Abstract. We present a preliminary design for a neutron detection system that is compact, lightweight, and low power consuming, utilizing the CubeSat platform making it suitable for space-based applications. This is made possible using the scintillating crystal lithium indium diselenide ( 6 LiInSe 2 ), the first crystal to include 6 Li in the crystalline structure, and a silicon avalanche photodiode. The schematics of this instrument are presented as well as the response of the instrument to initial testing under alpha radiation. A principal aim of this work is to demonstrate the feasibility of such a neutron detection system within a CubeSat platform. The entire end-to-end system presented here is 10 × 10 × 15 cm 3 , weighs 670 g, and requires 5 V direct current at 3 W.