Scintigraphic detection of acute gastrointestinal bleeding using 99Tcm-DTPA

Hm, Abdel-Dayem; Ziada, G.; Owunwanne, Azu; Mahajan, Kamlesh; Erickson, S J; Elwan, Mohammed Samir Mokhtar Hamed

doi:10.1097/00006231-198410000-00005

Cited by 4 publications

(1 citation statement)

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“…Many radiopharmaceuticals are currently being used to detect and localize gastrointestinal (GI) bleeding sites. Among these are " m Tc-DTPA (1,4), " m Tc-RBCs (5), " m Tc-sulphur colloid (2) and 9 9 m Tc0 4 (3). An adequate animal model for studying various factors which affect the detection and localization of the bleeding site has not been developed.…”

Section: Introductionmentioning

confidence: 99%

Development of an Animal Model Using a Closed System to Study the Sensitivity of a Radiopharmaceutical for the Detection of Gastrointestinal Bleeding

Mahajan¹,

Abdel‐Dayem²,

Ericksson³

et al. 1987

Nuklearmedizin

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An experimental animal model using a closed system to study the sensitivity of radiopharmaceuticals for the detection and localization of gastrointestinal (Gl) bleeding site in a sheep was developed. This model was validated with 99mTc-DTPA. Radioactivity as low as 85.47 ± 13.32 kBq in a volume of 2.1 ±0.14 ml at a bleeding rate of 0.07 ml/min was detected. Simulated intermittent bleeding experiments indicated that at 1 h after injection of 99mTc-DTPA there was still enough circulating radioactivity to bleed into the gut and that it was possible to perform repeat injection of 99mTc-DTPA as early as 2 h after the first injection.

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Section: Introductionmentioning

confidence: 99%

Development of an Animal Model Using a Closed System to Study the Sensitivity of a Radiopharmaceutical for the Detection of Gastrointestinal Bleeding

Mahajan¹,

Abdel‐Dayem²,

Ericksson³

et al. 1987

Nuklearmedizin

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Localization of lower gastrointestinal bleeding using in vivo technetium-99m-labelled red blood cell scintigraphy

Nicholson

Neoptolemos

Sharp

et al. 1989

Journal of British Surgery

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Technetium-99m-labelled red blood cell scintigraphy was used in the investigation of 41 patients with major rectal haemorrhage. Red cells were labelled in vivo with technetium-99m pertechnetate and serial scans (0-36 h) were taken using a large field gamma camera. Twenty-two men and 15 women, mean age 71.3 years (range 32-91 years), and four children were studied. Forty-three scans were performed in all and there were 31 positive and 12 negative results. In each case the accuracy of the scan in localizing the bleeding site was checked either by independent investigations or at laparotomy. A definite bleeding site was identified in 30 cases and red cell scintigraphy correctly localized 29 of these (sensitivity 97 per cent). In the remaining 13 cases a bleeding site was not identified by any of the independent investigations and in this group there were two false positive scans (specificity 85 per cent). The investigation had a high predictive value when both positive (94 per cent) and negative (92 per cent). These data suggest that technetium-99m-labelled red cell scintigraphy should be used more widely in the investigation of patients with suspected lower gastrointestinal haemorrhage.

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The gastrointestinal tract

Croft¹,

Williams²

1991

Clinical Nuclear Medicine

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Scintigraphic detection of acute gastrointestinal bleeding using 99Tcm-DTPA

Cited by 4 publications

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Development of an Animal Model Using a Closed System to Study the Sensitivity of a Radiopharmaceutical for the Detection of Gastrointestinal Bleeding

Development of an Animal Model Using a Closed System to Study the Sensitivity of a Radiopharmaceutical for the Detection of Gastrointestinal Bleeding

Localization of lower gastrointestinal bleeding using in vivo technetium-99m-labelled red blood cell scintigraphy

The gastrointestinal tract

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