Sciatic Nerve Structural and Functional Recovery with Extract of Phyllanthus amarus and Esculetin in STZ-Induced Hyperglycemic Rats

Srilatha, Kota; Reddy, K. Pratap

doi:10.1177/0972753120911840

Cited by 8 publications

(2 citation statements)

References 48 publications

(46 reference statements)

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“…Prabakaran et al [ 91 ] found that oral administration of esculetin (10–40 mg/kg) significantly reduced blood glucose levels and increased plasma insulin levels in diabetic rats, and ameliorated diabetes-induced tissue damage in the liver and kidney by attenuating hyperglycemia-mediated oxidative stress. Furthermore, esculetin has been demonstrated to have protective effects against diabetes-induced complications such as nerve damage, [ 92 ] and vascular dysfunction. [ 93 ]…”

Section: Pharmacological Activities Of Esculetinmentioning

confidence: 99%

Pharmacological activities of esculin and esculetin: A review

Cai,

Cai

2023

Medicine

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Esculin and esculetin are 2 widely studied coumarin components of Cortex Fraxini, which is a well-known herbal medicine with a 2000-year history. In vivo and in vitro studies have demonstrated that both have a variety of pharmacological activities, including antioxidant, anti-tumor, anti-inflammatory, antibacterial, antidiabetic, immunomodulatory, anti-atherosclerotic, and so on. Their underlying mechanisms of action and biological activities include scavenging free radicals, modulating the nuclear factor erythroid 2-related factor 2 pathway, regulating the cell cycle, inhibiting tumor cell proliferation and migration, promoting mitochondrial pathway apoptosis, inhibiting the NF-κB and MAPK signaling pathways, regulating CD4+ T cells differentiation and associated cytokine release, inhibiting vascular smooth muscle cells, etc. This review aims to provide comprehensive information on pharmacological studies of esculin and esculetin, which is of noteworthy importance in exploring the therapeutic potential of both coumarin compounds.

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Section: Pharmacological Activities Of Esculetinmentioning

confidence: 99%

Pharmacological activities of esculin and esculetin: A review

Cai,

Cai

2023

Medicine

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“…The effects of esculetin on numerous cancer cell types have been extensively studied ( 94 , 321 – 342 , 519 , 524 , 525 ) and are the basis for efforts to develop novel therapeutics ( 98 , 341 ). Neuroprotective and behavioral actions of esculetin have also been described ( 111 , 299 , 367 – 371 , 526 – 528 ). Selected publications highlighting these effects of esculetin are featured in Table 3 .…”

Section: Effects Of Bioactive Compounds Found In a Scopariamentioning

confidence: 99%

Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use

et al. 2022

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Botanicals have a long history of medicinal use for a multitude of ailments, and many modern pharmaceuticals were originally isolated from plants or derived from phytochemicals. Among these, artemisinin, first isolated from Artemisia annua, is the foundation for standard anti-malarial therapies. Plants of the genus Artemisia are among the most common herbal remedies across Asia and Central Europe. The species Artemisia scoparia (SCOPA) is widely used in traditional folk medicine for various liver diseases and inflammatory conditions, as well as for infections, fever, pain, cancer, and diabetes. Modern in vivo and in vitro studies have now investigated SCOPA’s effects on these pathologies and its ability to mitigate hepatotoxicity, oxidative stress, obesity, diabetes, and other disease states. This review focuses on the effects of SCOPA that are particularly relevant to metabolic health. Indeed, in recent years, an ethanolic extract of SCOPA has been shown to enhance differentiation of cultured adipocytes and to share some properties of thiazolidinediones (TZDs), a class of insulin-sensitizing agonists of the adipogenic transcription factor PPARγ. In a mouse model of diet-induced obesity, SCOPA diet supplementation lowered fasting insulin and glucose levels, while inducing metabolically favorable changes in adipose tissue and liver. These observations are consistent with many lines of evidence from various tissues and cell types known to contribute to metabolic homeostasis, including immune cells, hepatocytes, and pancreatic beta-cells. Compounds belonging to several classes of phytochemicals have been implicated in these effects, and we provide an overview of these bioactives. The ongoing global epidemics of obesity and metabolic disease clearly require novel therapeutic approaches. While the mechanisms involved in SCOPA’s effects on metabolic, anti-inflammatory, and oxidative stress pathways are not fully characterized, current data support further investigation of this plant and its bioactives as potential therapeutic agents in obesity-related metabolic dysfunction and many other conditions.

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