Scientific Opinion on the substantiation of health claims related to soy isoflavones and protection of DNA, proteins and lipids from oxidative damage (ID 1286, 4245), maintenance of normal blood LDL cholesterol concentrations (ID 1135, 1704a, 3093a), reduction of vasomotor symptoms associated with menopause (ID 1654, 1704b, 2140, 3093b, 3154, 3590), maintenance of normal skin tonicity (ID 1704a), contribution to normal hair growth (ID 1704a, 4254), “cardiovascular health” (ID 3587), treatment of prostate c

,

doi:10.2903/j.efsa.2011.2264

Cited by 20 publications

(1 citation statement)

References 116 publications

(206 reference statements)

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“…Other widely accepted products by consumers are erectile dysfunction (ED) supplements, which are featured in the online marketplace on pages with claims that they naturally treat ED. However, their efficacy and safety are largely unknown, which limits the ability to counsel patients regarding their use [37]. In a previous study, the authors identified 19 unique ingredients in testosterone-boosting supplements, and the literature review revealed 191 studies involving the 10 most frequent ingredients with different properties and efficacies.…”

Section: The Importance Of Food Safety and Food Quality In The Food Supplement Industrymentioning

confidence: 99%

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Raposo

Saraiva

Ramos

et al. 2021

Biology

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(1) Background: Cardiovascular disease (CVD) is a major public health concern worldwide and a key cause of morbidity and mortality in developed countries. Accumulating evidence shows that several CVD forms are characterized by significant microcirculatory dysfunction, which may both cause and be caused by macrovascular disease, often preceding clinical manifestations by several years. Therefore, interest in exploring food supplements to prevent and restore microcirculation has grown. Given the continuous need to expand the available therapeutic arsenal for CVD, the food supplements market has recently grown and is expected to continue growing. (2) Methods: We provide an authoritative up-to-date comprehensive review of the impact of food supplementation on microcirculation by analyzing the European and American legal food supplements framework and the importance of food safety/food quality in this industry. We review the main literature about food bioactive compounds with a focus on microcirculation and some main food supplements with proven benefits. (3) Results: Despite a lack of scientific evidence, diet and microcirculatory function are clearly connected. The main food supplement examples in the literature with potential beneficial effects on microcirculation are: Ruscus aculeatus, Centella asiatica, Ginkgo biloba, Salvia miltiorrhiza, Crataegus spp., Ginseng, Mangifera indica, Aesculus hipocastanum, Hamamelis virginiana, and Vitis vinifera. (4) Conclusions: Further clinical trials are necessary to better explore the effects of these food supplements, particularly on humans.

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Section: The Importance Of Food Safety and Food Quality In The Food Supplement Industrymentioning

confidence: 99%

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

Raposo

Saraiva

Ramos

et al. 2021

Biology

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The Role of Glycoalkaloids, Lipids, and Proteins in Tissue Inflammation

Sharma¹,

Coniglio²,

Laganà³

2021

SpringerBriefs in Molecular Science

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Risiken und fraglicher Nutzen von Nahrungsergänzungsmitteln mit isolierten Isoflavonen für Frauen in und nach der Menopause

Andres

Lampen

2012

Bundesgesundheitsbl.

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Isolated isoflavones are frequently offered as dietary supplements for the alleviation of peri- and postmenopausal complaints. These mainly soy-based secondary plant compounds are marketed with the claim of having numerous beneficial effects such as protection against breast cancer, osteoporosis, and cardiovascular diseases. Currently, there is no conclusive evidence for most of these health impacts. In addition, there is a controversial ongoing discussion about the safety of these products. After a long-term intake of high isoflavone doses, adverse effects on the breast tissue, the endometrium, and the thyroid, the last one especially under iodine-deficient conditions, cannot be excluded. Owing to their estrogenic effects, isoflavones may promote the growth of estrogen-sensitive malignant cells. The risk assessment of isoflavones is especially focused on peri- and postmenopausal women because they are the target group for dietary supplements based on isolated isoflavones and have, anyway, a higher risk for breast cancer. Since long-term treatment with isolated isoflavones, especially at high doses, is considered critical, we recommend that patients consume isoflavone-based supplements only after advice and under medical supervision.

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Cited by 20 publications

References 116 publications

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

The Role of Food Supplementation in Microcirculation—A Comprehensive Review

The Role of Glycoalkaloids, Lipids, and Proteins in Tissue Inflammation

Risiken und fraglicher Nutzen von Nahrungsergänzungsmitteln mit isolierten Isoflavonen für Frauen in und nach der Menopause

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