Sclera as the Target Tissue in Progressive Myopia

Iomdina, Elena N.; Тарутта, Е. П.; Markossian, Gajane; Aksenova, Julia; Смирнова, Т. С.; Bedretdinov, A. N.

doi:10.21164/pomjlifesci.69

Cited by 11 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presented results confirm that the sclera may indeed be of fundamental importance in myopia progression. [3][4][5] This may be visualized by considering the emmetropic sclera as a half-inflated balloon. When not fully inflated certain shape irregularities may still be seen in the balloon surface.…”

Section: Discussionmentioning

confidence: 99%

“…20 Similarly, a recent work on schoolage children with progressive myopia reported biomechanical abnormalities of the corneo-scleral area. 4 As the sclera affects the restraint or facilitation of eye growth, different myopia control strategies have been proposed based on strengthening the sclera, such as scleral reinforcement and collagen cross-linking. 3 However, most current techniques for myopia control are highly invasive and show a variable outcome between patients.…”

Section: Discussionmentioning

confidence: 99%

“…Some of these methods focus on the sclera, a tissue that expands excessively during myopia progression. 3,4 The sclera is a though, fibrous, viscoelastic tissue whose biomechanical characteristics help determine the ocular size and the shape. Consequently, it plays a major role in determining the refractive state of the eye.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

In vivo anterior scleral morphometry, axial length and myopia

Consejo

Rozema

2020

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

Purpose: To in-vivo quantify differences in anterior scleral shape between myopes and emmetropes and relate them with axial length and refractive power.Methods: Forty-two participants (84 eyes) were included in this study. Twenty-five participants were categorised as emmetropes and seventeen participants were categorised as myopes. The refractive state was measured monocularly using a closed window autorefractometer. Axial length was acquired using an optical biometer and topographical data was obtained using a non-contact corneo-scleral topographer. Anterior scleral asymmetry was calculated from 3-dimensional data using a custom-made algorithm and further correlated to axial length and refractive power. Right and left eyes were analysed independently.Results: The anterior scleral shape was highly correlated with axial length (OS and OD: R = 0.76, p<0.001) and moderately correlated with refractive power (OS: R = 0.48, OD: R = 0.53, both p < 0.01). The more myopic the eye, the less asymmetric the anterior sclera.Conclusions: Both axial length and refractive power are highly correlated with the anterior scleral shape. The refractive state of each patient should therefore be taken into consideration when analysing scleral shape when planning certain treatments or surgeries and when fitting scleral contact lenses.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In vivo anterior scleral morphometry, axial length and myopia

Consejo

Rozema

2020

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

show abstract

“…Studies show that an increased level of cortisol inhibits collagen synthesis in connective tissues and isolated fibroblasts ( 65 ). Shifts in hormone levels cause deregulation between matrix metalloproteinases and tissue inhibitors of metalloproteinases (TIMs), which disrupt cross linking of fibrils and fibers and reduce the transverse crosslinking of the collagen network in the sclera ( 66 ), leading to sclera degradation [ Figure 2A(c )].…”

Section: Factors Involved In Myopia Digital Therapeuticsmentioning

confidence: 99%

Digital Therapeutics: Exploring the Possibilities of Digital Intervention for Myopia

Lee¹,

Choi²,

Hahm³

et al. 2021

Front. Digit. Health

View full text Add to dashboard Cite

Pediatric myopia is increasing globally and has become a major public health issue. However, the mechanism of pediatric myopia is still poorly understood, and there is no effective treatment to prevent its progression. Based on results from animal and clinical studies, certain neuronal–humoral factors (NHFs), such as IGF-1, dopamine, and cortisol may be involved in the progression of pediatric myopia. Digital therapeutics uses evidence-based software as therapeutic interventions and it has the potential to offer innovative treatment strategies for pediatric myopia beyond conventional treatment methods. In this perspective article, we introduce digital therapeutics SAT-001, a software algorithm that modulates the level of NHFs to reduce the progression of pediatric myopia. The proposed mechanism is based on a theoretical hypothesis derived from scientific research and clinical studies and will be further confirmed by evidence generated from clinical studies involving pediatric myopia.

show abstract

“…The major manifestations of CM include increased joint mobility, softness of joint capsules and ligaments (Iomdina et al, 2015). Other symptoms including ease of dislocations and joint sprains, muscle and joint pain, hyperelastic skin, vision disorders, disorders of the gut, problems with body stabilization and other Brighton criteria indicate the presence of BHJS.…”

Section: Introductionmentioning

confidence: 99%

The Assessment of the Occurrence of Benign Hypermobility Joint Syndrome in Physiotherapy Students

Żyżniewska-Banaszak

Tchórzewska-Korba

Gębska

et al. 2017

Central European Journal of Sport Sciences and Medicine

View full text Add to dashboard Cite

The occurrence of connective tissue disorders is an important factor for development of occupational diseases in professions requiring a non-ergonomic and often static load of the musculoskeletal system. Symptoms of the connective tissue disorders appear at different ages. The diagnosis of hypermobility is an important problem due to the lack of uniform diagnostic criteria. The aim of this paper is to evaluate the incidence of joint hypermobility and its relation with a history of injuries and the level of physical activity in Physiotherapy students. The study involved 143 students (69% female, 31% male) aged 18 to 27 years (M = 20.7; SD = 1.43). The assessment of the occurrence of Benign Hypermobility Joint Syndrome (BHJS) syndrome was performed using the Beighton and Brighton scale. Among the surveyed students almost 82% of the women and just over 18% of the men fulfilled the diagnostic criteria for the diagnosis of hypermobility. A significant difference was also observed in the physical activity of the students. Among those who showed no signs of hypermobility exactly half of the participants trained sports as amateurs, while in the group of people with hypermobility the proportion was lower by nearly half. BHJS was not related to injuries and operations in the study group.

show abstract

Sclera as the Target Tissue in Progressive Myopia

Cited by 11 publications

References 9 publications

In vivo anterior scleral morphometry, axial length and myopia

In vivo anterior scleral morphometry, axial length and myopia

Digital Therapeutics: Exploring the Possibilities of Digital Intervention for Myopia

The Assessment of the Occurrence of Benign Hypermobility Joint Syndrome in Physiotherapy Students

Contact Info

Product

Resources

About