Scientific Opinion on the substantiation of health claims related to silicon and protection against aluminium accumulation in the brain (ID 290), “cardiovascular health” (ID 289), forming a protective coat on the mucous membrane of the stomach (ID 345), n

Products, Efsa Panel on Dietetic

doi:10.2903/j.efsa.2011.2259

Cited by 28 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…stimulating macrophages and increasing circulating lymphocytes; protection against aluminium accumulation in the brain; 'cardiovascular health'; forming a protective coat on the mucous membrane of the stomach; neutralisation of gastric acid; contribution to normal formation of collagen and connective tissue; maintenance of normal bone; maintenance of normal joints; maintenance of normal appearance and elasticity of the skin; and contribution to normal formation of hair and nails). On the basis of the data presented, the NDA Panel concluded that a cause and effect relationship had not been established between the consumption of silicon and any of the health claims proposed (EFSA NDA Panel, 2009, 2011 (JECFA, 1968(JECFA, , 2002.…”

Section: 3mentioning

confidence: 99%

“…The Panel is aware that the mineral silicon (Si) is included in the positive lists of minerals that can be added to foods, including food supplements, as defined by Annex I to Regulation (EC) No 1925No /2006 address the Terms of Reference of the current mandate and ensure consistency with previous scientific opinions issued on other sources of silicon (EFSA 2009a,b;EFSA ANS Panel, 2016), the Panel considered that bioavailability of OSA from OSA-VC should be the basis for the evaluation of the bioavailability of silicon from that source.…”

Section: Interpretation Of the Terms Of Referencementioning

confidence: 99%

“…The NDA Panel has also evaluated a number of health claims related to silicon pursuant to Article 13(1) of Regulation (EC) No 1924No /2006 5 (i.e. stimulating macrophages and increasing circulating lymphocytes; protection against aluminium accumulation in the brain; 'cardiovascular health'; forming a protective coat on the mucous membrane of the stomach; neutralisation of gastric acid; contribution to normal formation of collagen and connective tissue; maintenance of normal bone; maintenance of normal joints; maintenance of normal appearance and elasticity of the skin; and contribution to normal formation of hair and nails).…”

Section: 3mentioning

confidence: 99%

See 2 more Smart Citations

Safety of orthosilicic acid‐vanillin complex (OSA‐VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source

Younes¹,

Aggett²,

Aguilar³

et al. 2018

EFS2

View full text Add to dashboard Cite

The present scientific opinion deals with the safety of orthosilicic acid‐vanillin complex (OSA‐VC) as a novel food ingredient for use as a source of silicon (Si) in food supplements and with the bioavailability of Si from this source. OSA‐VC is stable in liquid solution at low pH values. OSA from OSA‐VC was available as revealed by the increase in plasma Si concentrations after oral ingestion in human volunteers. The toxicological data provided in support of the current application were not in accordance with the Tier 1 requirement of the ‘Guidance for submission for food additive evaluations’; however, this was considered justified by the Panel given that OSA‐VC at pH 6.8 dissociates into orthosilicic acid and vanillin. The daily consumption of OSA‐VC at the dose recommended by the applicant would provide a supplemental intake of Si of approximately 10–18 mg Si/day which would result in an estimated total intake of roughly 30–70 mg Si/day. The maximum vanillin intake resulting from the consumption of OSA‐VC would be less than 5% of the acceptable daily intake (ADI) value for vanillin of 10 mg/kg body weight (bw) per day established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) in 2002. The Panel concluded that there would be no safety concern with the proposed use and use level of OSA‐VC as a novel food ingredient intended to be used as a source of Si in food supplements for the adult population. The Panel concluded that OSA, measured as Si, is bioavailable following ingestion of OSA‐VC and appears similar to values reported in the literature for other established sources of OSA.

show abstract

Section: 3mentioning

confidence: 99%

Section: Interpretation Of the Terms Of Referencementioning

confidence: 99%

Section: 3mentioning

confidence: 99%

See 1 more Smart Citation

Safety of orthosilicic acid‐vanillin complex (OSA‐VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source

Younes¹,

Aggett²,

Aguilar³

et al. 2018

EFS2

View full text Add to dashboard Cite

show abstract

“…The Panel is aware that the mineral silicon is included in the positive lists of minerals that can be added to foods, including food supplements, as defined by Annex I to Regulation (EC) No 1925No /2006 silicon is typically present in food in the form of orthosilicic acid (OSA) and as such is readily absorbed from the gastrointestinal tract in humans and then readily excreted in urine. Therefore, in order to address the Terms of Reference of the current mandate, and consistently with previous scientific opinions issued on other sources of silicon, the Panel considered bioavailability of OSA from MMST, should be the basis for the evaluation of the bioavailability of silicon from that source.…”

Section: Interpretation Of Terms Of Referencementioning

confidence: 99%

“…The Panel is aware that the mineral silicon is included in the positive lists of minerals that can be added to foods, including food supplements, as defined by Annex I to Regulation (EC) No 1925No /2006 and Annex I to Directive 2002/46/EC, respectively. Data from literature have however established that silicon is typically present in food in the form of orthosilicic acid (OSA) and as such is readily absorbed from the gastrointestinal tract in humans and then readily excreted in urine.…”

Section: Interpretation Of Terms Of Referencementioning

confidence: 99%

Safety of organic silicon (monomethylsilanetriol, MMST) as a novel food ingredient for use as a source of silicon in food supplements and bioavailability of orthosilicic acid from the source

2016

EFS2

View full text Add to dashboard Cite

Following a request from the European Commission, the EFSA Panel on Food Additives and Nutrient Sources added to food (ANS) was asked to deliver an opinion on the safety of organic silicon (monomethylsilanetriol, MMST) as a novel food ingredient for use as a source of silicon in food supplements, and on the bioavailability of silicon from this source. MMST is proposed to be used as an aqueous solution at a concentration of 4.1 mM, corresponding to 115 mg Si/L. The anticipated intake of silicon from the proposed uses and use levels of 60-90 mL/day of MMST solution corresponds to approximately 7-10 mg Si/day. Data from in vitro and in vivo tests showed no genotoxic effect of MMST. From a 90-day toxicity study in rats a no observed adverse effect level (NOAEL) was set at the concentration of 20.5 mM of MMST, corresponding to 232 mg/kg body weight (bw) per day of MMST, the highest dose tested and technically achievable. The Panel considered these data as fulfilling the requirements for the evaluation of the safety of the novel food ingredient and did not request additional testing neither for chronic toxicity and carcinogenicity nor for reprotoxicity and developmental toxicity. The Panel therefore concluded that the proposed use and use levels of MMST as a source of silicon to be used in food supplements is not of safety concern. The conversion of MMST to orthosilicic acid (OSA), the form under which silicon is typically present in food, could not be directly measured, and therefore, the Panel based its opinion on the indirect evidence provided and concluded that OSA is released from MMST and silicon bioavailable from the source. The Panel did not conclude on the safety of MMST in terms of the amount of silicon that may be consumed, as this is outside the remit of the ANS Panel. © European Food Safety Authority, 2016Keywords: organic silicon, monomethylsilanetriol, MMST, nutrient source, novel food ingredient, food supplements

show abstract

Porous Silicon and Functional Foods

Canham

2014

Handbook of Porous Silicon

View full text Add to dashboard Cite

Scientific Opinion on the substantiation of health claims related to silicon and protection against aluminium accumulation in the brain (ID 290), “cardiovascular health” (ID 289), forming a protective coat on the mucous membrane of the stomach (ID 345), n

Cited by 28 publications

References 11 publications

Safety of orthosilicic acid‐vanillin complex (OSA‐VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source

Safety of orthosilicic acid‐vanillin complex (OSA‐VC) as a novel food ingredient to be used in food supplements as a source of silicon and bioavailability of silicon from the source

Safety of organic silicon (monomethylsilanetriol, MMST) as a novel food ingredient for use as a source of silicon in food supplements and bioavailability of orthosilicic acid from the source

Porous Silicon and Functional Foods

Contact Info

Product

Resources

About