Scintigraphy of Benign Bone Disease

Abstract

Bone scintigraphy is ideally suited for the investigation of benign bone disease as it functions at a physiological level. It is freely available and has whole-body capability and high-contrast resolution. When coupled with single-photon emission computed tomography/computed tomography (SPECT/CT), it can be utilized to provide precise anatomical localization, attenuation correction, and therefore better lesion localization. A considerable volume of data has accumulated on the role of bone scintigraphy in trauma and its complications, overuse injuries, vascular disease of bone, metabolic bone diseases, and a variety of other disorders. This article is an overview of the established applications and signposts of potential future applications with the increasing prevalence of SPECT/CT devices and technical advances in attenuation correction, collimator modeling, and resolution recovery software.

Risonanza magnetica whole-body per l’identificazione delle metastasi scheletriche: confronto con la scintigrafia ossea

“…BS is sensitive for detecting bone metastases, but supplemental imaging studies are needed to define unclear findings, as BS has limited specificity [3,4].…”

“…La BS è una metodica sensibile per la diagnosi di metastasi ossee ma non altamente specifica e pertanto necessita di integrazioni diagnostiche per chiarire risultati equivoci [3,4].…”

Pediatric Bone Scintigraphy Update

“…Even though it is rare for the bone scan to be the first study in a child with trauma, there are some instances where bone scintigraphy may be helpful in revealing injury that is not defined by conventional radiographs. 3 This is particularly helpful in non-verbal neurodevelopmentally delayed children who are not able to verbalize and localize the site of pain. The bone scan provides a total body screen that is sensitive to detect the site of bone or soft tissue abnormality and then often the addition of SPECT/CT can provide accurate diagnosis ( Figs.…”

“…There have been several excellent reviews of bone scintigraphy since pediatric bone update was reported in this journal in 2007. [1][2][3][4] This current update is to identify some of the differences in evaluating the skeletal system in children and to highlight how hybrid imaging has been incorporated into the evaluation to diagnose musculoskeletal disorders in children.…”

Emerging Applications of an Experimental Single Photon Emission Computed Tomography: An Analysis of 16 Areas of Interest in the Pig’s Model

“…Single photon emission computed tomography (SPECT) is an imaging technique that refines planar imaging and permits a more precise quantization of images acquired by common tomographic techniques by removing the focus from regions not of clinical interest. Single photon emission computed tomography is well established and has found successful clinical application for the study of many organ systems, including the skeletal system (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11).…”