Scintimammography with Tc-99m MIBI in patients with suspicion of primary breast cancer

Palmedo, Holger; Schomburg, A.; Grünwald, Frank; Mallmann, Peter; Boldt, I; Biersack, H.-J.

doi:10.1016/0969-8051(96)00084-4

Cited by 20 publications

(15 citation statements)

References 7 publications

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“…Specificity in these two groups was clearly over 70%. These values are slightly below those reported by previous studies [23][24][25][26][27][28][29][30]. Generally, it can be expected that it will be more difficult to obtain similar results if the method is assessed by a blinded multicentre study.…”

Section: Histopathologycontrasting

confidence: 54%

“…Recent studies using 99m Tc-MIBI for breast cancer detection have shown high sensitivity and specificity for palpable cancers [22][23][24][25][26][27][28][29][30][31][32]. For non-palpable breast lesions, diagnostic accuracy has been less favorable [25,27,29,30]. In this trial, scintigraphy with 99m Tc-MIBI read blinded achieved an overall sensitivity of 71%.…”

Section: Histopathologymentioning

confidence: 99%

“…Disease with a high inflammatory component might yield false-positive results, most likely due to increased local perfusion. Areas with increased mitochondrial activity and density, such as juvenile adenomas and hyperproliferative disease, can also cause false-positive MIBI uptake [22,25,27,29]. However, patients with atypical hyperproliferative disease have a higher relative risk for breast cancer [52].…”

Section: Histopathologymentioning

confidence: 99%

“…The accumulation of 99m Tc-MIBI in the tumour is dependent on the quantity of mitochondria in the tumour cell, on the electric membrane potential and on the expression of the multidrug resistance (MDR) gene [42][43][44][45][46]. Recent studies using 99m Tc-MIBI for breast cancer detection have shown high sensitivity and specificity for palpable cancers [22][23][24][25][26][27][28][29][30][31][32]. For non-palpable breast lesions, diagnostic accuracy has been less favorable [25,27,29,30].…”

Section: Histopathologymentioning

confidence: 99%

“…A number of studies have demonstrated high diagnostic accuracy of 99m Tc-MIBI for the detection of breast cancer [22][23][24][25][26][27][28][29][30][31][32]. Therefore, this multicentre trial was set up to confirm the value of scintimammography using 99m Tc-MIBI.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Palmedo

Biersack

Lastoria³

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

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108

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Abstract. The aim of the trial was to determine the diagnostic accuracy of scintimmammography with technetium-99m methoxyisobutylisonitrile ( 99m Tc-MIBI) in the detection of primary breast cancer and to verify its clinical usefulness. A total of 246 patients with a suspicious breast mass or positive mammogram were included in this prospective European multicentre trial. At 5 min and 60 min (optional) p.i. two lateral prone images were acquired for 10 min each; 30 min p.i. one anterior image was acquired for 10 min. There were 253 lesions (195 palpable and 58 non-palpable), in respect of which histology revealed 165 cancers and 88 benign lesions. Institutional and blinded read results were correlated to core laboratory histopathology results obtained during excisional biopsy. Diagnostic accuracy for the detection of breast cancer was calculated per lesion. The overall sensitivity and specificity of blinded read scintimammography were 71% and 69%, respectively. For palpable lesions, the sensitivity of blinded read and institutional read scintimammography was 83% and 91%, respectively. Sensitivity was not dependent on the density of the breast tissue. Invasive ductal and invasive lobular cancers showed similar sensitivity. The sensitivity and specificity of mammography were 91% and 42%, respectively, and did not depend on the tumour size. In 60% of false-negative mammograms, 99m Tc-MIBI was able to diagnose malignancy (true-positive). High-quality imaging with 99m Tc-MIBI has a high diagnostic accuracy for the detection of primary breast cancer. Used as a complementary method, scintimammography with 99m Tc-MIBI can help to diagnose breast cancer at an earlier stage in patients with dense breasts.

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Section: Histopathologycontrasting

confidence: 54%

Section: Histopathologymentioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Palmedo

Biersack

Lastoria³

et al. 1998

European Journal of Nuclear Medicine and Molecular Imaging

Self Cite

108

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Oncology

Elgazzar¹,

Sarıkaya²

2018

Nuclear Medicine Companion

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99mTc-Sestamibi Scintimammography

Bucerius

2011

99mTc-Sestamibi

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From an anatomical point of view, the mammary gland is part of the female secondary sexual characteristics. The primary biological function of the mammary glands is the feeding of infants with breast milk. The mammary glands belong to the major glands of the cutis (glandulae cutis) and develop from epithelial cones, which grow in the surrounding connective tissue. Initially, the mammary glands are established in the same way in both genders.The female mammary glands are located on the major and minor pectoral muscles (M. pectoralis major, M. pectoralis minor) between the third and the seventh rib and between the sternal-and axillary line. The arterial blood supply of the mammary glands is provided by vascular branches (R. mammarii mediales and laterales) of the internal and lateral thoracic arteries (A. thoracica interna, A. thoracica lateralis) as well as by branches (R. preforantes and R. mammarii laterales) of the anterior and posterior intercostal arteries (Aa. intercostales anterior and posterior). The venous drain follows from superficial veins into the lateral and internal thoracic veins (Vv. thoracica lateralis and interna). The mammary glands are characterized by numerous lymphatic vessels, which build a superficial and deep lymphatic mesh with several directions of lymphatic drainage. From a clinical point of view, the main and most important lymphatic drainage reaches the axillary lymph nodes. Additional lymphatic drains flow off to the cervical lymph nodes superior to the clavicles and via the interpectoral lymphatic nodes (N. lymphatici interpectorales) between the pectoral muscles to the axillary lymph nodes, via the parasternal lymph nodes (N. lymphatici parasternales) along the internal thorac vein, and via the

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Scintimammography with Tc-99m MIBI in patients with suspicion of primary breast cancer

Cited by 20 publications

References 7 publications

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Scintimammography with technetium-99m methoxyisobutylisonitrile: results of a prospective European multicentre trial

Oncology

99mTc-Sestamibi Scintimammography

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