Schwere Komplikationen nach intrathekaler Applikation von Methylenblau-Lösung

Steiner, Hans-Herbert; Steiner-Milz, H.G.

doi:10.1055/s-2007-1008070

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Intrathekale Gabe Von Methylenblau Ist Obsolet Leserbriefe K1

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“…In der Literatur sind viele Beispiele für schwere bis schwerste Komplikatio nen nach intrathekaler Methylenblau applikation beschrieben worden [1]. Steiner [2] propagierte daher bereits 1986 einen Verzicht auf Methylenblau als Indikatorfarbstoff zur Lokalisation eines Duralecks. Zudem ist das neuroto xische Methylenblau zurzeit in Deutsch land nicht mehr ohne weiteres als Me dikament zur intrathekalen Applikation erhältlich.…”

Section: Intrathekale Gabe Von Methylenblau Ist Obsolet Leserbriefe Kunclassified

Intrathekale Gabe von Methylenblau ist obsolet

Mameghani

2011

Unfallchirurg

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Section: Intrathekale Gabe Von Methylenblau Ist Obsolet Leserbriefe Kunclassified

Intrathekale Gabe von Methylenblau ist obsolet

Mameghani

2011

Unfallchirurg

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Cellular and molecular actions of Methylene Blue in the nervous system

Öz

Lorke

Al‐Hasan

et al. 2010

Medicinal Research Reviews

354

249

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Methylene Blue (MB), following its introduction to biology in the 19 th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide-induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article, these physicochemical features and the actions of MB on multiple cellular and molecular targets are discussed with regard to their relevance to the nervous system.

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Spinal methylene blue is hazardous

Levine

Richeimer

2011

Pain

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Schwere Komplikationen nach intrathekaler Applikation von Methylenblau-Lösung

Cited by 5 publications

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Intrathekale Gabe von Methylenblau ist obsolet

Intrathekale Gabe von Methylenblau ist obsolet

Cellular and molecular actions of Methylene Blue in the nervous system

Spinal methylene blue is hazardous

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