The objective of this study is to detect the FTIR fingerprints of phytocompounds in the plant Spermacoce hispida L. The FTIR analysis of methanol leaf extract of plant Spermacoce hispida L. revealed the presence of 19 bioactive phytocompounds such as aliphatic primary amine, alkene, alkanes, amine salt, aldehydes, aromatic compound, α, β-unsaturated ester, conjugated alkene, nitro compound, sulfonyl chloride, phenol, aromatic amine, alkyl aryl ether, vinyl ether, ester, tertiary alcohol, primary alcohol, carboxylic acids and halo compound.