Schwann cell precursors as a source for adrenal gland chromaffin cells

Lousado, Luiza; Prazeres, Pedro H. D. M.; Andreotti, Julia P.; Paiva, Ana; Azevedo, Patrick O.; Santos, Gabryella S P; Filev, Renato; Mintz, Akiva; Birbrair, Alexander

doi:10.1038/cddis.2017.456

Cited by 32 publications

(26 citation statements)

References 15 publications

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“…The hematopoietic stem cells, which give rise to all blood and immune cells throughout life, reside in a specific complex niche in the bone marrow, that supports the homeostasis of these cells, composed by osteoblasts, osteocytes, osteoclasts, endothelial cells, adipocytes, smooth muscle cells, pericytes, fibroblasts, macrophages, megakaryocytes, lymphocytes, hematopoietic progenitors, neutrophils, peripheral innervations, and Schwann cells [18,85,64,86–89,19,9,10,90,93]. Recent studies have revealed distinct contributions of several cellular components of the bone marrow to different functions of hematopoietic stem cells regulation.…”

Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecF-expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecF neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.

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Section: Perspectives / Future Directionsmentioning

confidence: 99%

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Azevedo

Paiva

Santos

et al. 2018

Cancer Metastasis Rev

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“…Genetically modified mice have been widely applied to study cell types within diverse tissues microenvironments (Borges and others 2017; Lousado and others in press). The ability to delete single genes in specific cell types in adult mice has allowed us to answer specific questions regarding the roles of different cell populations in the regulation of several physiologic and pathologic processes (Andreotti and others 2017).…”

Section: Targeting Pericytesmentioning

confidence: 99%

Pericytes Make Spinal Cord Breathless after Injury

et al. 2017

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Traumatic spinal cord injury is a devastating condition that leads to significant neurological deficits and reduced quality of life. Therapeutic interventions after spinal cord lesions are designed to address multiple aspects of the secondary damage. However, the lack of detailed knowledge about the cellular and molecular changes that occur after spinal cord injury restricts the design of effective treatments. Li and colleagues using a rat model of spinal cord injury and in vivo microscopy reveal that pericytes play a key role in the regulation of capillary tone and blood flow in the spinal cord below the site of the lesion. Strikingly, inhibition of specific proteins expressed by pericytes after spinal cord injury diminished hypoxia and improved motor function and locomotion of the injured rats. This work highlights a novel central cellular population that might be pharmacologically targeted in patients with spinal cord trauma. The emerging knowledge from this research may provide new approaches for the treatment of spinal cord injury.

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“…The subventricular zone is extensively vascularized by a rich plexus of blood vessels (Ihrie and Alvarez-Buylla, 2011). Vascular niches play important roles supporting stem cells in different organs (Kunisaki et al, 2013; Birbrairand Frenette, 2016; Khan et al, 2016; Asada et al, 2017; Borges et al, 2017; Lousado et al, 2017), including the brain (Goldberg and Hirschi, 2009). The vascular niches themselves are heterogeneous and contain distinct cell populations besides endothelial cells (Sena et al, 2017a,b), including vascular smooth muscle cells (Wanjare et al, 2013), perivascular microglia (Guillemin and Brew, 2004), perivascular adventitial cells (Crisan et al, 2012), perivascular fibroblasts (Soderblom et al, 2013), perivascular macrophages (Bechmann et al, 2001; Prazeres et al, 2017), and pericytes subpopulations (Almeida et al, 2017; Birbrair et al, 2017a,b, 2011, 2014a,b,c, 2013a,b,c,d, 2015; Birbrair and Delbono, 2015; Dias Moura Prazeres et al, 2017; Coatti et al, 2017; Santos et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Endothelial cells maintain neural stem cells quiescent in their niche

et al. 2017

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Niches are specialized microenvironments that regulate stem cells’ activity. The neural stem cell (NSC) niche defines a zone in which NSCs are retained and produce new cells of the nervous system throughout life. Understanding the signaling mechanisms by which the niche controls the NSC fate is crucial for the success of clinical applications. In a recent study, Sato and colleagues, by using state-of-the-art techniques, including sophisticated in vivo lineage-tracing technologies, provide evidence that endothelial amyloid precursor protein (APP) is an important component of the NSC niche. Strikingly, depletion of APP increased NSC proliferation in the subventricular zone, indicating that endothelial cells negatively regulate NSCs’ growth. The emerging knowledge from this research will be important for the treatment of several neurological diseases.

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Schwann cell precursors as a source for adrenal gland chromaffin cells

Cited by 32 publications

References 15 publications

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Pericytes Make Spinal Cord Breathless after Injury

Endothelial cells maintain neural stem cells quiescent in their niche

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