Schwannoma in the Sigmoid Colon. Report of a Case.

Sasatomi, Teruo; Tsuji, Yoshiaki; Tanaka, Toshiaki; Horiuchi, Hiroyuki; Hyodo, Shin; Takeuchi, Kiyoaki; Nakashima, Osamu; Shirouzu, Kazuo

doi:10.2739/kurumemedj.47.165

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…Discussion GI schwannomas are rare peripheral nerve sheath tumors that show a distinctive set of histologic features that differ from conventional central nervous system and peripheral, soft tissue schwannomas. These distinctive features include a peripheral lymphoid cuff, common microtrabecular pattern, and lack of nuclear palisading and xanthoma cells (Daimaru et al, 1988;Hirose et al, 1997;Miettinen et al, 2001;Prévot et al, 1999;Sarlomo-Rikala and Miettinen, 1995;Sasatomi et al, 2000;Scheithauer et al, 1999;Skopelitou et al, 1998;Tomozawa et al, 1998;Yagihashi et al, 1997). In this study, we evaluated NF2 and NF1 alterations in 20 well-documented GI schwannomas using archival formaldehyde-fixed, paraffinembedded (FFPE) material.…”

Section: Nf2 and Nf1 Status In Conventional Schwannomasmentioning

confidence: 99%

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confidence: 99%

“…The tumor cells are positive for S-100 protein and glial fibrillary acidic protein (GFAP) and negative for desmin and ␣-smooth muscle actin (SMA), unlike true leiomyomas, and negative for KIT (CD117) and CD34, unlike GI stromal tumors. All tumors with such phenotypic features reported thus far have followed a benign clinical course (Daimaru et al, 1988;Hirose et al, 1997;Miettinen et al, 2001;Prévot et al, 1999;Sarlomo-Rikala and Miettinen, 1995;Sasatomi et al, 2000;Skopelitou et al, 1998;Tomozawa et al, 1998;Yagihashi et al, 1997).Neurofibromatosis 2 (NF2) is an autosomal dominant disorder caused by genetic alterations of the NF2 tumor suppressor gene (Gutmann, 1997 1361 mapped to 22q12 and encodes for a protein designated as merlin or schwannomin (Hovens and Kaye, 2001;Rouleau et al, 1993;Trofatter et al, 1993). Bilateral vestibular schwannomas are a typical diagnostic feature of NF2.…”

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Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases

Lasota

Wasąg

Dansonka-Mieszkowska

et al. 2003

Laboratory Investigation

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SUMMARY:A significant percentage of conventional schwannomas, whether sporadic or associated with neurofibromatosis 2 (NF2), show loss of heterozygosity (LOH) at NF2 and/or NF2 inactivating mutations. Similarly, a significant percentage of neurofibromas show LOH at NF1 and/or NF1 inactivating mutations. There are no molecular genetic data on gastrointestinal (GI) nerve sheath tumors traditionally diagnosed as benign schwannomas, rare neoplasms possibly derived from the schwannian elements dispersed between the smooth muscle fibers. In this study, we analyzed 1 esophageal, 16 gastric, 1 small intestinal, and 2 colonic tumors of such type. Histologically, all were spindle cell neoplasms positive for S-100 protein, vimentin, and glial fibrillary acidic protein, and negative for smooth muscle markers, KIT, CD34, neurofilament proteins, and HMB45. Focal or extensive lymphoid cuffs, often containing germinal centers, were present in most cases. None of the patients had NF2 or NF1. Chromosomes 22 and 17, particularly NF2 and NF1 loci, were analyzed for LOH in all GI tumors and for comparative purposes in 10 conventional schwannomas. LOH on 22q was seen in 40% of conventional schwannomas but in only 5% (1 of 20) of GI schwannomas. PCR amplification followed by direct sequencing of PCR products failed to identify mutations in NF2 coding sequences (exons 1-15) in 13 cases, including a case with LOH on 22q. Losses on 17q involving NF1 were seen in both GI and conventional schwannomas in 50% and 33% of analyzed tumors, respectively. LOH at NF1 might be one of the genetic features seen in peripheral nerve sheath tumors from different locations and should be interpreted with caution. However, lack of NF2 alterations strongly supports the hypothesis that GI schwannomas represent a morphologically and genetically distinct group of peripheral nerve sheath tumors that are different from conventional schwannomas. (Lab Invest 2003, 83:1361-1371. Distinctive benign nerve sheath tumors traditionally diagnosed as schwannomas have been documented in the gastrointestinal (GI) tract. Their most common location is the stomach, followed by the colon and the rectum. Occasionally, similar tumors have been reported in the small intestine and esophagus. GI schwannomas are cellular spindle cell tumors with a microtrabecular pattern and lack of nuclear palisading. Peripheral lymphoid foci, sometimes with germinal center formation, are a common histologic feature. The tumor cells are positive for S-100 protein and glial fibrillary acidic protein (GFAP) and negative for desmin and ␣-smooth muscle actin (SMA), unlike true leiomyomas, and negative for KIT (CD117) and CD34, unlike GI stromal tumors. All tumors with such phenotypic features reported thus far have followed a benign clinical course (Daimaru et al, 1988;Hirose et al, 1997;Miettinen et al, 2001;Prévot et al, 1999;Sarlomo-Rikala and Miettinen, 1995;Sasatomi et al, 2000;Skopelitou et al, 1998;Tomozawa et al, 1998;Yagihashi et al, 1997).Neurofibromatosis 2 (NF2) is an autosomal dominant diso...

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Section: Nf2 and Nf1 Status In Conventional Schwannomasmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases

Lasota

Wasąg

Dansonka-Mieszkowska

et al. 2003

Laboratory Investigation

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“…1 They can present as intramucosal polypoid lesions with ulcerations. [2][3][4] In our case, the patient was asymptomatic and the finding was incidental. In a report of 20 colorectal schwannoma cases, three clinicopathologic types of Schwannoma were characterized: spindle cell, epithelioid, and plexiform.…”

Section: Rectal Schwannoma (Neurilemmoma)mentioning

confidence: 50%

Rectal Schwannoma (Neurilemmoma)

Vijayasekaran

Tsikitis

Gardetto

et al. 2012

The American Surgeon

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Brief Reports should be submitted online to www.editorialmanager.com/ amsurg. (See details online under ''Instructions for Authors''.) They should be no more than 4 double-spaced pages with no Abstract or sub-headings, with a maximum of four (4) references. If figures are included, they should be limited to two (2). The cost of printing color figures is the responsibility of the author.In general, authors of case reports should use the Brief Report format.

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“…Approximately 2-6% of gastrointestinal tract stromal tumors comprise Schwannomas [2], with the stomach being the most frequent site of manifestation [3]. Schwannomas arising from the colon with the non-existence of neurofibromatosis (NF) or parasitic infection are exceptionally rare [3][4][5][6], with even infrequent malignant cases. Till now, only six cases have been reported of MPNST arising from the colon [1,[7][8][9][10][11].…”

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Malignant peripheral nerve sheath tumor of the descending colon with peritoneal recurrence: A case report

Rane,

Patil,

Bagul

et al. 2024

Indian J Case Reports

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A malignant peripheral nerve sheath tumor (MPNST) is a malignant tumor devising from the peripheral nerve or displaying nerve sheath differentiation. Probably, only six cases have been reported as MPNST tumors arising in the colon. We report one such unique case of MPNST of the descending colon in a 61-year-old male who presented primarily with colicky abdominal pain for 1 month. Computed tomography (CT) showed a large mass in the descending colon. A left hemi-colectomy was performed, and a histopathological diagnosis of spindle cell sarcoma was made, which was confirmed as MPNST on immunohistochemistry (IHC). The patient again presented after 1 year with the same complaints of abdominal pain since 1 month. A CT scan revealed seven well-defined lesions in the peritoneal cavity, with the largest (8 cm) abutting the left kidney and one of the lesions abutting a small bowel segment. Exploratory laparotomy was performed with retroperitoneal mass excision and resection of the small intestine. The histopathological examination was suggestive of recurrent spindle cell sarcoma. The IHC showed S100 and CD56 positivity, which confirmed the diagnosis of recurrent MPNST.

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Schwannoma in the Sigmoid Colon. Report of a Case.

Cited by 10 publications

References 14 publications

Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases

Evaluation of NF2 and NF1 Tumor Suppressor Genes in Distinctive Gastrointestinal Nerve Sheath Tumors Traditionally Diagnosed as Benign Schwannomas: A Study of 20 Cases

Rectal Schwannoma (Neurilemmoma)

Malignant peripheral nerve sheath tumor of the descending colon with peritoneal recurrence: A case report

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