Sciatic pain by neurolymphomatosis as initial presentation of disseminated diffuse large B cell lymphoma involving the testis and the CNS

Facchinelli, Davide; Ciliberti, Esteban; Stüssi, Georg; Ceriani, Luca; Zucca, Emanuele

doi:10.1002/hon.2698

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Solid organ primary diffuse large B-cell lymphoma rarely presents with signs and symptoms of neurolymphomatosis, including, to our knowledge, only two previous cases in the literature in which a testicular lymphoma was discovered after a patient presented with a set of neurological symptoms resulting from a secondary neurolymphomatosis. [6,7] In a previous review of the literature highlighting 23 cases of NL involving the lumbar / sacral nerves, nerve involvement was the primary finding, without evidence of solid organ involvement by lymphoma. [8] Additionally, in another larger series, only 11 of 72 patients diagnosed with NL were found to have concurrent systemic involvement by lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Testicular Lymphoma manifesting as neurological symptoms due to secondary neurolymphomatosis: A case report

Haslett¹,

Ulano²,

DeWitt³

2021

CRCP

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Neurolymphomatosis is a rare manifestation of lymphoma presenting as diffuse invasion and involvement of peripheral and spinal nerves. Due to the common presenting symptomatology of neurologic complaints localizing to the affected peripheral nerve, lymphoma as the underlying etiology can be diffificult to diagnose. Here we present the case of a gentleman presenting with right extremity neuropathic symptoms, subsequently discovered to have diffuse large B-cell lymphoma of testiticular orgin after nerve biopsy revealed neurolymphomatous involvement of a spinal nerve. This case highlights the importance of the consideration of neurolymphomatosis in the work up of neuropathic symptoms, as well as the full assessment for the site of primary involvement.

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Section: Discussionmentioning

confidence: 99%

Testicular Lymphoma manifesting as neurological symptoms due to secondary neurolymphomatosis: A case report

Haslett¹,

Ulano²,

DeWitt³

2021

CRCP

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“…Primary NL without systemic involvement is extremely rare and tends to have a predilection for the sciatic nerve [6,10,11]. The pathogenesis of this preferential involvement of the sciatic nerve has been debated.…”

Section: B Amentioning

confidence: 99%

Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

Kim

Rok

et al. 2021

Yeungnam Univ J Med

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Neurolymphomatosis (NL), defined as lymphocytic invasion of the peripheral nervous system in a hematologic malignancy setting, is a rare form of lymphoma that may occur as an initial presentation or recurrence [1]. Involvement of the peripheral nerves, spinal nerve roots, nerve plexus, cranial nerves, and multiple sites has been reported [2]. Since its characteristic symptoms vary according to the site of involvement, physicians might fail to obtain an accurate diagnosis. NL should be discriminated from other neuro-

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Sciatic diffuse large B-cell lymphoma with treatment response to CHOP and radiotherapy

Shomal Zadeh,

Khan,

Pooyan

et al. 2024

Radiology Case Reports

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Sciatic pain by neurolymphomatosis as initial presentation of disseminated diffuse large B cell lymphoma involving the testis and the CNS

Cited by 3 publications

References 11 publications

Testicular Lymphoma manifesting as neurological symptoms due to secondary neurolymphomatosis: A case report

Testicular Lymphoma manifesting as neurological symptoms due to secondary neurolymphomatosis: A case report

Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

Sciatic diffuse large B-cell lymphoma with treatment response to CHOP and radiotherapy

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