Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa

Madikizela, Balungile; McGaw, Lyndy Joy

doi:10.1016/j.jep.2018.06.002

Cited by 14 publications

(15 citation statements)

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“…Royle Phyllanthaceae Snowberry tree, white-berry bush (English), witbessiebos (Afrikaans), isibangamhlota sehlati, umyaweyane (Zulu) Leaf, root, bark and fruit extracts M. tuberculosis MIC = 312 μg/mL Dzoyem et al (2016) Galenia africana L. Aizoaceae Yellow bush (English), brakkraalbossie, geelbos, kraalbos, muisbos, muisgeelbossie, perdebos (Afrikaans), iqina (Xhosa) Bark extracts M. tuberculosis MIC = 1200 μg/mL (bark and roots) Mativandlela et al (2008) M. smegmatis (model for TB) MIC = 780 μg/mL (roots) Gerrardina foliosa Oliv. Gerrardinaceae Krantz-berry (English), Umaluleka (Zulu), Umlulama (Zulu) Aqueous bark extracts M. tuberculosis MIC = 310 μg/mL Madikizela, and McGaw (2018) Gunnera perpensa L. Gunneraceae Wild rhubarb, river pumpkin (English), wilde ramenas, ravierpampoen (Afrikaans), qobo (Sotho), rambola-vhadzimu (Venda), iphuzi, ighobo (Xhosa), ugobhe (Zulu) Root extracts M. tuberculosis Inactive Lall and Meyer (1999) Helichrysum kraussii Sch.Bip. Asteraceae Straw everlasting (English), sewejaartjie (Afrikaans), isipheshane, isiqoqo (Zulu) Leaf and stem extracts M. smegmatis (model for TB) MIC = 2000 μg/mL York et al (2011) K. pneumoniae MIC = 1330 μg/mL Helichrysum melanacme DC.…”

Section: Resultsmentioning

confidence: 99%

“…& Zeyh. Apiaceae Acetone, ethanol and aqueous leaf extracts M. tuberculosis MIC = 80–5000 μg/mL Madikizela, and McGaw (2018) Heteropogon contortus (L.) P.Beauv. ex Roem.…”

Section: Resultsmentioning

confidence: 99%

“… Hypericaceae Unknown Leaf extracts K. pneumoniae MIC = 160 μg/mL Elisha et al (2017) Hypoxis spp. Hypoxidaceae Yellow stars, star lily, african potato (English), sterretjie, Afrika-patat (Afrikaans), inkomfe, ilabatheka (Zulu) Root extracts M. smegmatis (model for TB) MIC = 5330 μg/mL York et al (2011) K. pneumoniae MIC = 1670 μg/mL Hypoxis colchicifolia Baker Bulb acetone and ethanol extracts M. tuberculosis MIC = 160–630 μg/mL Madikizela, and McGaw (2018) Bark, acetone, aqueous and ethanol extracts MIC = 1250–2500 μg/mL Indigofera arrecta A.Rich. Fabaceae African indigo (English) Leaf and root extracts M. arum (model for tuberculosis) MIC = 780 μg/mL (leafs) Madikizela et al (2013) K. pneumoniae MIC = 390 μg/mL (roots) Kigelia africana (Lam.)…”

Section: Resultsmentioning

confidence: 99%

“… Geraniaceae Vine-leaved pelargonium, balm-scented pelargonium (English) Aerial parts extracts K. pneumoniae MIC = 4000 μg/mL Lalli et al (2008) Phymaspermum acerosum (DC.) Källersjö Asteraceae Geelblombos (Afrikaans), isibhaha-segceke, umhlonishwa (Zulu) Acetone, ethanol and aqueous leaf extracts M. tuberculosis MIC = 80–630 μg/mL Madikizela, and McGaw (2018) Acetone, ethanol and aqueous root extracts MIC = 40–310 μg/mL Piper capense L.f. Piperaceae Wild pepper (English) Root acetone extract M. tuberculosis MIC = −100 μg/mL Green et al (2010) Pittosporum viridiflorum Sims Pittosporaceae Cheesewood, white cape beech (English), kasuur, witboekenhout (Afrikaans), umVusamvu, Umkhwenkwe, Umphushane (Zulu), kgalagangwe (Sotho), mosetlela (Southern Sotho), mulondwane, mutanzwakhamelo (Venda), umgqwengqwe (Xhosa) Leaf extracts K. pneumoniae MIC = 160 μg/mL Elisha et al (2017) M. tuberculosis MIC = −310-2500 μg/mL Madikizela, and McGaw (2018) Plectranthus neochilus Schltr. Lamiaceae Smelly spur flower, lobster flower (English), rotstuinsalie (Afrikaans) Leaf extracts M. smegmatis (model for TB) MIC = 1000 μg/mL York et al (2011) K. pneumoniae MIC = 1330 μg/mL Podocarpus elongatus (Aiton) L'Hér.…”

Section: Resultsmentioning

confidence: 99%

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The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Cock

Vuuren

2020

Journal of Ethnopharmacology

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Ethnopharmacological relevance Multiple plant species were used traditionally in southern Africa to treat bacterial respiratory diseases. This review summarises this usage and highlights plant species that are yet to be verified for these activities. Aim of the study This manuscript reviews the traditional usage of southern African plant species to treat bacterial respiratory diseases with the aim of highlighting gaps in the literature and focusing future studies. Materials and methods An extensive review of ethnobotanical books, reviews and primary scientific studies was undertaken to identify southern African plants which are used in traditional southern African medicine to treat bacterial respiratory diseases. We also searched for southern African plants whose inhibitory activity against bacterial respiratory pathogens has been conmfirmed, to highlight gaps in the literature and focus future studies. Results One hundred and eighty-seven southern African plant species are recorded as traditional therapies for bacterial respiratory infections. Scientific evaluations of 178 plant species were recorded, although only 42 of these were selected for screening on the basis of their ethnobotanical uses. Therefore, the potential of 146 species used teraditionally to treat bacterial respiratory diseases are yet to be verified. Conclusions The inhibitory properties of southern African medicinal plants against bacterial respiratory pathogens is relatively poorly explored and the antibacterial activity of most plant species remains to be verified.

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Section: Resultsmentioning

confidence: 99%

“…& Zeyh. Apiaceae Acetone, ethanol and aqueous leaf extracts M. tuberculosis MIC = 80–5000 μg/mL Madikizela, and McGaw (2018) Heteropogon contortus (L.) P.Beauv. ex Roem.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Cock

Vuuren

2020

Journal of Ethnopharmacology

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“…Madikizela and McGaw [75] evaluated the genotoxicity activities of aqueous, acetone, and ethanol leaf extracts of H. arborescens against Salmonella typhimurium TA98 and TA100. The ethanol extracts showed clear mutagenicity against TA100 with numbers of revertant colonies greater than twice that of the negative controls for the 5 mg/ml, the highest concentration tested, however, decreasing with decreasing concentrations of extracts [75].…”

Section: Genotoxicity Activitiesmentioning

confidence: 99%

Heteromorpha Arborescens: A Review of Its Botany, Medicinal Uses, and Pharmacological Properties

Maroyi

2018

Asian J Pharm Clin Res

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Heteromorpha arborescens is an important medicinal plant species throughout its distributional range in tropical Africa. This study evaluated the botany, medicinal uses, and pharmacological activities of H. arborescens. Literature focusing on the botany, phytochemical, pharmacological, and toxicological properties of H. arborescens were obtained from scientific databases such as SCOPUS, Science Direct, PubMed, SciFinder, Medline, and Google Scholar. Pre-electronic literature sources such as book chapters, books, journal articles, conference papers, and other scientific documents were obtained from the University library. Literature search revealed that H. arborescens is used as an aphrodisiac, as herbal medicine for shortness of breath, intestinal worms, inflammation, pain, respiratory problems, skin infections, headache, fever, and malaria. Pharmacological studies of compounds and H. arborescens extracts revealed anthelmintic, antiarthritic, antibacterial, antifungal, anti-inflammatory, antimycobacterial, antinociceptive, antioxidant, antipeptic ulcer, anti-scabies, antispasmodic, antiviral, cytotoxicity, genotoxicity, and uterotonic activities. More detailed research is needed aimed at assessing phytochemical, pharmacological, and toxicological properties of different plant parts and phytochemical compounds isolated from the species.

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Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones

et al. 2021

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Abstract8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2′-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen Mycobacterium tuberculosis. Synthesis, structural characterization and in vitro testing against Mycobacterium aurum DSM 43999 and M. tuberculosis H37Rv of halogenated 2-(4-ethoxycarbonylpiperazin-1-yl)-1,3-benzothiazin-4-ones lacking a nitro group are reported. X-ray crystallography reveals that the structure of the BTZ scaffold can significantly deviate from planarity. In contrast to recent reports, the results of the present study indicate that further investigation of halogenated non-nitro BTZs for antitubercular activity is less than a promising approach.

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Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa

Abstract: The results indicate that Heteromorpha trifoliata and Phymaspermum acerosum should be investigated further for antimycobacterial efficacy against drug resistant strains of Mycobacterium.

Cited by 14 publications

References 57 publications

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

The traditional use of southern African medicinal plants for the treatment of bacterial respiratory diseases: A review of the ethnobotany and scientific evaluations

Heteromorpha Arborescens: A Review of Its Botany, Medicinal Uses, and Pharmacological Properties

Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones

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