Scianna antigens including Rd are expressed by ERMAP

Wagner, Franz F.; Poole, Joyce; Flegel, Willy A.

doi:10.1182/blood-2002-07-2064

Cited by 51 publications

(70 citation statements)

References 30 publications

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“…The Sc2 allele is a consequence of the ERMAP(Gly57Arg) polymorphism found at a frequency of approximately 1% in Northern Europeans. Similarly, Radin is a consequence of ERMAP(Pro60Ala), a rarer allele (125).…”

Section: Other Butyrophilin Molecules: Btn1a1 Mog and Ermapmentioning

confidence: 99%

Regulation of Immunity by Butyrophilins

Rhodes

Reith

Trowsdale

2016

Annu. Rev. Immunol.

132

137

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Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk. They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276). These coreceptors modulate T cell responses upon antigen presentation by major histocompatibility complex and cognate αβ T cell receptor engagement. Molecules such as BTN3A1 (CD277), myelin oligodendrocyte glycoprotein, and mouse Skint1 and Btnl2, all members of the butyrophilin family, show greater structural and functional diversity than the canonical B7 receptors. Some butyrophilins mediate complex interactions between antigen-presenting cells and conventional αβ T cells, and others regulate the immune responses of specific γδ T cell subsets by mechanisms that have characteristics of both innate and adaptive immunity.

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Section: Other Butyrophilin Molecules: Btn1a1 Mog and Ermapmentioning

confidence: 99%

Regulation of Immunity by Butyrophilins

Rhodes

Reith

Trowsdale

2016

Annu. Rev. Immunol.

132

137

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“…Artificial DNA fragments were generated for the following LFAs and their antithetical HFA partners: SC2 (SC*02), LW [17][18][19][20][21]. Before use, artificial DNA fragments were titrated to equimolar copy concentrations as found in genomic DNA extracts from donor samples before validation.…”

Section: Blood Group Polymorphisms Snps Analyzed By Maldi-tof Ms 'Rmentioning

confidence: 99%

Low-Frequency Blood Group Antigens in Switzerland

Gassner

Degenhardt

Meyer

et al. 2018

Transfus Med Hemother

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Background: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested. Methods: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA). Results: 326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products. Conclusion: Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.

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“…These include Rh-ced (which encodes an allelic Rh antigen complex), Ermap (which encodes the Scianna blood group antigen 63,64 ), Duffy, and ICAM4 (also known as the LW antigen 65 ; Table 3). These genes were validated as EKLF target genes in the fetal liver by real-time PCR (Figures 1 and 3), although only Duffy and Ermap were significantly upregulated by tamoxifen in B1.6 cells ( Figure 1D).…”

Section: Blood Group Antigens and Eklfmentioning

confidence: 99%