“…Sex hormones, 17-β-estradiol (E 2 ) and testosterone, have important roles in their normal development (for recent reviews see Ball et al, 2014, Panzica andMelcangi, 2016), whereas several endocrine disruptors compounds (EDCs), at least those classified as xenoestrogens or xenoandrogens, may affect their normal development (Panzica et al, 2011). The presence of EDCs in the environment increased in the last 50 years and only recently their effects were under scientific evaluation and legislative regulation (Bourguignon et al, 2016. Many studies indicate that EDCs stimulation, during peri-and post-natal critical periods, may interfere with the formation of neuronal networks in a sex specific manner either binding or biasing the turnover of estrogen receptors (for a reviews see Panzica et al, 2007, Gore andDickerson, 2012).…”