Some of the most persistently recurring research questions in the fields of personality and social psychology concern sex differences. Although much progress has been made, no research has addressed the basic question of whether there is one general construct of genderedness that runs through various life domains, or whether genderedness is specific to certain domains. In order to determine whether being gender typical in one way goes together with being gender typical also in other ways, we investigated whether 16-year old girls and boys (N = 4106) finishing Finnish elementary school differ in their personality traits, values, cognitive abilities, academic achievement, and educational track. To do this, we updated the gender diagnosticity approach by employing penalized logistic regression to estimate multivariate sex differences based on both binary and continuous variables. The preregistered analysis show that the magnitude of sex differences varies a lot from domain to domain, that narrow measures, such as grade profiles, can be highly accurate in predicting sex, whereas broad measures, such as general cognitive ability, can be useless, and that the correlations between femininity-masculinity scores based on different domains, despite all being positive, are too weak to suggest the existence of a general factor of genderedness. Our more exploratory analyses show that more focus on gender typicality could offer important insights into the role of gender in shaping people’s lives. We discuss how future research could employ the methods we introduce to further our understanding of sex differences and gender typicality in developmental and educational fields.