Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils

Knutsen, Helle Katrine; Alexander, J. Iwan D.; Barregård, Lars; Bignami, Margherita; Brüschweiler, Beat Johannes; Ceccatelli, Sandra; Cottrill, Bruce; Dinovi, Michael; Edler, Lutz; Högstrand, Christer; Hoogenboom, L.A.P.; Nebbia, Carlo; Oswald, Isabelle P.; Petersen, Annette; Rose, Martin; Roudot, Alain‐Claude; Schwerdtle, Tanja; Vollmer, Günter; Wallace, Heather M.; Grasl‐Kraupp, Bettina; Grob, Konrad; Penninks, André; Binaglia, Marco; Torres, Ruth Roldán; Vleminckx, Christiane

doi:10.2903/j.efsa.2017.4656

Cited by 2 publications

(2 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the years 2009-2016, the CONTAM Panel evaluated the acceptability of the substances listed in the Annex to Commission Directive 96/3/EC as a acceptable previous cargoes for edible fats and oils, based on its review of the criteria set by SCF (EFSA CONTAM Panel, 2009) and the experience gained in its subsequent evaluations, which highlighted the importance of addressing impurities that might be present (EFSA CONTAM Panel, 2011, 2012a,b, 2017.…”

Section: Methodologiesmentioning

confidence: 99%

“…No new information has been retrieved or provided that would change the previous conclusions of the CONTAM Panel (EFSA CONTAM Panel, 2017) in relation to other substances accepted as previous cargoes, except for calcium lignosulfonate. Therefore, the present opinion of the CONTAM Panel should comprise the re-evaluation of the substance calcium lignosulfonate (CAS No 8061-52-7) following the additional information and data provided to EFSA.…”

Section: Interpretation Of the Terms Of Referencementioning

confidence: 99%

See 1 more Smart Citation

Evaluation of calcium lignosulfonate as a acceptable previous cargo for edible fats and oils

Schrenk¹,

Bignami²,

Bodin³

et al. 2019

EFS2

Self Cite

View full text Add to dashboard Cite

Shipping of edible fats and oils into Europe is permitted in bulk tanks, provided that the previous cargo is included in a positive list. The European Commission requested EFSA to evaluate the acceptability of calcium lignosulfonate as previous cargo for fats and oils. The evaluation was based on the same criteria as those used for the evaluation of the substances currently on the list in the Annex to Commission Directive 96/3/EC as a acceptable previous cargoes for edible fats and oils. In 2017, the EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) concluded that calcium lignosulfonate did not meet the acceptability criteria, due to uncertainties as regards the composition and toxicity of its low-molecular weight fraction (LMWF) below 1,000 Da. In the current evaluation, new information, showing lack of genotoxicity of the LMWF isolated from a technical grade of calcium lignosulfonate was provided. Due to uncertainties regarding the presence of lignosulfonate components below 200 Da in this LMWF tested for genotoxicity, the CONTAM Panel concluded that the information provided was insufficient to assess the acceptability of calcium lignosulfonate as previous cargo. The Panel recommends a better analysis of the LMWF and a new genotoxicity test using this LMWF, including components < 200 Da, and evidence that the tested material is representative of the LMWF in products intended to be shipped as previous cargo for edible fat and oils.

show abstract

Section: Methodologiesmentioning

confidence: 99%

Section: Interpretation Of the Terms Of Referencementioning

confidence: 99%

Evaluation of calcium lignosulfonate as a acceptable previous cargo for edible fats and oils

Schrenk¹,

Bignami²,

Bodin³

et al. 2019

EFS2

Self Cite

View full text Add to dashboard Cite

show abstract

The influence of high and low doses of acrylamide on porcine erythropoiesis

Snarska

Palus

Wysocka

et al. 2020

Journal of Veterinary Research

View full text Add to dashboard Cite

IntroductionDue to the widespread occurrence of acrylamide in the environment, its likely carcinogen status, and the suitability of the pig model as a human analogue, the authors decided to evaluate the impact of high and low doses of this compound on the processes of erythropoiesis in swine bone marrow.Material and MethodsThe experiment was carried out on Danish Landrace pigs at the age of eight weeks and body weight about 20 kg. The animals were divided into three equal groups consisting of five pigs in each. Control animals received empty gelatin capsules (placebos). Animals from the first experimental group received a low dose of acrylamide of 0.5 μg/kg b.w./day (> 99% purity; Sigma-Aldrich, Poland), and animals from the second experimental group received a dose 10 times higher. Placebos and acrylamide capsules were administered with feed every morning for 28 days. After anaesthetisation of the animals, bone marrow from the femur was collected into tubes without an anticoagulant on days 0 and 28. After drying and staining, bone marrow smears were subjected to detailed cytological evaluation using a light microscope.ResultsThis study showed that high and low doses of acrylamide affected the process of porcine erythropoiesis. The cytotoxic effect of acrylamide on this process was demonstrated in a change of the polychromatic erythroblasts/normochromatic erythroblasts ratio.ConclusionBoth doses of acrylamide caused a decrease in the number of ortho- and polychromatic erythroblasts.

show abstract

Scientific opinion on the evaluation of substances as acceptable previous cargoes for edible fats and oils

Cited by 2 publications

References 82 publications

Evaluation of calcium lignosulfonate as a acceptable previous cargo for edible fats and oils

Evaluation of calcium lignosulfonate as a acceptable previous cargo for edible fats and oils

The influence of high and low doses of acrylamide on porcine erythropoiesis

Contact Info

Product

Resources

About