Scintigraphic Assessment of Normal Biliary Physiology.

Williams, Walter H.; Brar, H.; Bobba, V. R.; Krishnamurthy, Gerbail T.

doi:10.1097/00003072-198309009-00043

Cited by 5 publications

(8 citation statements)

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“…This study showed that late biliary-to-bowel transit time was not significant in diagnosing CAC. The reported values of late biliary-to-bowel transit time in healthy volunteers were close to the value we reported (range, 7-30%) [22,24,25].…”

Section: Discussionsupporting

confidence: 89%

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Diagnostic value of gallbladder emptying variables in chronic acalculous cholecystitis as assessed by fatty meal cholescintigraphy

Al-Muqbel

2009

Nuclear Medicine Communications

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Section: Discussionsupporting

confidence: 89%

“…Three studies investigated this variable in healthy volunteers and reported mean values similar to our mean value in both volunteer and patient groups [14,22,23]. This study showed that late biliary-to-bowel transit time was not significant in diagnosing CAC.…”

Section: Discussionsupporting

confidence: 73%

Diagnostic value of gallbladder emptying variables in chronic acalculous cholecystitis as assessed by fatty meal cholescintigraphy

Al-Muqbel

2009

Nuclear Medicine Communications

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“…Following intravenous injection of the radiopharmaceutical, the CBD is normally seen by 20 min, a similar excretion time to that seen with biliary iodinated and MR biliary contrast agents [15,16]. Both the gallbladder and the small intestine are seen within 30 min in the great majority of patients [19]. Cholecystectomy is followed by significantly earlier visualization of the lower part of the CBD and of the duodenum [20].…”

Section: Discussionmentioning

confidence: 99%

“…In nonobstructed post-cholecystectomy patients, the contrast material enters the duodenum in less than 25 min [19,20]. Any delay of contrast passage through the ampulla indicates functional or anatomical abnormalities [19,20].…”

Section: Discussionmentioning

confidence: 99%

Complementary role of helical CT cholangiography to MR cholangiography in the evaluation of biliary function and kinetics

Eracleous¹,

Genagritis²,

Papanikolaou

et al. 2005

Eur Radiol

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To explore the potential role of computed tomographic cholangiography (CTC) in relation to magnetic resonance cholangiography (MRC) in cases in which knowledge of biliary kinetics and functional information are important for therapeutic decisions, 31 patients (14 men and 17 women) underwent MRC followed by CTC. We examined nine post-cholecystectomy cases with right upper quadrant abdominal pain, six cases with a previous biliary-enteric anastomosis and clinical evidence of cholangitis, eight biliary strictures with pain or symptoms of cholangitis, four cases with strong clinical evidence of sclerosing cholangitis, three cases with suspected post-laparoscopic cholecystectomy bile leakage, and one case with chronic pancreatitis and a common bile duct stent associated with cholangitis. In relation to MRC, CTC provided additional biliary functional information as follows: abnormal biliary drainage through the ampulla in 7/9 cholecystectomy cases, impaired drainage in 3/6 biliary-enteric anastomoses, and complete obstruction in 2/8 biliary strictures. CTC diagnosed early sclerosing cholangitis in 4/4 cases and confirmed suspected bile leakage in 1/3 post-laparoscopic cholecystectomy patients, and the patency of the biliary stent in the patient with chronic pancreatitis. Thus, CTC provides clinically important information about the function and kinetics of bile and complements findings obtained by MRC.

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“…Biliary duct retention and delayed biliary-to-bowel transit at 60 min is seen in up to 20% of healthy subjects, supposedly due to a hypertonic sphincter of Oddi (67). A functional delay in biliary-to-bowel transit also occurs in up to 50% of patients who are administered sincalide to empty the gallbladder before cholescintigraphy (68).…”

Section: Partialmentioning

confidence: 99%

Hepatobiliary Scintigraphy in 2014

Ziessman

2014

J Nucl Med

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CE Credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than December 2017. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 80% of the questions correctly to receive 1.0 CEH (Continuing Education Hour) credit. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test. Participants who have already taken the exam using JNM and passed cannot retake the exam.Cholescintigraphy with 99m Tc-hepatobiliary radiopharmaceuticals has been an important, clinically useful diagnostic imaging study for almost 4 decades. It continues to be in much clinical demand; however, the indications, methodology, and interpretative criteria have evolved over the years. This review will emphasize state-of-the-art methodology and diagnostic criteria for various clinical indications, including acute cholecystitis, chronic acalculous gallbladder disease, high-grade and partial biliary obstruction, and the postcholecystectomy pain syndrome, including sphincter-of-Oddi dysfunction and biliary atresia. The review will also emphasize the use of diagnostic pharmacologic interventions, particularly sincalide. Now almost 4 decades old, 99m Tc cholescintigraphy continues to be a radionuclide imaging study in much clinical demand. Its strength lies in the fact that the diagnostic information provided defines pathophysiology rather than anatomy.123 I-and 123 I-rose bengal were the first clinically useful cholescintigraphic agents; however, image quality was relatively poor (Fig. 1). 99m Tc-hepatobiliary radiopharmaceuticals began to be widely used by the early 1980s.The discovery of 99m Tc-hepatobiliary (HIDA) radiopharmaceuticals was by chance. During investigation for a cardiac imaging radiopharmaceutical, it was found that 99m Tclabeled lidocaine was not a good cardiac imaging agent but cleared through the hepatobiliary system. With chemical modification, 99m Tc-HIDA imaging agents were born. Loberg et al. reported on this in 1976 (1). Its structure is simply that of 2 lidocaine analogs bichelated to 99m Tc by iminodiacetic acid (IDA) (Fig. 2). HIDA (hepatoiminodiacetic acid) has long been used as a generic term for cholescintigraphy.Modifications of the benzene ring of the lidocaine analogs resulted in an alphabet soup of hepatobiliary radiopharmaceuticals (PIPIDA, BIDA, EIDA, DIDA, DISIDA, etc.), each with different rates of hepatic uptake and clearance. The first 99m Tc-HIDA radiopharmaceutical was approved for clinical use by the Food and Drug Administration in 1982. Dimethyl IDA (lidofenin [Technescan; Mallinckrodt]) was a major advance, but image quality and diagnostic utility were suboptimal in patients with seru...

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Scintigraphic Assessment of Normal Biliary Physiology.

Cited by 5 publications

References 0 publications

Diagnostic value of gallbladder emptying variables in chronic acalculous cholecystitis as assessed by fatty meal cholescintigraphy

Diagnostic value of gallbladder emptying variables in chronic acalculous cholecystitis as assessed by fatty meal cholescintigraphy

Complementary role of helical CT cholangiography to MR cholangiography in the evaluation of biliary function and kinetics

Hepatobiliary Scintigraphy in 2014

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