This article reports on a content analysis of science coverage by the leading Italian newspaper, Il Corriere della Sera, over a period of fifty years. Results show an expansion of such coverage over time, although it was increasingly “institutionalized” in new sections devoted to science and medicine. The typical science story can be described as dealing with biomedical issues, referring to a geographical context outside Italy, relying on uncontested scientific expertise and presenting the consequences of science activity in a positive fashion. However, deeper analysis suggests the presence of a marked dualism between two distinct journalistic genres: (1) “science-popularization,” which is characteristic of special sections, overwhelmingly dominated by biomedical topics, depicting science as straightforward, consensual, and bringing improvement to people's lives; and (2) “science as news,” dealing more frequently with other fields such as the physical sciences, paying closer attention to controversy and to the harmful consequences of scientific enterprise. A comparison with similar studies in other countries is also presented.