changes and mobility.

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Cutaneous Mucinoses

Rongioletti

2016

Rook's Textbook of Dermatology, Ninth Edition

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The cutaneous mucinoses are a heterogeneous group of disorders whose main characteristic is abnormal mucin deposition in the skin. The aetiopathogenesis of cutaneous mucinoses is unknown, although cytokines such as tumour necrosis factor α and β, interleukin 1, interleukin 6 and transforming growth factor β and/or polyclonal and monoclonal immunoglobulins and other unidentified factors in the serum of affected patients may induce up‐regulation of glycosaminoglycan synthesis. The cutaneous mucinoses are divided into two categories: (i) primary cutaneous mucinoses in which the mucin deposit is the main histological feature resulting in clinically distinctive lesions; and (ii) secondary mucinoses in which the mucin deposition is only an additional histological epiphenomenon. Primary mucinoses can be divided into dermal and follicular mucinoses. The former includes lichen myxoedematosus, reticular erythematous mucinosis, scleroedema, mucinoses in thyroid disease, papular and nodular mucinosis in connective tissue diseases, self‐healing juvenile cutaneous mucinosis, cutaneous focal mucinosis, digital myxoid cyst; the latter include Pinkus follicular mucinosis and urticaria‐like follicular mucinosis. Associated disorders include paraproteinaemia (scleromyxoedema, scleroedema), diabetes mellitus (scleroedema), hyperthyroidism (pretibial myxoedema), hypothyroidism (generalized myxoedema) and lupus erythematosus, dermatomyositis or scleroderma (papular and nodular mucinosis in connective tissue diseases).

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Scleredema adultorum associated with type 2 diabetes mellitus: a report of three cases

Cited by 22 publications

References 8 publications

Skin signs in diabetes mellitus

Skin signs in diabetes mellitus

Scleroedema diabeticorum

Cutaneous Mucinoses

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