Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro

Hinson, A.W.; Gu, Xianfeng; Dib‐Hajj, Sulayman D.; Black, Joel A.; Waxman, Stephen G.

doi:10.1002/(sici)1098-1136(199712)21:4<339::aid-glia1>3.0.co;2-z

Cited by 26 publications

(22 citation statements)

References 71 publications

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“…In Amir and Devor’s computational modeling regulation of the sodium channel, density was restricted to soma and initial segments of the stem axon, which largely contradicts current evidence; sodium channel expression is highly dynamic and is regulated in both the soma and axon 49. Although the molecular signals that regulate sodium channel isoform expression, trafficking, clustering, and maintenance in axons are mostly unknown, there is evidence showing that growth factors, such as nerve growth factor and glial derived neurotrophic factor, as well as Schwann cells are involved in regulating sodium channel expression 50,51…”

Section: Discussionmentioning

confidence: 85%

Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

Henry²

2013

JPR

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PurposeTo determine conduction fidelity of Aα/β-fiber low threshold mechanoreceptors in a model of osteoarthritis (OA).MethodsFour weeks after cutting the anterior cruciate ligament and removing the medial meniscus to induce the model, in vivo intracellular recordings were made in ipsilateral L4 dorsal root ganglion neurons. L4 dorsal roots were stimulated to determine the refractory interval and the maximum following frequency of the evoked action potential (AP). Neurons exhibited two types of response to paired pulse stimulation.ResultsOne type of response was characterized by fractionation of the evoked AP into an initial nonmyelinated-spike and a later larger-amplitude somatic-spike at shorter interstimulus intervals. The other type of response was characterized by an all-or-none AP, where the second evoked AP failed altogether at shorter interstimulus intervals. In OA versus control animals, the refractory interval measured in paired pulse testing was less in all low threshold mechanoreceptors. With train stimulation, the maximum rising rate of the nonmyelinated-spike was greater in OA nonmuscle spindle low threshold mechanoreceptors, possibly due to changes in fast kinetics of currents. Maximum following frequency in Pacinian and muscle spindle neurons was greater in model animals compared to controls. Train stimulation also induced an inactivation and fractionation of the AP in neurons that showed fractionation of the AP in paired pulse testing. However, with train stimulation this fractionation followed a different time course, suggesting more than one type of inactivation.ConclusionThe data suggest that joint damage can lead to changes in the fidelity of AP conduction of large diameter sensory neurons, muscle spindle neurons in particular, arising from articular and nonarticular tissues in OA animals compared to controls. These changes might influence peripheral drive of spinal excitability and plasticity, thus contributing to OA sensory abnormalities, including OA pain.

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Section: Discussionmentioning

confidence: 85%

Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

Henry²

2013

JPR

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“…Rabbit of 66 months. × 5660 cells can provide trophic support to sensory neurons (Varon et al 1974;Heumann et al 1987;Taniuchi et al 1988), can influence neuronal maturation (Mudge 1984), axon diameter (Windebank et al 1985;Pannese et al 1988;de Waegh et al 1992;, the synthesis of specific enzymes (Fan and Katz 1993) as well as the molecular organization of the plasma membrane (Cooper and Lau 1986;Rosenbluth 1989;Joe and Angelides 1992;Hinson et al 1997;Rasband et al 1998). These cells also prevent dendrite formation on the sensory neurons with which they are associated (De Koninck et al 1993).…”

Section: Discussionmentioning

confidence: 99%

The perikaryal surface of spinal ganglion neurons: differences between domains in contact with satellite cells and in contact with the extracellular matrix

Pannese¹,

Procacci

Berti

et al. 1999

Anatomy and Embryology

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The perikaryal surface of spinal ganglion neurons undergoes dynamic changes throughout life. In particular, numerous slender projections develop and retract continuously from this surface. We showed previously that the outgrowth of these projections, while an intrinsic property of spinal ganglion neurons, is also influenced by the surrounding microenvironment. Since the latter consists of satellite cells and the extracellular matrix, we sought to determine the relative contributions of each of these components to the outgrowth of perikaryal projections. To this end, we took advantage of a little known characteristic of the satellite cell sheaths: in the rabbit, these sheaths can exhibit gaps that leave the nerve cell body surface directly exposed to the extracellular matrix. We compared the surface domains covered by satellite cells with those in direct contact with the extracellular matrix. We found that the perikaryal projections are abundant in the former domains but are absent in the latter. We also found that the perineuronal extracellular matrix of rabbit spinal ganglia contains laminin and fibronectin, two glycoproteins that have been reported to promote the growth of axonal processes from sensory ganglion neurons. Laminin and fibronectin were also present at the level of the gaps in the satellite cell sheath. These results: (1) provide additional evidence that environmental factors influence the outgrowth of perikaryal projections from spinal ganglion neurons; (2) suggest that satellite cells permit the outgrowth of these projections; (3) suggest that in the spinal ganglia of adult rabbits the perineuronal extracellular matrix is not in itself able to promote the outgrowth of these projections. This study provides a further example of the influence that supporting neuroglial cells have on sensory ganglion neurons.

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“…40 Importantly, when coexpressed in Xenopus oocytes, Na v 1.7 and b1 were found to functionally associate in a 1:1 ratio, with the resultant VGSC currents exhibiting more rapid inactivation, a small but significant (B5 mV) hyperpolarizing shift in steady-state activation and inactivation, and accelerated recovery from fast inactivation, compared to currents resulting from Na v 1.7 a-subunit expression alone. 41,42 In the present study, we found that Na v 1.7 mRNA levels were much lower than b1, even in strongly metastatic cells (Figure 2c).…”

Section: Vgsca and Vgscb Interactions In Cap Cellsmentioning

confidence: 98%

β-Subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression

Diss

Fraser

Walker

et al. 2007

Prostate Cancer Prostatic Dis

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We previously identified high levels of Na v 1.7 voltage-gated sodium channel a-subunit (VGSCa) mRNA and protein in human prostate cancer cells and tissues. Here, we investigated auxillary b-subunit (VGSCbs) expression. In vitro, the combined expression of all four VGSCbs was significantly (B4.5-fold) higher in strongly compared to weakly metastatic cells. This was mainly due to increased b1-expression, which was under androgenic control. In vivo, b1-b4 mRNAs were detectable and their expression in CaP vs non-CaP tissues generally reflected the in vitro levels in relation to metastatic potential. The possible role(s) of VGSCbs (VGSCa-associated and VGSCaindependent) in prostate cancer are discussed.

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Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro

Cited by 26 publications

References 71 publications

Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

The perikaryal surface of spinal ganglion neurons: differences between domains in contact with satellite cells and in contact with the extracellular matrix

β-Subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression

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Schwann cells modulate sodium channel expression in spinal sensory neurons in vitro

Cited by 26 publications

References 71 publications

Peripheral drive in A&alpha;/&beta;-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

Peripheral drive in A&alpha;/&beta;-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

The perikaryal surface of spinal ganglion neurons: differences between domains in contact with satellite cells and in contact with the extracellular matrix

β-Subunits of voltage-gated sodium channels in human prostate cancer: quantitative in vitro and in vivo analyses of mRNA expression

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Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation

Peripheral drive in Aα/β-fiber neurons is altered in a rat model of osteoarthritis: changes in following frequency and recovery from inactivation