Scientific publishing during the COVID-19 pandemic

Kummer, Rüdiger von

doi:10.1007/s00234-020-02608-4

Cited by 2 publications

(6 citation statements)

References 4 publications

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“…Throughout this study, arterial partial pressure of carbon dioxide, assessed as part of NASA's standard measures, showed a small but significant increase during the HDBR+CO 2 phase (McGregor et al, 2021 ), though see also (Laurie et al, 2020b ; Laurie, Macias, et al, 2019 ). Cerebral perfusion was also assessed during our MRI sessions using arterial spin labeling (Roberts et al, 2021 ). As reported by Roberts et al, both subgroups showed a reduction in average perfusion across the whole brain during the HDBR+CO 2 phase relative to baseline measures (Roberts et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Cerebral perfusion was also assessed during our MRI sessions using arterial spin labeling (Roberts et al, 2021 ). As reported by Roberts et al, both subgroups showed a reduction in average perfusion across the whole brain during the HDBR+CO 2 phase relative to baseline measures (Roberts et al, 2021 ). On HDT7, the SANS subgroup exhibited a greater reduction in perfusion compared to the NoSANS subgroup.…”

Section: Discussionmentioning

confidence: 99%

“…On HDT29, average cerebral perfusion of the SANS group exhibited partial recovery towards baseline levels whereas cerebral perfusion of the NoSANS subgroup remained consistent through the HDBR+CO 2 phase. Perfusion values for both subgroups gradually returned towards baseline levels during the recovery phase, but remained 3% below baseline levels on R + 12 (Roberts et al, 2021 ). These cerebral perfusion results point to subgroup differences in vasoreactivity and autoregulatory responses during the HDBR+CO 2 intervention.…”

Section: Discussionmentioning

confidence: 99%

“…Subgroup differences in cerebral perfusion changes during the intervention may contribute to the longitudinal pattern FC changes presented here. However, drawing parallels between perfusion changes and regional FC changes during HDBR+CO 2 is not clear as perfusion was assessed at the average across the entire brain (Roberts et al, 2021 ). To address this issue, a follow‐up investigation should assess cerebral perfusion changes within the regions constituting the FC networks identified in the current study.…”

Section: Discussionmentioning

confidence: 99%

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Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

McGregor

Lee

Mulder

et al. 2021

Human Brain Mapping

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Following long‐duration spaceflight, some astronauts exhibit ophthalmic structural changes referred to as Spaceflight Associated Neuro‐ocular Syndrome (SANS). Optic disc edema is a common sign of SANS. The origin and effects of SANS are not understood as signs of SANS have not manifested in previous spaceflight analog studies. In the current spaceflight analog study, 11 subjects underwent 30 days of strict head down‐tilt bed rest in elevated ambient carbon dioxide (HDBR+CO2). Using functional magnetic resonance imaging (fMRI), we acquired resting‐state fMRI data at 6 time points: before (2), during (2), and after (2) the HDBR+CO2 intervention. Five participants developed optic disc edema during the intervention (SANS subgroup) and 6 did not (NoSANS group). This occurrence allowed us to explore whether development of signs of SANS during the spaceflight analog impacted resting‐state functional connectivity during HDBR+CO2. In light of previous work identifying genetic and biochemical predictors of SANS, we further assessed whether the SANS and NoSANS subgroups exhibited differential patterns of resting‐state functional connectivity prior to the HDBR+CO2 intervention. We found that the SANS and NoSANS subgroups exhibited distinct patterns of resting‐state functional connectivity changes during HDBR+CO2 within visual and vestibular‐related brain networks. The SANS and NoSANS subgroups also exhibited different resting‐state functional connectivity prior to HDBR+CO2 within a visual cortical network and within a large‐scale network of brain areas involved in multisensory integration. We further present associations between functional connectivity within the identified networks and previously identified genetic and biochemical predictors of SANS. Subgroup differences in resting‐state functional connectivity changes may reflect differential patterns of visual and vestibular reweighting as optic disc edema develops during the spaceflight analog. This finding suggests that SANS impacts not only neuro‐ocular structures, but also functional brain organization. Future prospective investigations incorporating sensory assessments are required to determine the functional significance of the observed connectivity differences.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

McGregor

Lee

Mulder

et al. 2021

Human Brain Mapping

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“…The use of machine learning and radiomics have been suggested for various ap-plications in the imaging and diagnosis of meningiomas with promising outcomes [ 212 ]. Differentiating between meningeal-based and intra-axial lesions using MRI can be challenging in some cases.…”

Section: Selected Examples On Mri Biomarkers In Solid Tumorsmentioning

confidence: 99%

Identification of Tumor-Specific MRI Biomarkers Using Machine Learning (ML)

et al. 2021

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The identification of reliable and non-invasive oncology biomarkers remains a main priority in healthcare. There are only a few biomarkers that have been approved as diagnostic for cancer. The most frequently used cancer biomarkers are derived from either biological materials or imaging data. Most cancer biomarkers suffer from a lack of high specificity. However, the latest advancements in machine learning (ML) and artificial intelligence (AI) have enabled the identification of highly predictive, disease-specific biomarkers. Such biomarkers can be used to diagnose cancer patients, to predict cancer prognosis, or even to predict treatment efficacy. Herein, we provide a summary of the current status of developing and applying Magnetic resonance imaging (MRI) biomarkers in cancer care. We focus on all aspects of MRI biomarkers, starting from MRI data collection, preprocessing and machine learning methods, and ending with summarizing the types of existing biomarkers and their clinical applications in different cancer types.

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Scientific publishing during the COVID-19 pandemic

Cited by 2 publications

References 4 publications

Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

Ophthalmic changes in a spaceflight analog are associated with brain functional reorganization

Identification of Tumor-Specific MRI Biomarkers Using Machine Learning (ML)

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