Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome

Vogelaar, Christina Francisca; Vrinten, Dorien H.; Hoekman, Marco F.M.; Brakkee, Jan H.; Burbach, J. Peter H.; Hamers, Frank P.T.

doi:10.1016/j.brainres.2004.08.036

Cited by 97 publications

(59 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The motor function recovery of sciatic nerve in this study was in agreement with the previous study which had reported that the motor function recovery in the foot showed fully recovery after sciatic nerve crush injury within 3 weeks (Vogelaar et al, 2004). It has been reported that after nerve crush injury, the neuropathic pain which manifested as allodynia has been developed within the first 3 weeks (Attal et al, 1994;Kingery et al, 1994;Przewlocki et al, 1999;Vogelaar et al, 2004). Thus, the slow recovery process of the sensory nerve observed in this study may occur partly due to the development of neuropathic pain which takes much longer to resolve.…”

Section: Discussionsupporting

confidence: 93%

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

Mucimapura¹,

Thongrong²,

Chaisiwamongkol³

et al. 2010

American Journal of Agricultural and Biological Sciences

View full text Add to dashboard Cite

Problem statement: Traumatic nerve injury has been recognized as one of the problems commonly found in road traffic crashes. Therefore, searching for the effective substances for promoting the functional recovery of nerve after injury is in required. Accumulating lines of evidence show that free radicals generated after injury contribute the important role to retard functional recovery, thus the substance possessing anti-oxidant could facilitate functional recovery. Based on the effect of antioxidant to promote functional recovery of nerve after injury mentioned earlier, we hypothesized that Morus alba extract, a substance possessing anti-oxidant activity, should be able to facilitate the functional recovery of peripheral nerve after injury. Approach: To elucidate this issue, male Wistar rats, weighing 180-220 g, were orally given the aqueous extract of Morus alba at various doses ranging from 0.1, 1 and 10 mg kg −1 BW 5days before and 21 days after sciatic nerve injury.Motor, sensory and sensorimotor coordination were observed every 3 days for 3 weeks by using De Medinacelli method, foot reflex withdrawal test and rotarod test, respectively. Results: The low dose of the extract significantly improved both sensory and motor functions after crush injury. Although sensory function recovers more sooner than the motor function, it fails to show full recovery within weeks. Thus, the present study demonstrates the potential of M. alba extract to enhance functional recovery after crush injury. Conclusion: In conclusion, Morus alba may serve as functional food to promote nerve recovery after injury. However, further studies about the possible active ingredient (s) and underlying mechanism (s) are required.

show abstract

Section: Discussionsupporting

confidence: 93%

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

Mucimapura¹,

Thongrong²,

Chaisiwamongkol³

et al. 2010

American Journal of Agricultural and Biological Sciences

View full text Add to dashboard Cite

show abstract

“…Using the CatWalk-automated gait analysis method, we found that focal ischemia led to a persistent reduction in paw pressure and maximal area of paw contact. These gait impairments are likely because of an altered use of the plantar surface of the paw, a pattern commonly observed in other models of central nervous system injury including sciatic nerve resection, spinal cord injury, Parkinson's disease, and pain (Gabriel et al, 2007;Gensel et al, 2006;Vlamings et al, 2007;Vogelaar et al, 2004). The absolute values and impairment in foot print intensity and paw contact area were always greater in the forepaws than hindpaws of ischemic rats, possibly because the forepaws play a more important role in supporting the body weight during walking.…”

Section: Comparing Gait Impairments After Ischemic Stroke With Other mentioning

confidence: 99%

A Comprehensive Analysis of Gait Impairment after Experimental Stroke and the Therapeutic Effect of Environmental Enrichment in Rats

Wang

Bontempi

Hong

et al. 2008

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Although gait changes are considered as reliable indices of stroke severity and efficacy of rehabilitative therapies in humans, data from animal models of focal ischemia are lacking. To determine the effect of stroke on gait function in adult rats with distal middle cerebral artery occlusion (MCAO), we assessed the longitudinal changes in gait using an automated computerassisted gait analysis system. Four days after MCAO, intensity, maximal area of contact, and paw angle were significantly decreased in the affected forepaw whereas the double support time using ipsilateral paws increased. Relative print positions between the fore and hindpaws and limb coupling were also altered, suggesting that stroke affected sensorimotor status and reduced limb coordination. Except for paw angle, these impairments persisted for at least 5 weeks. However, unlike human stroke patients, stride length and stance were not affected in rats with MCAO. Environmental enrichment for 4 weeks improved paw contact area and relative print position of the affected limb and reduced double support time in ischemic rats compared with controls. Our results indicate that gait analysis provides great insight into various aspects of motor function changes in ischemic quadrupeds, and that environmental enrichment is beneficial in reducing a variety of poststroke gait impairments possibly through enhanced structural plasticity mechanisms within injured cortical neuronal networks underlying locomotor function.

show abstract

“…In sciatic nerve crushed injury model, Vogelaar et al (2004) reported that although sensory and motor reinnervation of the paw are fully established after nerve injury, persistent pain still exists and the animals can not support their weight on the injured paw. In the acute stage of sciatic crushed nerve injury, we observed that the flexion contracture of the toes and a curvation of the feet make impossible to calculate SFI in some rats.…”

Section: Discussionmentioning

confidence: 99%

Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

Ryu¹,

Lim²,

Song³

et al. 2009

Exp Neurobiol

View full text Add to dashboard Cite

Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. c-Fos expression is sometimes used as a marker of increased neuronal activity. We have developed herbal bath "HAC" for pain control using the following herbs: Harpagophytum procumbens, Atractylodes japonica, and Corydalis tuber. In the present study, we investigated the effects of herbal bath "HAC" on the recovery rate of the locomotor function and the expression of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region of brain following sciatic crushed nerve injury in rats. Walking track analysis for the evaluation of functional recovery and immunohistochemistry for the c-Fos expression were used for this study. In the present results, characteristic gait change with dropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG was suppressed following sciatic crushed nerve injury in rats. Immersion into herbal bath "HAC" enhanced SFI value and restored c-Fos expression in the vlPAG to the control value. These results suggest that herbal bath "HAC" might activate neurons in the vlPAG, and it facilitates functional recovery from peripheral nerve injury. Here we showed that herbal bath "HAC" could be used as a new therapeutic intervention for pain control and functional recovery from peripheral nerve injury.

show abstract

Sciatic nerve regeneration in mice and rats: recovery of sensory innervation is followed by a slowly retreating neuropathic pain-like syndrome

Cited by 97 publications

References 29 publications

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

A Comprehensive Analysis of Gait Impairment after Experimental Stroke and the Therapeutic Effect of Environmental Enrichment in Rats

Effects of Herbal Bath "HAC" on Functional Recovery and c-Fos Expression in the Ventrolateral Periaqueductal Gray Region after Sciatic Crushed Nerve Injury in Rats

Contact Info

Product

Resources

About