Science and Ethics: Bridge to the Future for Regenerative Medicine

Ventura-Juncá, Patricio

doi:10.15283/ijsc.2011.4.2.79

Cited by 2 publications

(3 citation statements)

References 34 publications

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“…Finally, TE should not merely be aimed at treating disease, but also at improving overall quality of life 20 and promoting human flourishing. 153 …”

Section: Resultsmentioning

confidence: 99%

“… 70 , 75 , 81 In addition to the known risks, TE involves inherent uncertainties, because of the complexity and manufacturing variability of the construct, 23 , 71 , 159 and because the predictive value of preclinical animal studies is limited. 3 , 153 As a result it is challenging to provide a realistic risk-benefit analysis, 88 , 104 , 160 and to decide when evidence suffices to start first-in-human trials. 80 , 161 …”

Section: Resultsmentioning

confidence: 99%

“…Finally, global regulations to guide the application of experimental TE and RM treatments as innovative therapy outside clinical trials are needed. 19 , 122 , 153 …”

Section: Resultsmentioning

confidence: 99%

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The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

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Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs after injury or disease. Over the last decade, emerging technologies such as 3D bioprinting, biofabrication, supramolecular materials, induced pluripotent stem cells, and organoids have entered the field. While this rapidly evolving field is expected to have great therapeutic potential, its development from bench to bedside presents several ethical and societal challenges. To make sure TE will reach its ultimate goal of improving patient welfare, these challenges should be mapped out and evaluated. Therefore, we performed a systematic review of the ethical implications of the development and application of TE for regenerative purposes, as mentioned in the academic literature. A search query in PubMed, Embase, Scopus, and PhilPapers yielded 2451 unique articles. After systematic screening, 237 relevant ethical and biomedical articles published between 2008 and 2021 were included in our review. We identified a broad range of ethical implications that could be categorized under 10 themes. Seven themes trace the development from bench to bedside: (1) animal experimentation, (2) handling human tissue, (3) informed consent, (4) therapeutic potential, (5) risk and safety, (6) clinical translation, and (7) societal impact. Three themes represent ethical safeguards relevant to all developmental phases: (8) scientific integrity, (9) regulation, and (10) patient and public involvement. This review reveals that since 2008 a significant body of literature has emerged on how to design clinical trials for TE in a responsible manner. However, several topics remain in need of more attention. These include the acceptability of alternative translational pathways outside clinical trials, soft impacts on society and questions of ownership over engineered tissues. Overall, this overview of the ethical and societal implications of the field will help promote responsible development of new interventions in TE and RM. It can also serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. Impact statement To our knowledge, this is the first time that the ethical implications of Tissue Engineering (TE) have been reviewed systematically. By gathering existing scholarly work and identifying knowledge gaps, this review facilitates further research into the ethical and societal implications of TE and Regenerative Medicine (RM) and other emerging biomedical technologies. Moreover, it will serve as a valuable resource and educational tool for scientists, engineers, and clinicians in the field by providing an overview of the ethical considerations relevant to their work. As such, our review may promote successful and responsible development of new strategies in TE and RM.

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“…Finally, TE should not merely be aimed at treating disease, but also at improving overall quality of life 20 and promoting human flourishing. 153 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Kanter

Jongsma

Verhaar

et al. 2023

Tissue Engineering Part B: Reviews

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Ethical Aspects of Social Research: Old Concerns in the Face of New Challenges and Paradoxes. A Reflection from the Field of Biographical Method

Kaźmierska

2020

QSR

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The paper deals with the ethical aspects of the research process and contemporary changes in this field, which make the discussion on ethical dilemmas and concerns more dynamic and varied. Although in natural science and social sciences one can find a common ground related to the most general ethical principles. In the article I refer primarily to the social sciences. The article discusses three aspects affecting the dynamics of ethical discussions: the development of research in the field of natural sciences leading to many ethical dilemmas and forcing ethical codification of research proceedings also in the area of social sciences; the increase in sensitivity and social consciousness and not only awareness of research as such (processes of democratization, emphasizing human and animal rights, protection of minority rights, the process of individualization); the dynamics of contemporary social changes resulting from the development of technology, especially the Internet, which has become a global resource of data and their exchange. This forces qualitative researchers to consider the issue of data archiving, their reanalysis, and determining the boundary for creating Big Qualidata from them. The article discusses these three dimensions, with particular emphasis on the last of them, which will be commented on in relation to the specific methodological approach, which is biographical research.

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Science and Ethics: Bridge to the Future for Regenerative Medicine

Cited by 2 publications

References 34 publications

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

The Ethical Implications of Tissue Engineering for Regenerative Purposes: A Systematic Review

Ethical Aspects of Social Research: Old Concerns in the Face of New Challenges and Paradoxes. A Reflection from the Field of Biographical Method

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