Scleredema: A review of thirty-three cases

Treatment of Scleredema Diabeticorum with Tamoxifen: Figure 1.

“…Scleredema is frequently mistaken for systemic sclerosis (SSc), although the distribution and pattern of skin involvement in these 2 distinct clinical entities are quite different 4 . The hands and feet are usually spared, in contrast to SSc.…”

Scleredema of Buschke Successfully Treated With Electron Beam Therapy

“…3,4 The link between these 2 conditions is unclear, but it is known that diabetic patients with scleredema usually have difficulty controlling their diabetes, as well as diabetic complications. 5 Scleredema produces findings that include a nonpitting hardening of the skin around the neck, shoulders, and trunk. This induration may be preceded by a transient erythematous eruption, as occurred in our patient.…”

Scleredema Adultorum of Buschke Treated With Radiation

“…Three variants are recognized: the first is accompanied by an acute febrile illness and characterized by resolution over several months; the second follows a slow progressive course with no apparent underlying disease; and the third is associated with diabetes mellitus. This third type tends to persist and is reported by some authors 1 to be related to glucose control and by others 2 to be unrelated. Multiple treatment modalities for scleredema have been published as case reports or small series, including bath psoralen UV-A, 3 cyclosporine, 4 low-dose methotrexate, 5 extracorporeal photopheresis, 6 and high-dose penicillin.…”