Scintigraphic Findings in Renal Malakoplakia

Cox, Joseph E.; Cowan, Robert J.

doi:10.1097/00003072-199506000-00005

Cited by 9 publications

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“…2 Recently, medical treatment with antimicrobial agents capable of intracellular penetration, such as trimethoprimsulfamethoxazole, ciprofloxacin, and rifampin, has been successfully used. 9,12,13 During the follow-up evaluation in the present case, an initial increase in the number of lesions prompted a change in the antibiotic treatment. Cholinergic agents and ascorbic acid have been used as adjuvant therapy because of their ability to enhance leukocyte function; however, their role is still controversial.…”

Section: Discussionmentioning

confidence: 76%

“…The etiology of the disorder is not known, although an immunologic defect has been proposed as a cause. [2][3][4][5][9][10][11][12][13][14] We re-port a case of bilateral renal malacoplakia in which the kidney lesion on 1 side was managed conservatively and monitored using sonography. Nephrectomy was performed in most cases in the past 2 ; medical management has been successful in more recent cases.…”

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confidence: 99%

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Sonographic findings in renal parenchymal malacoplakia

Venkatesh

Mehrotra

Gujral

2000

J. Clin. Ultrasound

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Malacoplakia of the kidney is a rare inflammatory disorder. We describe a case of bilateral renal malacoplakia in which the patient had diffuse involvement of the left kidney and a focal lesion in the right kidney. Sonography showed a diffusely echogenic, enlarged left kidney with loss of corticomedullary differentiation and a single anechoic lesion measuring 1.8 × 1.6 × 1.3 cm in the right kidney. A left nephrectomy was performed, and the right kidney was managed conservatively with sonographic monitoring. © 2000 John Wiley & Sons, Inc. J Clin Ultrasound 28:353–357, 2000.

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Section: Discussionmentioning

confidence: 76%

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confidence: 99%

Sonographic findings in renal parenchymal malacoplakia

Venkatesh

Mehrotra

Gujral

2000

J. Clin. Ultrasound

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“…In contrast to gallium scanning, known to show enhanced uptake in malakoplakia (8,9), there is no experience with FDG-PET in malakoplakia: to our knowledge this is the fi rst report describing FDG uptake in malakoplakia. FDG-PET is known to be an important diagnostic tool in malignant (10), infectious (11) and infl ammatory diseases (12) and poorly defi ned entities such as fever of unknown origin (13,14).…”

Section: -Fluoro-deoxyglucose Positron Emission Tomography May Contmentioning

confidence: 84%

“…months to three years) than the group that was treated with other antibiotics (survival[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Optimal treatment duration is not known and duration ranges from 4 to 9 months.…”

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confidence: 99%

18-Fluoro-Deoxyglucose Positron Emission Tomography May Contribute to the Diagnosis and Follow-Up of Malakoplakia

Vanbrabant

Drieskens

Blockmans

2004

Acta Clinica Belgica

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Malakoplakia is a rare inflammatory disease involving most frequently the urinary tract. We present a case of bilateral renal malakoplakia, in which FDG-PET contributed to diagnosis. We made this diagnosis on the basis of clinical presentation, renal biopsy showing a mixed cellular infiltrate with granuloma formation and possible Michaelis-Gutmann bodies, resolution of the lesions after prolonged antibiotic therapy and evidence of leukocyte dysfunction. We briefly discuss the pathophysiology and therapy of this rare and difficult to prove disease and the role of FDG-PET in the diagnosis of inflammatory and infectious diseases.

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“…3,[6][7][8] Sonography, CT, and gallium scanning have also been used for follow-up evaluations. [2][3][4][5][9][10][11][12][13][14] We re-port a case of bilateral renal malacoplakia in which the kidney lesion on 1 side was managed conservatively and monitored using sonography.…”

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confidence: 99%

Sonographic findings in renal parenchymal malacoplakia

Venkatesh¹,

Mehrotra²,

Gujral³

2000

J. Clin. Ultrasound

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ABSTRACT:Malacoplakia of the kidney is a rare inflammatory disorder. We describe a case of bilateral renal malacoplakia in which the patient had diffuse involvement of the left kidney and a focal lesion in the right kidney. Sonography showed a diffusely echogenic, enlarged left kidney with loss of corticomedullary differentiation and a single anechoic lesion measuring 1.8 × 1.6 × 1.3 cm in the right kidney. A left nephrectomy was performed, and the right kidney was managed conservatively with sonographic moni- Keywords: malacoplakia, renal; ultrasonography R enal parenchymal malacoplakia is an uncommon inflammatory disorder; bilateral involvement is rare. Renal parenchymal malacoplakia is usually diagnosed by histopathology, which shows the characteristic Michaelis-Gutmann (MG) bodies and von Hansemann cells. The etiology of the disorder is not known, although an immunologic defect has been proposed as a cause. Clinically, patients with renal parenchymal malacoplakia present most commonly with fever and less frequently with a mass. Nephrectomy was performed in most cases in the past 2 ; medical management has been successful in more recent cases. [2][3][4][5] Various parameters, such as the level of clinical improvement, results of urinalysis and urine culture, and serum creatinine levels, have been used to assess therapeutic responses. 3,[6][7][8] Sonography, CT, and gallium scanning have also been used for follow-up evaluations.2-5,9-14 We report a case of bilateral renal malacoplakia in which the kidney lesion on 1 side was managed conservatively and monitored using sonography. CASE REPORTA 26-year-old woman presented with fever, chills, and left flank pain that had been present for 2 months. She also complained of anorexia and a 10-kg weight loss in the past month. The patient had no history of dysuria, diabetes, folliculitis, or abscesses, but she had been treated for pulmonary tuberculosis 20 years previously. The patient had fever (temperature, 38.3°C) with pallor and no icterus. There was a smooth, firm, mobile, tender lump in the left flank region suggestive of an enlarged left kidney. The remainder of the clinical examination was unremarkable. The results of serologic and human immunodeficiency virus tests were negative. A chest x-ray showed a fibrotic lesion in the left midzone suggestive of an old tubercular lesion. Results of laboratory studies showed: hemoglobin level, 6 g/dl; white blood cell count, 13,400 white blood cells/l with 65% polymorphs and 35% lymphocytes; erythrocyte sedimentation rate, 14 mm/hour; serum creatinine level, 1.6 mg/dl; and urine albumin level, 30 mg/dl. Microscopy showed few pus cells. Sonography, performed with an RT 3200 Advantage II ultrasound scanner (GE Medical Systems, Milwaukee, WI) and a 3.5-MHz convexarray transducer, showed a diffusely echogenic, enlarged left kidney with loss of corticomedullary differentiation ( Figure 1A) and a single anechoic lesion measuring 1.8 × 1.6 × 1.3 cm in the right kidney. Contrast-enhanced CT demonstrated a grossly enlarged, nonfunct...

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Scintigraphic Findings in Renal Malakoplakia

Cited by 9 publications

References 0 publications

Sonographic findings in renal parenchymal malacoplakia

Sonographic findings in renal parenchymal malacoplakia

18-Fluoro-Deoxyglucose Positron Emission Tomography May Contribute to the Diagnosis and Follow-Up of Malakoplakia

Sonographic findings in renal parenchymal malacoplakia

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