Schwannoma Located in the Upper Gingival Mucosa: Case Report and Literature Review

Sakanashi, Emi Nishijima; Sonobe, Junya; Chin, Motofumi

doi:10.1007/s12663-012-0445-8

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Ultra-structurally, Schwann cells show diffuse and strong nuclear and cytoplasmic staining with S-100, which is seen in our case. On the other hand, perineural cells and fibroblasts stain negative for S-100, which helps to distinguish non-neural pathologies and neural pathologies with mixed cellularity such as neurofibroma 7 . On the other hand, our tumor stained negative for Ki-67, which allowed us to rule out malignant behavior.…”

Section: Discussionmentioning

confidence: 99%

“…Conventional schwannomas are generally encapsulated, and thus the prognosis is excellent after surgical extirpation, provided that any associated nerve is saved 20 . Malignant transformation has been seen in epithelioid/cellular and plexiform variants 7 . The presence of atypia in an epithelioid schwannoma doesn’t confirm a malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

“…These cells appear as organized streaming fascicles in Antoni A, with areas of palisading nuclear arrangements around eosinophilic amorphous masses known as Verocay bodies. On the other hand, Antoni B areas are relatively paucicellular, with haphazardly arranged Schwann cells in a myxoid or loose stroma 1 , 4 , 6 , 7 . Cystic degeneration, thick hyalinized vessels, hemosiderin deposition, lipid-laden macrophages, and nuclear atypia (degenerative changes) are other features of schwannomas 8 .…”

Section: Introductionmentioning

confidence: 99%

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A rare histopathological variant of Schwannoma with rosette-like arrangements and epithelioid cells: a case report from a histopathologist’s perspective

Mehendiratta,

Sant,

Lakhanpal

et al. 2023

JKAOMS

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Schwannomas exhibit histopathological variation that leads to diagnostic dilemmas, although less frequent in the oral cavity. We describe a case with unique histopathology and no relevant clinical history that adds to the breadth of literature on the diversity presented by Schwannoma. A 60-year-old female patient presented with a small dome-shaped, asymptomatic swelling on the alveolar ridge 6 years in duration. Histopathologically, it showed rich cellular pathology with a unique arrangement of tumor cells forming irregular rosettes. Each rosette presented with a central core of fibrin-collagenous material and the tumor cells were arranged on the periphery, exhibiting epithelioid change with evidence of mild cellular and nuclear pleomorphism. On immunohistochemical evaluation, the cells were strongly and diffusely positive for S-100 and negative for Ki-67. A diagnosis of benign Schwannoma with a rosette-like arrangement with epithelioid change was made. The case report emphasizes the risk of misdiagnosis and the importance of awareness regarding rare histopathological variants of Schwannoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A rare histopathological variant of Schwannoma with rosette-like arrangements and epithelioid cells: a case report from a histopathologist’s perspective

Mehendiratta,

Sant,

Lakhanpal

et al. 2023

JKAOMS

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Comprehensive Analyses of Intraoral Benign and Malignant Nerve Sheath Tumors: The Rare Disease Entities Revisited

Song

et al. 2019

Journal of Craniofacial Surgery

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Introduction: Intraoral benign and malignant nerve sheath tumors (BNST and MNST) are rare tumors with non-specific clinical presentations and represent diagnostic and therapeutic challenges. Current knowledge regarding their demographic, clinicopathological features and treatments remains fragmented. Materials and Methods: The original data about patients diagnosed as intraoral BNST and MNST were retrieved from our disease registry (2005–2017). Comprehensive reviews of English and Chinese literature were performed to collect and analyze the epidemiological, clinicopathological data and treatment outcomes about those published cases. Results: Thirty-four intraoral BNSTs were found at our institution in the past 13 years. Literature reviews identified 354 intraoral BNSTs in 223 articles and 60 intraoral MNSTs in 50 articles. Most intraoral BNSTs and MNSTs were presented in the second to fifth decade of life. Males outnumbered females in MNSTs, while BNSTs displayed a slight female preponderance. The common sites for intraoral BNSTs were parapharyngeal space followed by tongue, whereas mandible was the most common site for MNSTs. Most intraoral BNSTs were presented as slow-growing, painless mass or swelling, while MNSTs usually appeared as painful and invasive mass with discomfort. Surgical excision was preferred for intraoral BNSTs with excellent prognosis. Complete resection was indicated for intraoral MNST with dismal prognosis as evidenced by much recurrence, metastasis, and death. Conclusion: Intraoral BNST and MNST are rare diseases which should not be ignored when intraoral painless or painful mass/swelling is found. Surgical excision is indicated for intraoral BNST with favorable outcomes. However, further investigations are warranted to optimize the treatment for intraoral MNST to improve its prognosis.

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Schwannoma Lingual: presentación de un caso y breve revisión de la literatura

Venturino¹,

Venturino²,

Sabas³

et al. 2021

Rev Asoc Odontol Argent

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Objetivo: Reportar un caso de schwannoma lingual, así como revisar las características diagnósticas (clínicas, por imágenes e histopatológicas) y terapéuticas de esta patología mediante las publicaciones disponibles. Caso clínico: Se presenta un caso de schwannoma intraoral en un hombre de 26 años de edad con un tumor ubicado en el tercio anterior de la lengua. Se resolvió mediante un único procedimiento quirúrgico bajo anestesia local sin observarse recidivas ni secuelas al menos a 12 meses de seguimiento a distancia. El schwannoma de la lengua es poco frecuente pero sus características clínico-imagenológicas presentan rasgos benignos que favorecen la resolución mediante una única biopsia quirúrgica total cuando el tamaño y la ubicación sean propicios para ello. Palabras clave: Intraoral, lingual, neurilemoma, schwannoma.

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Schwannoma Located in the Upper Gingival Mucosa: Case Report and Literature Review

Cited by 3 publications

References 12 publications

A rare histopathological variant of Schwannoma with rosette-like arrangements and epithelioid cells: a case report from a histopathologist’s perspective

A rare histopathological variant of Schwannoma with rosette-like arrangements and epithelioid cells: a case report from a histopathologist’s perspective

Comprehensive Analyses of Intraoral Benign and Malignant Nerve Sheath Tumors: The Rare Disease Entities Revisited

Schwannoma Lingual: presentación de un caso y breve revisión de la literatura

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