Scientist, doctor, teacher: on the 80th anniversary of Professor Yakov Maksimovich Vakhrushev

Хохлачева, Н. А.; Михайлова, О. Д.; Горбунов, А. Ю.

doi:10.31146/1682-8658-ecg-181-9-94-96

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Удельный вес желчи (УВж) оценивали по ареометру для урины (АУ) (Украина), уровень кислотности (рНж) -используя зонд с сурьмяным и хлорсеребряным электродами оригинальной конструкции. Метод кристаллографии использован при изучении морфологической характеристики пузырной порции желчи [18].…”

Section: материалы и методыunclassified

“…Кристаллография желчи позволила нам оценить её пространственные надмолекулярные структуры, выявить изменения структуры желчи, в отличие от количественного и качественного анализа, проведенного с помощью биохимических и физических методов [18,20,21].…”

Section: результатыunclassified

See 1 more Smart Citation

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Vakhrushev,

Kosareva,

Suchkova

et al. 2024

ECG

View full text Add to dashboard Cite

The purpose of the work is to diagnose the early stage of cholelithiasis through a comprehensive study of bile in patients with NAFLD. Materials and methods. We examined 210 patients with NAFLD at the steatosis stage. The diagnosis was confirmed based on general clinical indicators, ultrasound and liver elastography data, and assessment of blood enzyme levels. All patients underwent ultrasound examination of the gallbladder, study of the microscopic and physicochemical properties of bile (specific gravity, acidity, surface tension, viscosity, lithogenicity indices, cholesterol content, bile acids, phospholipids) obtained as a result of multifractional duodenal intubation, and crystallography. Results: Ultrasound examination revealed biliary sludge in 72% of patients. Microscopic examination of bile revealed crystals of cholesterol and calcium bilirubinate in 75.4% of patients. Biochemical analysis of bile revealed significant changes, expressed in increased cholesterol, decreased bile acids, phospholipids, cholate-cholesterol and phospholipid-cholesterol ratios. A study of the physical properties revealed thickening of bile and an increase in its viscosity. Crystallography revealed elements with high optical activity, which became the basis for the formation of gallstones. Conclusions: In patients in the steatosis stage of NAFLD, a decrease in lithogenicity indices, an increase in acidity and thickening of bile are determined, indicating the tendency of bile to stone formation. Signs of biliary sludge (putty-like bile, microlithiasis), characteristic of stage I cholelithiasis, are detected by ultrasound of the gallbladder in 72% of patients in the steatosis stage of NAFLD. Bile crystallography made it possible to identify crystal optical markers indicating changes in the microstructure of gallbladder bile in patients in the steatosis stage of NAFLD. When conducting an examination of patients with NAFLD in the steatosis stage, to diagnose the early stage of cholelithiasis, it is recommended to conduct multifractional duodenal intubation with subsequent study of the physicochemical properties and structural changes of bile.

show abstract

Section: материалы и методыunclassified

Section: результатыunclassified

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Vakhrushev,

Kosareva,

Suchkova

et al. 2024

ECG

View full text Add to dashboard Cite

show abstract

“…It is believed that drinking hard water is not harmful to human health [3,4], but there is evidence of negative health effects of both hard drinking water [3][4][5][6][7][8][9][10] and soft drinking water [11][12][13][14][15]. Therefore, water hardness is an important indicator of water quality for water use conditions [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Comparison of hardness of drinking water and morbidity of population consuming water from infiltration water intake

Yalaletdinova,

Malkova,

Kantor

2024

E3S Web Conf.

View full text Add to dashboard Cite

The link between the total hardness of drinking water and the primary and total population turnover in polyclinics of the city, located on the territory supplied with drinking water from the infiltration water intake, for some diseases (malignant neoplasms, blood diseases, endocrine diseases, diseases of the circulatory system, respiratory diseases, digestive diseases, skin diseases, diseases of the musculoskeletal apparatus, diseases of the genitourinary system, congenital deformities) was searched. Different manifestations of links between diseases of the population and the available level of water hardness of the infiltration water intake zone were revealed.

show abstract

Scientist, doctor, teacher: on the 80th anniversary of Professor Yakov Maksimovich Vakhrushev

Abstract: The article describes the life, scientific and professional path of a doctor of medical sciences, professor, honored doctor of the Urals and the Russian Federation Y. M. Vakhrushev

Cited by 2 publications

References 0 publications

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Biochemical and structural changes in bile in non-alcoholic fatty liver disease

Comparison of hardness of drinking water and morbidity of population consuming water from infiltration water intake

Contact Info

Product

Resources

About