Science-based strategies of antibacterial coatings with bactericidal properties for biomedical and healthcare settings

Pemmada, Rakesh; Shrivastava, Aishwarya; Dash, Madhusmita; Cui, Kuiyan; Kumar, Prasoon; Ramakrishna, Seeram; Zhou, Youhe; Thomas, Vinoy; Nanda, Himansu Sekhar

doi:10.1016/j.cobme.2022.100442

Cited by 4 publications

(2 citation statements)

References 73 publications

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“…The production of proteins and DNA can be hampered by ions because of their ability to bind to functional groups. Many different modes of action have been proposed, and it is believed that several of these processes can operate in combination [ 141 , 142 , 143 , 144 ].…”

Section: Nanostructured Carriersmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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Wounds, which are becoming more common as a result of traumas, surgery, burns, and chronic illnesses like diabetes, remain a critical medical problem. Infectious bacteria impact the healing process, particularly if its biofilm (biological films) leads to a prolonged effect. Nanomaterials have emerged as promising candidates in the field of wound healing due to their unique properties and versatile applications. New insights into the interactions between nanomaterials and wound microenvironments have shed light on the mechanisms underlying their therapeutic effects. However, a significantly minimal amount of research has been carried out to see if these nanomaterials significantly promote the wound healing process. In this review, we provided an outline of the various types of nanomaterials that have been studied for healing wounds and infection prevention. Overall, the utilization of nanomaterials in wound healing holds great promise and continues to evolve, providing new opportunities for the development of effective and efficient wound care therapies.

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Section: Nanostructured Carriersmentioning

confidence: 99%

Nanomaterials in the Wound Healing Process: New Insights and Advancements

Sangnim,

Puri,

Dheer

et al. 2024

Pharmaceutics

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“…The composition of sessile cells within the matrix is heterogeneous, with irregular distribution (mixed species) covered with the matrix of EPS. This extracellular matrix was reported to be formed mainly of insoluble polysaccharides like alginate, proteins, lipids, flagella, pili, and extracellular DNA (eDNA) [ 14 ]. Biofilms represent a microbial organization resulting from an evolutionary defense mechanism by organisms to protect themselves from unfavorable environmental conditions outside the extracellular matrix.…”

Section: Relevance Of Biofilms In the Biomedical Fieldmentioning

confidence: 99%

Advances in Material Modification with Smart Functional Polymers for Combating Biofilms in Biomedical Applications

Mejía-Manzano,

Vázquez-Villegas,

Prado-Cervantes

et al. 2023

Polymers

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Biofilms as living microorganism communities are found anywhere, and for the healthcare sector, these constitute a threat and allied mechanism for health-associated or nosocomial infections. This review states the basis of biofilms and their formation. It focuses on their relevance for the biomedical sector, generalities, and the major advances in modified or new synthesized materials to prevent or control biofilm formation in biomedicine. Biofilm is conceptualized as an aggregate of cells highly communicated in an extracellular matrix, which the formation obeys to molecular and genetic basis. The biofilm offers protection to microorganisms from unfavorable environmental conditions. The most frequent genera of microorganisms forming biofilms and reported in infections are Staphylococcus spp., Escherichia spp., and Candida spp. in implants, heart valves, catheters, medical devices, and prostheses. During the last decade, biofilms have been most commonly related to health-associated infections and deaths in Europe, the United States, and Mexico. Smart, functional polymers are materials capable of responding to diverse stimuli. These represent a strategy to fight against biofilms through the modification or synthesis of new materials. Polypropylene and poly-N-isopropyl acrylamide were used enough in the literature analysis performed. Even smart polymers serve as delivery systems for other substances, such as antibiotics, for biofilm control.

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