Schwannomas of the Gastrointestinal Tract: Clinicopathological Features of 12 Cases Including a Case of Esophageal Tumor Compared with Those of Gastrointestinal Stromal Tumors and Leiomyomas of the Gastrointestinal Tract

Kwon, Mi Seon; Lee, Seung Sook; Ahn, Geung Hwan

doi:10.1078/0344-0338-00309

Cited by 93 publications

(105 citation statements)

References 22 publications

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“…Schwannomas are known to be benign neoplasms of ectodermal origin, which are characterized by a slow growth pattern with the capacity for malignant degeneration if not removed (4). This type of tumor typically manifests as a polyp that may ulcerate the mucosa, leading to non-specific symptoms, including abdominal pain with rectal bleeding, defecation disorders and colonic obstruction (5).…”

Section: Discussionmentioning

confidence: 99%

Transverse colon schwannoma treated by endoscopic mucosal resection: A case report

Ramai

Lai

Changela

et al. 2017

Molecular and Clinical Oncology

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Abstract. Gastrointestinal (GI) schwannoma is one of the rarest tumors of the GI tract. We herein describe the case of a 70-year-old female patient who presented for surveillance colonoscopy. The examination detected a 1-cm polyp that was removed by snare cautery polypectomy. Immune and histochemical staining revealed spindle cells that were positive for S-100 and vimentin, but negative for CD34 and smooth muscle actin, consistent with GI schwannoma. This case is noteworthy as GI schwannomas usually present in the stomach, making the finding of a colonic schwannoma of clinical interest. Furthermore, the present case was treated by removing the tumor endoscopically, in contrast to more invasive methods. IntroductionGastric schwannoma is slow-growing mesenchymal neoplasm that originates from Schwann cells (1). This is a rare subgroup of gastrointestinal stromal tumors (GISTs), which have low malignant potential, and are clinically distinct from other non-epithelial tumors of the gastrointestinal (GI) tract, including leiomyoma, leiomyosarcoma and GI autonomic neurogenic tumors. GI schwannomas account for ~2-6% of all submucosal tumors, and ~60-70% occur within the stomach (2). While this type of tumor rarely occurs in the bowel, schwannomas may develop in any anatomical region. While the majority of schwannomas are benign, it is important to accurately identify these tumors as they may mimic other malignant lesions of the GI tract. This report presents a case of a schwannoma found at the transverse colon upon surveillance colonoscopy, which was treated by endoscopic mucosal resection. Case reportA 70-year-old female patient was referred by her primary care physician for surveillance colonoscopy in January 2017. The patient reported no major symptoms, but complained of occasional episodes of diarrhea over the past month. The patient was a non-smoker and non-drinker, and review of the systems was negative for any weight loss. The finding on physical examination were unremarkable. The vital signs were stable, and the laboratory results were within normal limits. The patient underwent a colonoscopy, which revealed evidence of moderately severe diverticulosis in the sigmoid and descending colon. A single polyp, measuring 1 cm in size, was identified in the transverse colon. Saline was injected at the base to raise the polyp prior to removal (Fig. 1A). The polyp was completely removed by snare cautery polypectomy. To control bleeding, 2 clips were applied (Fig. 1B). Histological examination of the polyp showed a solid mass with peripheral colonic mucosa ( Fig. 2A). Higher resolution revealed fascicles of spindle cells exhibiting nuclear palisading ( Fig. 2B and C). Immunohistochemistry was positive for S-100 and vimentin, but negative for CD34 and smooth muscle actin, consistent with GI schwannoma. The patient made a good postoperative recovery. Consent was obtained from the patient regarding the publication of the case details and associated images. DiscussionGI schwannoma is an extremely rare intestinal mesenchymal tu...

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Section: Discussionmentioning

confidence: 99%

Transverse colon schwannoma treated by endoscopic mucosal resection: A case report

Ramai

Lai

Changela

et al. 2017

Molecular and Clinical Oncology

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“…5 They generally run a benign course. [12][13][14][15][16][17] However, isolated cases of ''malignant schwannomas'' have been reported. 2,18 Whether these malignant tumors arise de novo or from benign schwannomas remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Abdominal Schwannomas: Case Report With Literature Review

Shelat

Naik

et al. 2013

International Surgery

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Schwannomas are rare tumors that arise from Schwann cells in neural sheaths. They are commonly found in the central nervous system, spinal cord, or peripheral nerves of the body. Occasionally, they occur in the gastrointestinal tract, with the stomach being the most common site. However, colorectal and retroperitoneal schwannomas are very rare. Preoperative diagnosis is often difficult and definitive treatment entails surgical excision. We herein present 3 cases of intraabdominal schwannomas.

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“…Дифференциальную диагностику проводили прежде всего с гастроинтестинальной стромальной опухолью, которая является наиболее распространенным мезенхи-мальным новообразованием желудка; шваннома чрезвы-чайно близка к ней по клиническим и морфологическим признакам [8]. До 95% гастроинтестинальных стромаль-ных опухолей, в отличие от шванном, являются CD117-позитивными.…”

“…Доброкачественный или злокачественный тип опу-холи основывается главным образом на наличии атипии ядер, высокой митотической активности и гетероморфиз-ме опухолевых клеток; корреляции с какими-либо кли-ническими факторами авторами не было выявлено [2,5,8]. L. Zheng и соавт.…”

Gastric schwannoma

Скоропад¹,

Mozerov²,

Dvinskikh³

et al. 2016

Onkol. Z. im. P.A. Gercena

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Schwannomas of the Gastrointestinal Tract: Clinicopathological Features of 12 Cases Including a Case of Esophageal Tumor Compared with Those of Gastrointestinal Stromal Tumors and Leiomyomas of the Gastrointestinal Tract

Cited by 93 publications

References 22 publications

Transverse colon schwannoma treated by endoscopic mucosal resection: A case report

Transverse colon schwannoma treated by endoscopic mucosal resection: A case report

Abdominal Schwannomas: Case Report With Literature Review

Gastric schwannoma

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