Schwannoma of the submandibular gland

Abstract

Neurilemmomas (schwannomas) are solitary neurogenic tumors that arise from cells of the neural sheath. They are slow growing and represent a proliferation of Schwann cells. Extracranial neurogenic tumors of the head and neck are uncommon, with benign tumors occurring with greater frequency than malignant tumors. These tumors often mimic primary or metastatic disease in the head and neck. Schwannoma of the salivary gland is a particularly rare form of an extracranial neurogenic tumor, with most presenting in the parotid gland originating from a peripheral branch of the facial nerve. An unusual case of neurilemmoma of the submandibular gland is presented, and the literature concerning this subject is reviewed. We believe this tumor originated in an autonomic nerve of the submandibular gland. The mass was discrete and well demonstrated on CT scan. Total excision of the gland resulted in complete resolution of symptoms with no cranial nerve deficits.

Zur Klinik und Therapie des extratemporalen Fazialisneurinoms

“…Sie imponieren durch ein langsames Tumorwachstum und werden klinisch oftmals als pleomorphe Adenome eingestuft [7,8]. Nach vorliegender Literatur ist der überwiegende Manifestationsort extratemporaler Fazialisneurinome die Glandula parotis [3,12]. Eine maligne Transformation von Neurinomen kommt in der Regel nicht vor, die hierzu dokumentierten Einzelfälle müssen als Ausnahmeverläufe bewertet werden und haben für die Einordnung des Neurinoms als gutartigen Tumor keine Konsequenz [18].…”

“…Parotid gland · Neurinoma, extra-temporal · Facial nerve · Tumor resection · Exclusion of malignancy Extrakranielle Manifestationen sind sehr selten: In weitaus der Mehrzahl der Fälle ist hier der N.facialis mit seinen Aufzweigungen betroffen [4,14], mit einemnach vorliegender Literatur -Überwie-gen der Fazialisneurinome der Glandula parotis [3,12].…”

Sublingual Schwannoma: A Rare Clinical Entity reported in a Hypothyroid Female

“…1 They are also called neuromas or neurilemmomas. 2 They are common slow growing, solitary and wellencapsulated tumors derived from Schwann cells located at the sheaths of peripheral, cranial or autonomic nerves. 3 They are a solitary, encapsulated tumor usually attached to, or surrounded by a nerve, and are not associated with von Recklinghausen's disease and rarely show malignant degeneration.…”

Kliniğimizde tedavileri yapılan baş ve boyun schwannomlu olgular

“…Nörilemmoma, nörinom, perinöral fibroblastom, periferal gliom gibi değişik isimlerle de adlandırılan bu klinik tablo patolojik olarak ilk defa 1908 yılında Verocay tarafından tarif edilmiştir. Schwannomlar'ın %25-40'ı baş boyun bölgesinde yerleşim gösterir [4][5][6]. Nörilemmoma'lar lokalizasyon ve kaynaklandıkları sinire göre iki gruba ayrılır; son dört kranial sinirden köken alan parafarengeal schwannomlar medial grubu, servikal ve brakial pleksustan kaynaklanan servikal sempatik zincir schwannomları ise lateral grubu oluşturur [4].…”

“…Schwannomlar'ın %25-40'ı baş boyun bölgesinde yerleşim gösterir [4][5][6]. Nörilemmoma'lar lokalizasyon ve kaynaklandıkları sinire göre iki gruba ayrılır; son dört kranial sinirden köken alan parafarengeal schwannomlar medial grubu, servikal ve brakial pleksustan kaynaklanan servikal sempatik zincir schwannomları ise lateral grubu oluşturur [4]. Bu tümörler baş ve boyun bölgesinin yumuşak doku tümörleri içerisinde yer almakla birlikte farklı klinik seyirleri ve karakteristik özellikleri nedeniyle ayrı bir grupta değerlendirilmeleri gereklidir [7].…”