Schwere allergische Kontaktdermatitis mit generalisierter Streuung auf Bufexamac unter dem Bild eines „Baboon”-Syndroms

Abstract

During the last 10 years allergic reactions to bufexamac have increasingly been reported, sometimes with erythema multiforme-like reactions. Because of the high rate of sensitization, the serious clinical course of bufexamac allergy and the insidious symptoms of this side effect, sometimes mimicking the disease to be treated, the substance should be used neither for proctological nor for dermatological diseases, even more as these patients are considered to be at high risk of developing allergic contact dermatitis because of the abnormal skin barrier. Considering the data presented, the use of bufexamac should be critically reassessed.

EMA revokes marketing authorization for bufexamac

“…Dermatologists based in (European) countries where bufexamac is not marketed, such as Scandinavian countries or the United Kingdom, will probably not appreciate the above news. Those European dermatologists who have seen unfortunate patients with acute generalized Erythema exsudativum multiforme‐like, or severe baboon‐like, perianal (3) allergic contact dermatitis caused by bufexamac will certainly be relieved. However, if the above decision is only the favourable end‐point of an administrative decision‐making process, why is the ‘bufexamac story’ still worth telling?…”

Anogenitaldermatosen – allergische und irritative Auslösefaktoren Analyse von Daten des IVDK1 und Literaturübersicht

“…Überzeugende Berichte einer allergischen Kontaktdermatitis auf weitere Allergene sind in Tabelle 4a und b [8, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33] aufgeführt.…”

Das Analekzem und seine benignen Simulatoren

“…Die Analregion ist eine typische,aber weniger bekannte Prädilektionsstelle für das ato- [17] und Bufexamac [13].Beim Toilettenpapier sind Kathon C6 und Euxyl K400 potenzielle Auslöser [5]. Eine Sensibilisierung ist entsprechend dem immunologischen Vorgang vor allem nach jahrelangem Gebrauch der jeweiligen Substanz möglich.…”