Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis

Huang, Jinke; Zhang, Jiaqi; Wang, Yifan; Ma, Jing; Yang, Xuefei; Guo, Xiaoxue; Lv, Mi; Ma, Jinxin; Zheng, Yijun; Wang, Fengyun; Tang, Xudong

doi:10.1155/2022/7942845

Cited by 17 publications

(20 citation statements)

References 21 publications

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“…23 -36 However, not all SR/MAs were reported according to PRISMA standards or had the assessment of evidence quality by GRADE. 37,38 In such cases, an overview of SRs/MAs is preferable to the large number of SRs/MAs of lower quality and with less convincing conclusions. 39,40 In addition, an overview can provide limitations that are worth noting and need improvement to drive future high-quality SRs/MAs.…”

Section: Discussionmentioning

confidence: 99%

An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of Acupuncture for Cancer Pain

Zhang,

Ji,

et al. 2023

Integr Cancer Ther

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Background: Systematic reviews (SRs) and meta-analyses (MAs) for the use of acupuncture for cancer pain have been increasing, but the evidence has not been systematically and comprehensively assessed. We aimed to perform an overview of the evidence quality of SRs/MAs of acupuncture for improving cancer pain. Methods: 8 databases were systematically searched to identify SRs/MAs of acupuncture for improving cancer pain. The A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2), Risk of Bias in Systematic Reviews (ROBIS), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Grades of Recommendations, Assessment, Development, and Evaluation (GRADE), respectively, were applied by 2 independent reviewers to evaluate the methodological quality, risk of bias, reporting quality, and evidence quality. Results: A total of 14 SRs/MAs were included in the present study. By AMSTAR-2, two reviews were rated as having high methodological quality, while 12 were given a critically low rating. All SRs/MAs in Phase 1, Domain 1, and Domain 4, according to ROBIS, were at low risk. Furthermore, 4 reviews in Domain 2, twelve reviews in Domain 3, and ten SRs/MAs in Phase 3, were rated as having low risk of bias. With reporting quality, some reporting flaws were identified in the topic of protocol and registration, additional analyses, and search strategy. According to GRADE, the level of evidence quality was “critically low” to “moderate,” and risk of bias was the most common downgraded factor. Conclusion: Acupuncture may be beneficial in improving cancer pain. However, due to the identified limitations and inconsistent findings, we recommend further rigorous, and more standardized SRs/MAs to provide strong evidence for definitive conclusions.

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Section: Discussionmentioning

confidence: 99%

An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of Acupuncture for Cancer Pain

Zhang,

Ji,

et al. 2023

Integr Cancer Ther

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“…Finally, we discussed the evidence of TCM alleviates UC by regulating macrophage polarization and the potential mechanism of TCM regulating macrophage polarization in the treatment of UC. patterns of UC patients were large intestine dampness-heat, followed by spleen-kidney yang deficiency, liver depression and spleen deficiency, spleen-stomach weakness, and spleen deficiency with dampness accumulation, which reflected the progress of UC with different phases (Zhang X. et al, 2022). For UC patients with CM pattern of Large intestine dampnessheat, which clear heat and dampness, harmony qi and blood are needed; For UC patients with CM pattern of Spleen-kidney yang deficiency, which warm and tonify spleen and kidney are needed; For UC patients with CM pattern of liver depression and spleen deficiency, which sooth liver and strengthen spleen are needed; For UC patients with CM pattern of spleenstomach weakness, which tonify the spleen and stomach are needed; For UC patients with CM pattern of Spleen deficiency with dampness accumulation, which tonify spleen and resolve dampness are needed (Zhang X. et al, 2022).…”

Section: Introductionmentioning

confidence: 94%

“…Gegen Qinlian decoction, a classic TCM compound, encompasses Radix Puerariae , Scutellariae , Coptidis Rhizom a, and Licorice . Recent research showed that Gegen Qinlian decoction combined with CWM seemed to be more effective in UC than CWM treatment alone ( Huang et al, 2022 ). A systematic review of randomized controlled trials including 2028 UC patients showed consistent results that Gegen Qinlian decoction treatment alone or Gegen Qinlian decoction combined with CWM treatment had potential benefits in curing UC ( Fan Y. et al, 2019 ).…”

Section: Tcm Alleviates Uc By Regulating Macrophage Polarizationmentioning

confidence: 99%

“…We collected and summarized the research in this area, as shown in Table 1. Baitouweng decoction is the most commonly used TCM formula in the clinical treatment of UC, followed by Shenling Baizhu San (Zhang X. et al, 2022). Baitouweng decoction is consist of Pulsatilla chinensis (Bunge) Regel., Radix, Phellodendron chinense C.K.…”

Section: Tcm Compound Alleviates Uc By Regulating Macrophage Polariza...mentioning

confidence: 99%

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A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization

et al. 2022

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Intestinal macrophages are the main participants of intestinal immune homeostasis and intestinal inflammation. Under different environmental stimuli, intestinal macrophages can be polarized into classical activated pro-inflammatory phenotype (M1) and alternative activated anti-inflammatory phenotype (M2). Its different polarization state is the “guide” to promoting the development and regression of inflammation. Under normal circumstances, intestinal macrophages can protect the intestine from inflammatory damage. However, under the influence of some genetic and environmental factors, the polarization imbalance of intestinal M1/M2 macrophages will lead to the imbalance in the regulation of intestinal inflammation and transform the physiological inflammatory response into pathological intestinal injury. In UC patients, the disorder of intestinal inflammation is closely related to the imbalance of intestinal M1/M2 macrophage polarization. Therefore, restoring the balance of M1/M2 macrophage polarization may be a potentially valuable therapeutic strategy for UC. Evidence has shown that traditional Chinese medicine (TCM) has positive therapeutic effects on UC by restoring the balance of M1/M2 macrophage polarization. This review summarizes the clinical evidence of TCM for UC, the vital role of macrophage polarization in the pathophysiology of UC, and the potential mechanism of TCM regulating macrophage polarization in the treatment of UC. We hope this review may provide some new enlightenment for the clinical treatment, fundamental research, and research and development of new Chinese medicine of UC.

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“…Systematic reviews (SRs)/meta-analyses (MAs) are considered the highest level of evidence in evidence-based medicine, yet inconsistent results may interfere with evidence-based decision-making [ 11 , 12 ]. BXD has been widely used in the treatment of GERD in China and is highly effective due to its multicomponent and multitarget characteristics [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Treatment of the Gastroesophageal Reflux Disease with Chinese Herbal Medicine (BanxiaXiexin Decoction): Evidence from Meta-Analysis

Liu

Huang

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objectives. Systematic reviews/meta-analyses (SRs/MAs) are still controversial on the effectiveness of Banxia Xiexin decoction (BXD) to treat gastroesophageal reflux disease (GERD). To assess the evidence reliability and inform the clinical use of BXD, we performed a meta-analysis from previous SRs/MAs to collate, critically appraise, and synthesize the effectiveness of BXD treatment in GERD. Methods. SRs/MAs were collected by searching major medical databases. The included studies were evaluated in terms of methodological quality and quality of evidence using criteria from the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) tool, and the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system, respectively. Results. Six SRs/MAs were included in this study. The methodological quality of SRs/MAs was generally unsatisfactory. Unregistered protocols, failure to provide a list of excluded trials, and lack of a comprehensive search strategy were the main limitations of previous SRs/MAs. No high-quality evidence was found to support the effect of BXD on GERD patients. The qualitative data synthesis relied on low-quality trials with a small sample size, which was the main factor for evidence degradation. Conclusions. BXD seems to have promising efficacy to treat GERD patients. Although the quality of SRs/MAs was generally low and defects were frequent, our study highlights areas where methodologies need to be improved.

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Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis

Cited by 17 publications

References 21 publications

An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of Acupuncture for Cancer Pain

An Overview of Systematic Reviews and Meta-Analyses of Clinical Studies of Acupuncture for Cancer Pain

A potential therapeutic target in traditional Chinese medicine for ulcerative colitis: Macrophage polarization

Treatment of the Gastroesophageal Reflux Disease with Chinese Herbal Medicine (BanxiaXiexin Decoction): Evidence from Meta-Analysis

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