Scientific Advances and the Evolution of Diagnosis, Subclassification and Treatment of Lymphoma

Ferry, Judith A.

doi:10.1016/j.arcmed.2020.05.022

Cited by 7 publications

(6 citation statements)

References 91 publications

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“…PIML can initially present with optic nerve damage, increased intracranial pressure, a high degree of malignancy, a specific release site, and a poor prognosis ( 17 ). The prognosis of this rare type of lymphoma, in which non-Hodgkin’s lymphoma is the main type, has improved over the last decade due to the use of high doses of methotrexate ( 18 ). However, the prognosis of PIML depends on several other factors, such as the time of diagnosis, histological and biological characteristics of the tumor, and the appropriateness of the treatment ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram to predict overall survival and cancer-specific survival in patients with primary intracranial malignant lymphoma: A Retrospective study based on the SEER database

Zhang

et al. 2023

Front. Oncol.

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IntroductionPrimary intracranial malignant lymphoma (PIML) is a rare form of lymphoma that most often occurs in the brain and has an extremely low 5-year survival rate. Although chemotherapy and radiotherapy are widely used in the clinical management of PIML, the choice of treatment regimen and the actual circumstances of patients remain challenges when assessing survival rates in different patients.MethodsConsidering this, we obtained clinical treatment and survival information from the Surveillance, Epidemiology, and End Results database (SEER) on patients with lymphoma, the primary site of which was the brain, and performed statistical analyses of the demographic characteristics. Survival analyses were performed using the Kaplan–Meier method, and univariate and multivariate Cox proportional hazards regression analyses were performed to identify independent prognostic factors.ResultWe identified age, pathology, the Ann Arbor stage, and treatment as the risk factors affecting patient prognosis. The areas under the curve (AUCs) for overall survival at 1, 3, and 5 years were 0.8, 0.818, and 0.81, respectively. The AUCs for cancer-specific survival at 1, 3, and 5 years were 0.8, 0.79, and 0.79. The prediction ability in the development and verification cohorts was in good agreement with the actual values, while we plotted the clinical decision curves for the model, suggesting that the nomogram can provide benefits for clinical decision-making.ConclusionOur model provides a prognostic guide for patients with PIML and a reliable basis for clinicians.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram to predict overall survival and cancer-specific survival in patients with primary intracranial malignant lymphoma: A Retrospective study based on the SEER database

Zhang

et al. 2023

Front. Oncol.

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“…From the clinical point of view, we discriminate between two large families of lymphoma: the classical Hodgkin lymphoma (CHL) and the non-Hodgkin lymphoma (NHL). Therapeutic approach and prognosis are very different between these two types of neoplasm and even between their various histological subtypes [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. The need of a correct and rapid diagnosis is therefore crucial for channeling patients to a proper chemotherapy, improving survival rates.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Anterior Mediastinotomy: A Feasible Tool for Critical Lymphoma Patients

et al. 2021

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A significant part of all neoplasms growing in anterior mediastinum are lymphomas (25%). Achieving a correct diagnosis and a clear definition of a lymphoma’s subtype is crucial for beginning chemotherapy as soon as possible. However, most patients present a large mediastinal mass that compresses vessels and airway, with serious cardiorespiratory repercussions. Therefore, having multiple tools available to biopsy the lesion without worsening morbidity becomes fundamental. Patients enrolled in this study were unfit for a surgical biopsy in general anesthesia and the need to begin chemotherapy as fast as possible prompted us to avoid percutaneous fine needle aspiration to prevent diagnostic failures. Our observational study included 13 consecutive patients with radiological findings of anterior mediastinal mass. Ultrasonography was performed directly in the theatre to mark the lesion and to localize vessels and vascularized neoplastic tissue. Open biopsy was carried out in spontaneous breathing with a laryngeal mask and with short-acting medications for a rapid anesthesia, performing an anterior mediastinotomy. The mean operative time was 33.4 ± 6.2 min and spontaneous respiration was maintained throughout the procedure. No complications were reported. All patients were discharged in the first or second postoperative day after a chest X-ray (1.38 ± 0.5 days). The diagnostic yield of this approach was 100%. With the addition of ultrasonography right before the procedure and with spontaneous breathing, anterior mediastinotomy still represents a useful tool in critical patients that could hardly tolerate a general anesthesia. The diagnostic yield is high, and the low postoperative morbidity allows a rapid onset of chemotherapy.

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“…Over time, cytogenetic and molecular genetic techniques have been developed. Flow cytometry and immunohistochemical immunophenotypes combined with immunohistochemistry can accurately identify, diagnose and subclassify lymphoma and evaluate its abnormalities ( Ferry, 2020 ). The use of flow cytometry as a novel biological analytical tool has been shown in the domains of metabolic engineering, cancer biology, stem cell biology, immunology, microbiology, and virology.…”

Section: Raman Spectroscopymentioning

confidence: 99%

Advances in the application of Raman spectroscopy in haematological tumours

Liang

Shi

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Hematologic malignancies are a diverse collection of cancers that affect the blood, bone marrow, and organs. They have a very unpredictable prognosis and recur after treatment. Leukemia, lymphoma, and myeloma are the most prevalent symptoms. Despite advancements in chemotherapy and supportive care, the incidence rate and mortality of patients with hematological malignancies remain high. Additionally, there are issues with the clinical diagnosis because several hematological malignancies lack defined, systematic diagnostic criteria. This work provided an overview of the fundamentals, benefits, and limitations of Raman spectroscopy and its use in hematological cancers. The alterations of trace substances can be recognized using Raman spectroscopy. High sensitivity, non-destructive, quick, real-time, and other attributes define it. Clinicians must promptly identify disorders and keep track of analytes in biological fluids. For instance, surface-enhanced Raman spectroscopy is employed in diagnosing gene mutations in myelodysplastic syndromes due to its high sensitivity and multiple detection benefits. Serum indicators for multiple myeloma have been routinely used for detection. The simultaneous observation of DNA strand modifications and the production of new molecular bonds by tip-enhanced Raman spectroscopy is of tremendous significance for diagnosing lymphoma and multiple myeloma with unidentified diagnostic criteria.

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Scientific Advances and the Evolution of Diagnosis, Subclassification and Treatment of Lymphoma

Cited by 7 publications

References 91 publications

Development and validation of a nomogram to predict overall survival and cancer-specific survival in patients with primary intracranial malignant lymphoma: A Retrospective study based on the SEER database

Development and validation of a nomogram to predict overall survival and cancer-specific survival in patients with primary intracranial malignant lymphoma: A Retrospective study based on the SEER database

Ultrasound-Guided Anterior Mediastinotomy: A Feasible Tool for Critical Lymphoma Patients

Advances in the application of Raman spectroscopy in haematological tumours

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