We are pleased to introduce the Special Issue, Culture and Science Education in the 21st Century. In the past 20 years, the concept of culture has become more prominent and relevant in science education. The culture of science, culture of school science, culture of science classrooms, and cultures of individual actors in the science educative process are among the many ways in which culture has been cast and examined in the science education literature. Many studies described culture and examined its role in the participation in and the teaching and learning of science but fewer studies comprehensively entertained culture as a structure and mechanism that can inform research and policies developed to address the numerous challenges in science education.Approaching culture as structure necessitates thinking simultaneously about local and global settings and their micro-and macro-organizing frames as well as thinking holistically, placing the local and global and the micro and macro within both historical and contemporary times. On one hand, thinking of culture as structure requires in-depth investigations that are rich and deconstructive in nature, two of many characteristics of cultural studies in science education over the past 20 years. On the other hand, if culture becomes a tool in addressing systemic issues in systemic ways then it is necessary for some research studies to be adaptable to large-scale economies. If both hands work together then culture can become a vehicle to not only advancing our understanding about an equitable, robust science education for the 21st century but for acting in systemic ways to create it. The articles contained in the Special Issue provide an impetus for continued conversations about the definition, relevance, and the visionary uses of culture.We came to this co-editing endeavor with different ideas about culture. Our differences prompted interesting and provocative conversations between us. We are excited about this Special Issue because each article forwards a different approach to study culture and applies the concept to different problems of science education. We see this diversity of perspectives as a strength; it reminds us of the notion of crystallization discussed as a research strategy in texts about qualitative research methodology (Tracy, 2010). Rather than use data to come up with a more valid, singular truth, the goal of crystallization is to leverage multiple data,